Výsledky vyhledávání - "Helen R Gosselt"

Akademický článek

Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients.

Autor: Helen R Gosselt, Costanza L Vallerga, Pooja R Mandaviya, Erik Lubberts, Johanna M W Hazes, Robert de Jonge, Sandra G Heil

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0247709 (2021)

AimTo identify differentially methylated positions (DMPs) and regions (DMRs) that predict response to Methotrexate (MTX) in early rheumatoid arthritis (RA) patients.Materials and methodsDNA from baseline peripheral blood mononuclear cells was extract

Externí odkaz: https://doaj.org/article/736434ab899447cabb519e42f9e12903

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Akademický článek

Natural language processing for automated triage and prioritization of individual case safety reports for case-by-case assessment

Autor: Thomas Lieber, Helen R. Gosselt, Pelle C. Kools, Okko C. Kruijssen, Stijn N. C. Van Lierop, Linda Härmark, Florence P. A. M. Van Hunsel

Publikováno v: Frontiers in Drug Safety and Regulation, Vol 3 (2023)

Objective: To improve a previously developed prediction model that could assist in the triage of individual case safety reports using the addition of features designed from free text fields using natural language processing.Methods: Structured featur

Externí odkaz: https://doaj.org/article/428dac1dba2b42fabada53a1599d3902

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Akademický článek

Global DNA (hydroxy)methylation is stable over time under several storage conditions and temperatures

Autor: Helen R. Gosselt, Pieter H. Griffioen, Bertrand D. van Zelst, Natanja Oosterom, Robert de Jonge, Sandra G. Heil

Publikováno v: Epigenetics, Vol 16, Iss 1, Pp 45-53 (2021)

Background: Epigenetic markers are often quantified and related to disease in stored samples. While, effects of storage on stability of these markers have not been thoroughly examined. In this longitudinal study, we investigated the influence of stor

Externí odkaz: https://doaj.org/article/ee25caab32914f6885619b8238933cdd

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Akademický článek

Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients

Autor: Helen R. Gosselt, Bertrand D. van Zelst, Maurits C. F. J. de Rotte, Johanna M. W. Hazes, Robert de Jonge, Sandra G. Heil

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-8 (2019)

Abstract Background Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has been shown to inhibit one-carbon metabolism, which is involved in the do

Externí odkaz: https://doaj.org/article/6e4f57ce5dbe4212b601f7ae281f2e2a

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Development of a multivariate prediction model to identify individual case safety reports which require clinical review

Autor: Helen R. Gosselt, Elizabeth A. Bazelmans, Thomas Lieber, Florence P. A. M. van Hunsel, Linda Härmark

Publikováno v: Pharmacoepidemiology and Drug Safety. 31:1300-1307

The number of Individual Case Safety Reports (ICSRs) in pharmacovigilance databases are rapidly increasing world-wide. The majority of ICSRs at the Netherlands Pharmacovigilance Centre Lareb is reviewed manually to identify potential signal triggerin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deeacd4ec5a51c1baa1dcdb5a1c1c9c5
https://doi.org/10.1002/pds.5553

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Sex differences in adverse drug reactions from Adalimumab and etanercept in patients with inflammatory rheumatic diseases

Autor: Helen R. Gosselt, Jette A. van Lint, Leanne J. Kosse, Phyllis I. Spuls, Harald E. Vonkeman, Sander W. Tas, Frank Hoentjen, Michael T. Nurmohamed, Bart J.F. van den Bemt, Martijn B.A. van Doorn, Naomi T. Jessurun

Publikováno v: Expert Opinion on Drug Safety. Taylor & Francis Ltd
Gosselt, H R, van Lint, J A, Kosse, L J, Spuls, P I, Vonkeman, H E, Tas, S W, Hoentjen, F, Nurmohamed, M T, van den Bemt, B J F, van Doorn, M B A & Jessurun, N T 2023, ' Sex differences in adverse drug reactions from Adalimumab and etanercept in patients with inflammatory rheumatic diseases ', Expert opinion on drug safety . https://doi.org/10.1080/14740338.2023.2181340
Expert opinion on drug safety. Taylor & Francis
Expert opinion on drug safety. Taylor and Francis Ltd.

Background: We examine sex differences in relation to the nature, frequency, and burden of patient-reported adverse drug reactions (ADRs) in patients with inflammatory rheumatic diseases. Research design and methods: Rheumatoid arthritis, psoriatic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc607e4de4e5ca6c882d4814677a707a
https://pure.eur.nl/en/publications/ded233d7-47b1-4304-88a5-3c9d87d47e17

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Complex machine-learning algorithms and multivariable logistic regression on par in the prediction of insufficient clinical response to methotrexate in rheumatoid arthritis

Autor: Paco M J Welsing, Helen R. Gosselt, Maja Bulatović-Ćalasan, Mark Hoogendoorn, Robert de Jonge, Floris P J G Lafeber, Maurits C. F. J. de Rotte, Maxime M A Verhoeven, Johanna M. W. Hazes

Publikováno v: Journal of Personalized Medicine, 11(1):44, 1-12. Multidisciplinary Digital Publishing Institute (MDPI)
Gosselt, H R, Verhoeven, M M A, Bulatović-ćalasan, M, Welsing, P M, de Rotte, M C F J, Hazes, J M W, Lafeber, F P J G, Hoogendoorn, M & de Jonge, R 2021, ' Complex machine-learning algorithms and multivariable logistic regression on par in the prediction of insufficient clinical response to methotrexate in rheumatoid arthritis ', Journal of personalized medicine, vol. 11, no. 1, 44, pp. 1-12 . https://doi.org/10.3390/jpm11010044
Journal of personalized medicine, 11(1):44, 1-12. MDPI
Journal of Personalized Medicine
Volume 11
Issue 1
Journal of personalized medicine, 11(1):44, 1-12. Multidisciplinary Digital Publishing Institute (MDPI)
Journal of Personalized Medicine, Vol 11, Iss 44, p 44 (2021)
Journal of Personalized Medicine, 11(1):44, 1-12. MDPI Multidisciplinary Digital Publishing Institute

The goals of this study were to examine whether machine-learning algorithms outperform multivariable logistic regression in the prediction of insufficient response to methotrexate (MTX)
secondly, to examine which features are essential for corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a523a1d505d8034cb1000c8d57076d
https://research.vu.nl/en/publications/b94a01e3-8bac-422b-9107-cbfc6c82d31c

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Disease-specific ADRs of TNF-α inhibitors as reported by patients with inflammatory rheumatic diseases: a registry-based prospective multicenter cohort study

Autor: Lieke H. Roest, Leanne J. Kosse, Jette A. van Lint, Helen R. Gosselt, Joep H.G. Scholl, Eugène van Puijenbroek, Harald E. Vonkeman, Sander W. Tas, Michael T. Nurmohamed, Bart J.F. van den Bemt, Naomi T. Jessurun

Publikováno v: Expert opinion on drug safety. Taylor and Francis Ltd.
Roest, L H, Kosse, L J, van Lint, J A, Gosselt, H R, Scholl, J H G, van Puijenbroek, E, Vonkeman, H E, Tas, S W, Nurmohamed, M T, van den Bemt, B J F & Jessurun, N T 2022, ' Disease-specific ADRs of TNF-α inhibitors as reported by patients with inflammatory rheumatic diseases : a registry-based prospective multicenter cohort study ', Expert opinion on drug safety . https://doi.org/10.1080/14740338.2022.2115479
Expert Opinion on Drug Safety, 22(3), 203-211. Taylor & Francis Ltd
Expert opinion on drug safety. Taylor & Francis
Expert Opinion on Drug Safety, 22, 203-211
Expert Opinion on Drug Safety, 22, 3, pp. 203-211

Contains fulltext : 291908.pdf (Publisher’s version ) (Open Access) BACKGROUND: The extent to which adverse drug reactions (ADRs) of biologics differ per immune-mediated inflammatory disease (IMID), and the relevance of tailoring ADR information pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ea8bbb8a3dc59e6d557cb6544db47f
https://pure.amc.nl/en/publications/diseasespecific-adrs-of-tnf-inhibitors-as-reported-by-patients-with-inflammatory-rheumatic-diseases(3d23586c-85c0-4881-aedb-7c1d0844bbec).html

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Analysis and visualization of the course and burden over time of adverse drug reactions (ADRs) attributed to TNFα-inhibitors in patients with inflammatory rheumatic diseases (IRDs)

Autor: Merel de Boer, Helen R Gosselt, Jurriaan Jansen, Martijn B.A van Doorn, Frank Hoentjen, Michael T Nurmohamed, Phyllis I Spuls, Sander W Tas, Harald E Vonkeman, Naomi T Jessurun

Publikováno v: Expert Opinion on Drug Safety, 22, 195-202
Expert Opinion on Drug Safety, 22, 3, pp. 195-202
Expert opinion on drug safety. Taylor and Francis Ltd.
Expert opinion on drug safety. Taylor & Francis
de Boer, M, Gosselt, H R, Jansen, J, van Doorn, M B A, Hoentjen, F, Nurmohamed, M T, Spuls, P I, Tas, S W, Vonkeman, H E & Jessurun, N T 2022, ' Analysis and visualization of the course and burden over time of adverse drug reactions (ADRs) attributed to TNFα-inhibitors in patients with inflammatory rheumatic diseases (IRDs) ', Expert opinion on drug safety . https://doi.org/10.1080/14740338.2022.2110237
Expert Opinion on Drug Safety, 22(3), 195-202. Taylor & Francis Ltd

Item does not contain fulltext BACKGROUND: We aimed to investigate course and burden over time of ADRs attributed to TNFα-inhibitors in IRD-patients, and whether Sankey diagrams and polar plots can visualize this. RESEARCH DESIGN AND METHODS: Data o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1526cb5a9b0e286fc5104b76b54fb240
http://www.scopus.com/inward/record.url?scp=85135775570&partnerID=8YFLogxK

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Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients

Autor: Sandra G. Heil, Johanna M. W. Hazes, Pooja R. Mandaviya, Helen R. Gosselt, Robert de Jonge, Erik Lubberts, Costanza L. Vallerga

Publikováno v: PLoS ONE, 16(3 March):e0247709. Public Library of Science
Gosselt, H R, Vallerga, C L, Mandaviya, P R, Lubberts, E, Hazes, J M W, De Jonge, R & Heil, S G 2021, ' Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients ', PLoS ONE, vol. 16, no. 3 March, e0247709 . https://doi.org/10.1371/journal.pone.0247709
PLoS ONE, Vol 16, Iss 3, p e0247709 (2021)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0fd5771f7ec16254edf2a37926dfa2
https://research.vumc.nl/en/publications/966060c0-9a90-40b2-bf84-253b8019ca74

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