Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Helen R, Morrin"'
Autor:
Rebekah L. I. Crake, Eleanor R. Burgess, George A. R. Wiggins, Nicholas J. Magon, Andrew B. Das, Margreet C. M. Vissers, Helen R. Morrin, Janice A. Royds, Tania L. Slatter, Bridget A. Robinson, Elisabeth Phillips, Gabi U. Dachs
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature. 5-hydroxymethylcytosine (5-hmC), an intermediate generated in the demethylation of 5-methylcytosine, is present at reduced le
Externí odkaz:
https://doaj.org/article/29bbf00353694620bd5b46e7983ef037
Autor:
Eleanor R. Burgess, Rebekah L. I. Crake, Elisabeth Phillips, Helen R. Morrin, Janice A. Royds, Tania L. Slatter, George A. R. Wiggins, Margreet C. M. Vissers, Bridget A. Robinson, Gabi U. Dachs
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma multiforme is a challenging disease with limited treatment options and poor survival. Glioblastoma tumours are characterised by hypoxia that activates the hypoxia inducible factor (HIF) pathway and controls a myriad of genes that drive c
Externí odkaz:
https://doaj.org/article/f59593b61a444e2e93b8171168297f54
Autor:
Elizabeth J. Campbell, Gabi U. Dachs, Helen R. Morrin, Valerie C. Davey, Bridget A. Robinson, Margreet C. M. Vissers
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is associated with HIF pathwa
Externí odkaz:
https://doaj.org/article/700ee1aa0e2a4759836ca19c6ee9503b
Autor:
Gabi U. Dachs, Jamish Gandhi, Christina Wohlrab, Anitra C. Carr, Helen R. Morrin, Juliet M. Pullar, Simone B. Bayer, Tim W. Eglinton, Bridget A. Robinson, Margreet C. M. Vissers
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
The use of high dose ascorbate infusions in cancer patients is widespread, but without evidence of efficacy. Several mechanisms whereby ascorbate could affect tumor progression have been proposed, including: (i) the localized generation of cytotoxic
Externí odkaz:
https://doaj.org/article/22e268b11b7e424287fd593dcc28be59
Autor:
Stephen B. Fox, Adrian L. Harris, Margaret C.P. Rees, Andrea Pellagatti, Helen R. Morrin, Sarah Gunningham, Daniele Generali, Helen Turley, Nischalan Pillay, Stephen Henderson, Russell Leek, Leonid L. Nikitenko
Purpose: The G-protein–coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers. We therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8ee3fccddd6e5cdc7413bd8dd0d3c0
https://doi.org/10.1158/1078-0432.c.6521351
https://doi.org/10.1158/1078-0432.c.6521351
Autor:
Stephen B. Fox, Adrian L. Harris, Margaret C.P. Rees, Andrea Pellagatti, Helen R. Morrin, Sarah Gunningham, Daniele Generali, Helen Turley, Nischalan Pillay, Stephen Henderson, Russell Leek, Leonid L. Nikitenko
PDF file, 840K, Supplementary Materials and Methods, Supplementary Figure Legends and Supplementary Figures Supplementary Figure S1. Transcriptional profile of ADM expression in paired patient-matched normal and carcinoma tissues. Supplementary Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715150d248bd33128a25c2629ff89a9e
https://doi.org/10.1158/1078-0432.22448267.v1
https://doi.org/10.1158/1078-0432.22448267.v1
Autor:
Eleanor R. Burgess, Rebekah L. I. Crake, Elisabeth Phillips, Helen R. Morrin, Janice A. Royds, Tania L. Slatter, George A. R. Wiggins, Margreet C. M. Vissers, Bridget A. Robinson, Gabi U. Dachs
Publikováno v:
Frontiers in oncology. 12
Glioblastoma multiforme is a challenging disease with limited treatment options and poor survival. Glioblastoma tumours are characterised by hypoxia that activates the hypoxia inducible factor (HIF) pathway and controls a myriad of genes that drive c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2740fcde56141666df5111e89574c20a
https://pubmed.ncbi.nlm.nih.gov/35419292
https://pubmed.ncbi.nlm.nih.gov/35419292
Autor:
Ramona A, Eiholzer, Sunali, Mehta, Marina, Kazantseva, Catherine J, Drummond, Cushla, McKinney, Katie, Young, David, Slater, Brianna C, Morten, Kelly A, Avery-Kiejda, Annette, Lasham, Nicholas, Fleming, Helen R, Morrin, Karen, Reader, Janice A, Royds, Michael, Landmann, Simone, Petrich, Roger, Reddel, Lily, Huschtscha, Ahmad, Taha, Noelyn A, Hung, Tania L, Slatter, Antony W, Braithwaite
Publikováno v:
Cancers
Simple Summary We investigated the influence of genetic variants, called single nucleotide polymorphisms (SNP) in the TP53 tumour suppressor gene, on cancer risk, clinical features and TP53 isoform levels. These SNPs were significantly over-represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d8e0160bb47b142578a878619fb7341
https://pubmed.ncbi.nlm.nih.gov/32882831
https://pubmed.ncbi.nlm.nih.gov/32882831
Autor:
Vickie Hanrahan, Margaret J Currie, Sarah P Gunningham, Helen R Morrin, Prudence AE Scott, Bridget A Robinson, Stephen B Fox
Publikováno v:
Journal of Pathology; Jun2003, Vol. 200 Issue 2, p183-194, 12p