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of 8
pro vyhledávání: '"Helen P. Matthews"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
When animal cells enter mitosis, they round up to become spherical. This shape change is accompanied by changes in mechanical properties. Multiple studies using different measurement methods have revealed that cell surface tension, intracellular pres
Externí odkaz:
https://doaj.org/article/3412bb269a844669ada58343f6cbd380
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Entry into mitosis triggers profound changes in cell shape and cytoskeletal organisation. Here, by studying microtubule remodelling in human flat mitotic cells, we identify a two-step process of interphase microtubule disassembly.
Externí odkaz:
https://doaj.org/article/32b5afbff8cf4d25b26d2cd5f2c5b0f4
Autor:
Marylin Desjardins, Swadhinya Arjunaraja, Jeffrey R. Stinson, Batsukh Dorjbal, Janani Sundaresan, Julie Niemela, Mark Raffeld, Helen F. Matthews, Angela Wang, Pamela Angelus, Helen C. Su, Bruce D. Mazer, Andrew L. Snow
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CARD11 is a lymphocyte-specific scaffold molecule required for proper activation of B- and T-cells in response to antigen. Germline gain-of-function (GOF) mutations in the CARD11 gene cause a unique B cell lymphoproliferative disorder known as B cell
Externí odkaz:
https://doaj.org/article/27da10c6f70a47b49f5c81ba79866af4
Autor:
Michelle Goldsworthy, Nathan L Absalom, David Schröter, Helen C Matthews, Debora Bogani, Lee Moir, Anna Long, Christopher Church, Alison Hugill, Quentin M Anstee, Rob Goldin, Mark Thursz, Florian Hollfelder, Roger D Cox
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e61870 (2013)
We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mous
Externí odkaz:
https://doaj.org/article/58b7322445b04143b65c00724e6e8374
Autor:
Robert Howard, Nicola Alder, Helen P. Matthews, Claire Merritt, Alastair Macdonald, Philip Wilkinson, Edmund Juszczak, Harriet Montgomery, Robin Jacoby
Publikováno v:
International Journal of Geriatric Psychiatry. 24:68-75
Objectives To standardise the delivery of a brief group cognitive behaviour therapy intervention (CBT-G). To apply the intervention in a research setting and to estimate its effect on recurrence rates in recently depressed older adults, in preparatio
Publikováno v:
British Journal of Psychiatry. 180:61-66
BackgroundThe Health of the Nation Outcomes Scales (HoNOS) have been developed to measure outcomes in people with mental health problems.AimsFrequent impaired social functioning, problems with communication and associated physical conditions meant th
Autor:
Helen P. Matthews, Lynne M. Drummond
Publikováno v:
The Journal of Nervous and Mental Disease. 176:688-691
A case history of obsessive-compulsive disorder occurring in a 32-year-old woman after benzodiazepine withdrawal is presented. The possible biochemical and neuropsychological mechanisms involved in the etiology and maintenance of this condition are r
Autor:
Helen P. Matthews, Lynne M. Drummond
Publikováno v:
British Journal of Psychiatry. 150:272-272