Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Helen P McWilliams-Koeppen"'
Autor:
Monichan Phay, Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Veronika Blinder, Tiernan T O'Malley, Alan Solomon, Dominic M Walsh, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137344 (2015)
Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findi
Externí odkaz:
https://doaj.org/article/d9c973e149054991ba50bef3823c4302
Autor:
Helen P McWilliams-Koeppen, James S Foster, Nicole Hackenbrack, Marina Ramirez-Alvarado, Dallas Donohoe, Angela Williams, Sallie Macy, Craig Wooliver, Dale Wortham, Jennifer Morrell-Falvey, Carmen M Foster, Stephen J Kennel, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137716 (2015)
Light chain (AL) amyloidosis is the most common form of systemic amyloid disease, and cardiomyopathy is a dire consequence, resulting in an extremely poor prognosis. AL is characterized by the production of monoclonal free light chains that deposit a
Externí odkaz:
https://doaj.org/article/7182f06f22c546f9ac3476127cafd2be
Autor:
Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A Farrell, Hartmut J Ehrlich, Hans P Schwarz, Dominic M Walsh, Alan Solomon, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50317 (2012)
Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer's disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precis
Externí odkaz:
https://doaj.org/article/b5e5d024a32647f4acc8c5e30db8eff6
Autor:
Zhiqiang Wang, Helen P. McWilliams-Koeppen, Hernan Reza, Julie R. Ostberg, Wuyang Chen, Xiuli Wang, Christian Huynh, Vibhuti Vyas, Wen-Chung Chang, Renate Starr, Jamie R. Wagner, Brenda Aguilar, Xin Yang, Xiwei Wu, Jinhui Wang, Wei Chen, Ellery Koelker-Wolfe, Christopher S. Seet, Amélie Montel-Hagen, Gay M. Crooks, Stephen J. Forman, Christine E. Brown
Publikováno v:
Cell Stem Cell. 29:651-653
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4c4342be08a9bc750e73d0b10af315
https://doi.org/10.1016/j.stem.2022.03.007
https://doi.org/10.1016/j.stem.2022.03.007
Autor:
Zhiqiang, Wang, Helen P, McWilliams-Koeppen, Hernan, Reza, Julie R, Ostberg, Wuyang, Chen, Xiuli, Wang, Christian, Huynh, Vibhuti, Vyas, Wen-Chung, Chang, Renate, Starr, Jamie R, Wagner, Brenda, Aguilar, Xin, Yang, Xiwei, Wu, Jinhui, Wang, Wei, Chen, Ellery, Koelker-Wolfe, Christopher S, Seet, Amélie, Montel-Hagen, Gay M, Crooks, Stephen J, Forman, Christine E, Brown
Publikováno v:
Cell stem cell. 29(4)
Unlimited generation of chimeric antigen receptor (CAR) T cells from human-induced pluripotent stem cells (iPSCs) is an attractive approach for "off-the-shelf" CAR T cell immunotherapy. Approaches to efficiently differentiate iPSCs into canonical α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f32d9cfc40a47a0208971a57b3fbbced
https://pubmed.ncbi.nlm.nih.gov/35395190
https://pubmed.ncbi.nlm.nih.gov/35395190
Autor:
Tatiana Perevozchikova, Erica Rowe, Helen P. McWilliams-Koeppen, Valerie Berthelier, Christopher B. Stanley
Publikováno v:
Biophysical Journal. 107:411-421
Acquiring detailed structural information about the various aggregation states of the huntingtin-exon1 protein (Htt-exon1) is crucial not only for identifying the true nature of the neurotoxic species responsible for Huntington’s disease (HD) but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94c2a0532f546ff8bffa3058363d781
https://doi.org/10.1016/j.bpj.2014.06.002
https://doi.org/10.1016/j.bpj.2014.06.002
Systemic peripheral amyloidosis is a rare disease in which misfolded proteins deposit in various organs. We have previously developed I-124 labeled peptide p5 + 14 as a tracer for positron emission tomography imaging of amyloid in patients. In this r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebf1f3cdc4dd46fdd20d3ccf3c4c592
https://europepmc.org/articles/PMC4874933/
https://europepmc.org/articles/PMC4874933/
Autor:
Hartmut J. Ehrlich, Luis Acero, Hans Peter Schwarz, Brian O'Nuallain, Alan Solomon, Angela Williams, Alfred L. Weber, Helen P. McWilliams-Koeppen
Publikováno v:
Journal of Clinical Immunology
Introduction We have previously shown that a subpopulation of naturally occurring human IgGs has therapeutic potential for the amyloid-associated disorders. These molecules cross-react with conformational epitopes on amyloidogenic assemblies, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab9e05fe740dbb4b9d62aaabd376c72
https://doi.org/10.1007/s10875-010-9413-6
https://doi.org/10.1007/s10875-010-9413-6
Autor:
Tiernan T. O'Malley, Brian O'Nuallain, Veronika Blinder, Helen P. McWilliams-Koeppen, Dominic M. Walsh, Monichan Phay, Angela Williams, Alan Solomon, Alfred T. Welzel
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137344 (2015)
PLoS ONE
PLoS ONE
Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d067687aad6c2989e54bd015bf6a829c
http://europepmc.org/articles/PMC4569075?pdf=render
http://europepmc.org/articles/PMC4569075?pdf=render
Autor:
Craig Wooliver, Carmen M. Foster, Helen P. McWilliams-Koeppen, Jonathan S. Wall, Nicole Hackenbrack, Dallas Donohoe, Marina Ramirez-Alvarado, Sallie Macy, Angela Williams, Stephen J. Kennel, Jennifer L. Morrell-Falvey, James S. Foster, Dale C. Wortham
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137716 (2015)
PLoS ONE
PLoS ONE
Light chain (AL) amyloidosis is the most common form of systemic amyloid disease, and cardiomyopathy is a dire consequence, resulting in an extremely poor prognosis. AL is characterized by the production of monoclonal free light chains that deposit a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6476f2a3dea172dcd4c10303618bec
http://europepmc.org/articles/PMC4579077?pdf=render
http://europepmc.org/articles/PMC4579077?pdf=render