Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Helen O, McCarthy"'
Autor:
Emma M. McErlean, Helen O. McCarthy
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-28 (2024)
Abstract Natural Killer (NK) cells are exciting candidates for cancer immunotherapy with potent innate cytotoxicity and distinct advantages over T cells for Chimeric Antigen Receptor (CAR) therapy. Concerns regarding the safety, cost, and scalability
Externí odkaz:
https://doaj.org/article/b2e42061d55e4d1e9ba4d72fcbae4d03
Autor:
Aaron R. J. Hutton, Melissa Kirkby, Tom Van Bogaert, Peter Casteels, Christelle Nonne, Veronique De Brabandere, Ortwin Van deVyver, Lalit K. Vora, Ismaiel A. Tekko, Helen O. McCarthy, Ryan F. Donnelly
Publikováno v:
Macromolecular Materials and Engineering, Vol 309, Iss 6, Pp n/a-n/a (2024)
Abstract Nanobody molecules, derived from heavy‐chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single‐domain format facilitates the constr
Externí odkaz:
https://doaj.org/article/ce0e799c4203426481c78b9c8f5d0d90
Autor:
Lalitkumar K. Vora, Ismaiel A. Tekko, Fabiana Volpe Zanutto, Akmal Sabri, Robert K. M. Choy, Jessica Mistilis, Priscilla Kwarteng, Maggie Kilbourne-Brook, Courtney Jarrahian, Helen O. McCarthy, Ryan F. Donnelly
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 946 (2024)
Microarray patches (MAPs) offer a noninvasive and patient-friendly drug delivery method, suitable for self-administration, which is especially promising for low- and middle-income country settings. This study focuses on the development of dissolving
Externí odkaz:
https://doaj.org/article/17497d416c8240b3a3209ce36d63fffb
Autor:
Yaocun Li, Lalitkumar K. Vora, Jiawen Wang, Akmal Hidayat Bin Sabri, Andrew Graham, Helen O. McCarthy, Ryan F. Donnelly
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 676 (2024)
Levodopa (LD) has been the most efficacious medication and the gold standard therapy for Parkinson’s disease (PD) for decades. However, its long-term administration is usually associated with motor complications, which are believed to be the result
Externí odkaz:
https://doaj.org/article/8ee96e7453f249b097b2bf2da17efa34
Autor:
Lalitkumar K. Vora, Ismaiel A. Tekko, Fabiana Volpe Zanutto, Akmal Sabri, Robert K. M. Choy, Jessica Mistilis, Priscilla Kwarteng, Courtney Jarrahian, Helen O. McCarthy, Ryan F. Donnelly
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 142 (2024)
Microarray patches (MAPs) have shown great potential for efficient and patient-friendly drug delivery through the skin; however, improving their delivery efficiency for long-acting drug release remains a significant challenge. This research provides
Externí odkaz:
https://doaj.org/article/39f92a0821aa4dac982bd51527feb4fb
Autor:
Chayanika Saha, James Bojdo, Nicholas J. Dunne, Raj Kumar Duary, Niamh Buckley, Helen O. McCarthy
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
High grade serous carcinoma (HGSC) is one of the most lethal ovarian cancers that is characterised by asymptomatic tumour growth, insufficient knowledge of malignant cell origin and sub-optimal detection. HGSC has been recently shown to originate in
Externí odkaz:
https://doaj.org/article/7eba80d1200641839c5344a4de45a8e7
Autor:
Lindsey A. Bennie, Jie Feng, Christopher Emmerson, Wendy B. Hyland, Kyle B. Matchett, Helen O. McCarthy, Jonathan A. Coulter
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Gold nanoparticles (AuNP) are effective radiosensitisers, however, successful clinical translation has been impeded by short systemic circulation times and poor internalisation efficiency. This work examines the potential of RALA,
Externí odkaz:
https://doaj.org/article/7e5641acdb7d44ffa88ca6b2e0d590dd
Autor:
Lynn N Jena, Lindsey A Bennie, Emma M McErlean, Sreekanth Pentlavalli, Kim Glass, James F Burrows, Vicky L Kett, Niamh E Buckley, Jonathan A Coulter, Nicholas J Dunne, Helen O McCarthy
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-BPs) have demonstrated direct ant
Externí odkaz:
https://doaj.org/article/ff00e18b61e540388dddf96e6bc47180
Autor:
Alejandro J. Paredes, Fabiana Volpe-Zanutto, Lalitkumar K. Vora, Ismaiel A. Tekko, Andi Dian Permana, Camila J. Picco, Helen O. McCarthy, Ryan F. Donnelly
Publikováno v:
Materials Today Bio, Vol 13, Iss , Pp 100217- (2022)
The human immunodeficiency virus (HIV) remains a global health concern, with 37.7 million people currently living with the infection and 1.5 million new cases every year. Current antiretroviral (ARV) therapies are administered through the oral route
Externí odkaz:
https://doaj.org/article/68ecb2db03dc433e8e430a83ae349cf9
Autor:
Nikoletta Sargioti, Tanya J. Levingstone, Eoin D. O’Cearbhaill, Helen O. McCarthy, Nicholas J. Dunne
Publikováno v:
Bioengineering, Vol 10, Iss 1, p 24 (2022)
Current procedures for transdermal drug delivery (TDD) have associated limitations including poor administration of nucleic acid, small or large drug molecules, pain and stress for needle phobic people. A painless micro-sized device capable of delive
Externí odkaz:
https://doaj.org/article/969bcee6050546c7a572bdffe4223ebf