Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults: an OpenSAFELY analysisResearch in context

Autor: Alasdair D. Henderson, Ben FC. Butler-Cole, John Tazare, Laurie A. Tomlinson, Michael Marks, Mark Jit, Andrew Briggs, Liang-Yu Lin, Oliver Carlile, Chris Bates, John Parry, Sebastian CJ. Bacon, Iain Dillingham, William A. Dennison, Ruth E. Costello, Yinghui Wei, Alex J. Walker, William Hulme, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Emily Herrett, Rosalind M. Eggo, Alex Walker, Amelia Green, Andrea Schaffer, Andrew Brown, Ben Butler-Cole, Caroline Morton, Caroline Walters, Catherine Stables, Christine Cunningham, Christopher Wood, Colm Andrews, David Evans, George Hickman, Helen Curtis, Henry Drysdale, Jessica Morley, Jon Massey, Linda Nab, Lisa Hopcroft, Louis Fisher, Lucy Bridges, Milan Wiedemann, Nicholas DeVito, Orla Macdonald, Peter Inglesby, Rebecca Smith, Richard Croker, Robin Park, Rose Higgins, Sebastian Bacon, Simon Davy, Steven Maude, Thomas O'Dwyer, Tom Ward, Victoria Speed, Liam Hart, Pete Stokes, Krishnan Bhaskaran, Ruth Costello, Thomas Cowling, Ian Douglas, Rosalind Eggo, Stephen Evans, Harriet Forbes, Richard Grieve, Daniel Grint, Sinead Langan, Viyaasan Mahalingasivam, Kathryn Mansfield, Rohini Mathur, Helen McDonald, Edward Parker, Christopher Rentsch, Anna Schultze, Liam Smeeth, Laurie Tomlinson, Jemma Walker, Elizabeth Williamson, Kevin Wing, Angel Wong, Bang Zheng, Christopher Bates, Jonathan Cockburn, Frank Hester, Sam Harper, Shaun O'Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths, Aaron Fowles, Nasreen Parkes, Rafael Perera, David Harrison, Kamlesh Khunti, Jonathan Sterne, Jennifer Quint

Publikováno v: EClinicalMedicine, Vol 72, Iss , Pp 102638- (2024)

Summary: Background: Long COVID is the patient-coined term for the persistent symptoms of COVID-19 illness for weeks, months or years following the acute infection. There is a large burden of long COVID globally from self-reported data, but the epide

Externí odkaz: https://doaj.org/article/44f9e56ee26a435d9956ffa4a1354eaa

A high-throughput pipeline for DNA/RNA/small RNA purification from tissue samples for sequencing

Autor: Jing Xu, Pawan K Pandoh, Richard D Corbett, Duane Smailus, Reanne Bowlby, Denise Brooks, Helen McDonald, Simon Haile, Sundeep Chahal, Steve Bilobram, Karen L Mungall, Andrew J Mungall, Robin Coope, Richard A Moore, Yongjun Zhao, Steven JM Jones, Marco A Marra

Publikováno v: BioTechniques, Vol 75, Iss 2, Pp 47-55 (2023)

High-throughput total nucleic acid (TNA) purification methods based on solid-phase reversible immobilization (SPRI) beads produce TNA suitable for both genomic and transcriptomic applications. Even so, small RNA species, including miRNA, bind weakly

Externí odkaz: https://doaj.org/article/320fbed6e6e54c1996d0d06202133dd1

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY

Autor: The OpenSAFELY Collaborative, Amelia Green, Helen Curtis, William Hulme, Elizabeth Williamson, Helen McDonald, Krishnan Bhaskaran, Christopher Rentsch, Anna Schultze, Brian MacKenna, Viyaasan Mahalingasivam, Laurie Tomlinson, Alex Walker, Louis Fisher, Jon Massey, Colm Andrews, Lisa Hopcroft, Caroline Morton, Richard Croker, Jessica Morley, Amir Mehrkar, Seb Bacon, David Evans, Peter Inglesby, George Hickman, Tom Ward, Simon Davy, Rohini Mathur, John Tazare, Rosalind Eggo, Kevin Wing, Angel Wong, Harriet Forbes, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Ian Douglas, Stephen Evans, Liam Smeeth, Ben Goldacre

Publikováno v: BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)

Abstract Background While the vaccines against COVID-19 are highly effective, COVID-19 vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants still circulating, describing the characteristics of individuals who have

Externí odkaz: https://doaj.org/article/5fb9fd19628a413e9a1d0e9303d74a1c

Guillain-Barré syndrome following SARS-CoV-2 vaccination in the UK: a prospective surveillance study

Autor: Peter M Fernandes, Louise Wiblin, Tom Solomon, Jonathan Evans, Benedict D Michael, Bart C Jacobs, Daniel Whittam, Harry Tucker, Emma Tallantyre, David P Breen, Neshika Samarasekera, Kathryn Knight, Martin Zeidler, Julia Stowe, Sonja E Leonhard, Victoria Harris, Helen McDonald, Kathryn Brennan, Eva Maria Hodel, Ralph Gregory, Katy Murray, Simon Shields, Andreas C Themistocleous, Stephen Sawcer, CLARE GALTON, Orla Tuohy, Stephan Hinze, Jacob Roelofs, James Holt, Julian Furby, Bhagteshwar Singh, Lucy Hogg, Scott Ramsay, Shue Jun Cheng, Andrew McHattie, Arina A Tamborska, Taylor Watson-Fargie, Caroline Morrice, Christopher M Allen, Gionathan Amante, Ana Carrilho Romeiro, Ginette Crossingham, Jon Evison, Alifa Isaacs-Itua, Mireia Moragas Garrido, Shelby Ramsamy, Pyae Phyo San, Robyn Terry

Publikováno v: BMJ Neurology Open, Vol 4, Iss 2 (2022)

Objective To investigate features of Guillain-Barré syndrome (GBS) following SARS-CoV-2 vaccines and evaluate for a causal link between the two.Methods We captured cases of GBS after SARS-CoV-2 vaccination through a national, open-access, online sur

Externí odkaz: https://doaj.org/article/520eb838f5a64a8a9e594d4a133f5181

Household tenure and its associations with multiple long-term conditions amongst working age adults: a cross-sectional analysis using linked primary care and local government records

Autor: Elizabeth Ingram, Manuel Gomes, Sue Hogarth, Helen McDonald, David Osborn, Jessica Sheringham

Publikováno v: International Journal of Population Data Science, Vol 7, Iss 2 (2022)

Background The increasing number of individuals living with multiple long-term conditions (MLTCs) is a huge public health challenge both globally and in the UK. MLTCs are more prevalent, have earlier onset, and are more likely to include mental healt

Externí odkaz: https://doaj.org/article/be413324c3414a11ac0c604d388c3806