Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Helen McIlleron"'
Autor:
Phiona E. Namale, Linda Boloko, Marcia Vermeulen, Kate A. Haigh, Fortuna Bagula, Alexis Maseko, Bianca Sossen, Scott Lee-Jones, Yoliswa Msomi, Helen McIlleron, Ayanda Trevor Mnguni, Thomas Crede, Patryk Szymanski, Jonathan Naude, Sakeena Ebrahim, Yakoob Vallie, Muhammed Shiraz Moosa, Ismail Bandeker, Shakeel Hoosain, Mark P. Nicol, Nazlee Samodien, Chad Centner, Wentzel Dowling, Paolo Denti, Freedom Gumedze, Francesca Little, Arifa Parker, Brendon Price, Denzil Schietekat, Bryony Simmons, Andrew Hill, Robert J. Wilkinson, Ida Oliphant, Siphokazi Hlungulu, Ivy Apolisi, Monica Toleni, Zimkhitha Asare, Mkanyiseli Kenneth Mpalali, Erica Boshoff, Denise Prinsloo, Francisco Lakay, Abulele Bekiswa, Amanda Jackson, Ashleigh Barnes, Ryan Johnson, Sean Wasserman, Gary Maartens, David Barr, Charlotte Schutz, Graeme Meintjes
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background HIV-associated tuberculosis (TB) contributes disproportionately to global tuberculosis mortality. Patients hospitalised at the time of the diagnosis of HIV-associated disseminated TB are typically severely ill and have a high mort
Externí odkaz:
https://doaj.org/article/407085ae244246269d749b344b833ee5
Autor:
Helen McIlleron, Lubbe Wiesner, Charlotte Schutz, Robert J. Wilkinson, Graeme Meintjes, Noha Abdelgawad, David Barr, Maxwell Chirehwa, Saskia Janssen, Amy Ward, Muki Shey, Rosie Burton, Gary Maartens, Paolo Denti
Publikováno v:
Wellcome Open Research, Vol 7 (2024)
Background Early mortality among hospitalized HIV-associated tuberculosis (TB/HIV) patients is high despite treatment. The pharmacokinetics of rifampicin, isoniazid, and pyrazinamide were investigated in hospitalized TB/HIV patients and a cohort of o
Externí odkaz:
https://doaj.org/article/9821005f3758442089e34947d7c6328b
Autor:
Lufina Tsirizani Galileya, Roeland E Wasmann, Chishala Chabala, Helena Rabie, Janice Lee, Irene Njahira Mukui, Anneke Hesseling, Heather Zar, Rob Aarnoutse, Anna Turkova, Diana Gibb, Mark F Cotton, Helen McIlleron, Paolo Denti
Publikováno v:
PLoS Medicine, Vol 20, Iss 11, p e1004303 (2023)
BackgroundThe current World Health Organization (WHO) pediatric tuberculosis dosing guidelines lead to suboptimal drug exposures. Identifying factors altering the exposure of these drugs in children is essential for dose optimization. Pediatric pharm
Externí odkaz:
https://doaj.org/article/aa73b4c4db55463fb38f8af390a8ffa2
Autor:
Roeland E. Wasmann, Tiziana Masini, Kerri Viney, Sabine Verkuijl, Annemieke Brands, Anneke C. Hesseling, Helen McIlleron, Paolo Denti, Kelly E. Dooley
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Following infection with Mycobacterium tuberculosis, young children are at high risk of developing severe forms of tuberculosis (TB) disease, including TB meningitis (TBM), which is associated with significant morbidity and mortality. In 2022, the Wo
Externí odkaz:
https://doaj.org/article/7d5f5eb528d14b1ea543e2e421c070cb
Autor:
Helen McIlleron, Lubbe Wiesner, Charlotte Schutz, Robert J. Wilkinson, Graeme Meintjes, Noha Abdelgawad, David Barr, Maxwell Chirehwa, Saskia Janssen, Amy Ward, Muki Shey, Rosie Burton, Gary Maartens, Paolo Denti
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background. Early mortality among hospitalized HIV-associated tuberculosis (TB/HIV) patients is high despite treatment. The pharmacokinetics of rifampicin, isoniazid, and pyrazinamide were investigated in hospitalized TB/HIV patients and a cohort of
Externí odkaz:
https://doaj.org/article/56113a50a2264986a7856b5529419cd9
Autor:
Nicholas D. Walter, Sarah E. M. Born, Gregory T. Robertson, Matthew Reichlen, Christian Dide-Agossou, Victoria A. Ektnitphong, Karen Rossmassler, Michelle E. Ramey, Allison A. Bauman, Victor Ozols, Shelby C. Bearrows, Gary Schoolnik, Gregory Dolganov, Benjamin Garcia, Emmanuel Musisi, William Worodria, Laurence Huang, J. Lucian Davis, Nhung V. Nguyen, Hung V. Nguyen, Anh T. V. Nguyen, Ha Phan, Carol Wilusz, Brendan K. Podell, N’ Dira Sanoussi, Bouke C. de Jong, Corinne S. Merle, Dissou Affolabi, Helen McIlleron, Maria Garcia-Cremades, Ekaterina Maidji, Franceen Eshun-Wilson, Brandon Aguilar-Rodriguez, Dhuvarakesh Karthikeyan, Khisimuzi Mdluli, Cathy Bansbach, Anne J. Lenaerts, Radojka M. Savic, Payam Nahid, Joshua J. Vásquez, Martin I. Voskuil
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
It is unclear why different antibiotics vary in their ability to shorten treatment of tuberculosis. Here, the authors show that a measure based on ribosomal RNA synthesis in Mycobacterium tuberculosis correlates with treatment shortening in culture,
Externí odkaz:
https://doaj.org/article/e0c6c2c659ca434dbad834a1759cfbb7
Autor:
Richard Court, Chad M. Centner, Maxwell Chirehwa, Lubbe Wiesner, Paolo Denti, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Helen McIlleron
Publikováno v:
International Journal of Infectious Diseases, Vol 105, Iss , Pp 688-694 (2021)
Background: Cycloserine, or its structural analogue terizidone, has been associated with neuropsychiatric toxicity (psychosis, depression, and neuropathy). Prospective clinical data on the incidence of and risk factors for neuropsychiatric toxicity i
Externí odkaz:
https://doaj.org/article/6ae1a1737cf54dba9bf642bea32b1e19
Autor:
Louvina E. van der Laan, Anthony J. Garcia-Prats, H. Simon Schaaf, Jana L. Winckler, Heather Draper, Jennifer Norman, Lubbe Wiesner, Helen McIlleron, Paolo Denti, Anneke C. Hesseling
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Given the high prevalence of multidrug-resistant (MDR)-TB in high HIV burden settings, it is important to identify potential drug-drug interactions between MDR-TB treatment and widely used nucleoside reverse transcriptase inhibitors (NRTIs) in HIV-po
Externí odkaz:
https://doaj.org/article/0efbb15ebb8e4f389d9763f01fa80e8a
Autor:
Bronwyn Myers, Tara C Bouton, Elizabeth J Ragan, Laura F White, Helen McIlleron, Danie Theron, Charles D H Parry, C Robert Horsburgh, Robin M Warren, Karen R Jacobson
Publikováno v:
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not clear. This study aims t
Externí odkaz:
https://doaj.org/article/1d9ed59181a842e4826231e98c04145e
Autor:
Chishala Chabala, Anna Turkova, Margaret J. Thomason, Eric Wobudeya, Syed Hissar, Vidya Mave, Marieke van der Zalm, Megan Palmer, Monica Kapasa, Perumal K. Bhavani, Sarath Balaji, Priyanka A. Raichur, Anne-Marie Demers, Graeme Hoddinott, Ellen Owen-Powell, Aarti Kinikar, Philippa Musoke, Veronica Mulenga, Rob Aarnoutse, Helen McIlleron, Anneke Hesseling, Angela M. Crook, Mark Cotton, Diana M. Gibb, on behalf of the SHINE trial team
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. Trials in adults with smear-ne
Externí odkaz:
https://doaj.org/article/c7b492728303475aa269ac5a2bc5f4ce