Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Helen M. Organ"'
Publikováno v:
Tetrahedron Letters. 35:1503-1506
An enantioselective total synthesis of nagilactone F is described. Functionalized tricyclic intermediate 3 was prepared using a high-yielding acetal-initiated/vinylsilane-terminated polyene cyclization of 5. Intramolecular alkoxy radical-mediated rem
Autor:
Francis J. Dumont, Judith M. Pisano, Mary Jo Staruch, Helen M. Organ, Peter J. Sinclair, Matthew J. Wyvratt, Mark A. Holmes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:657-662
A number of C21 derivatives of FK-506 were prepared and their immunosuppressant properties evaluated in a T-cell proliferation assay. Some of these compounds are surprisingly potent antagonists of FK-506-mediated immunosuppression.
Autor:
J. C. Menendez, David Díez-Martín, Nikesh R. Kotecha, Sergio Mantegani, Helen M. Organ, Bernard Joseph Banks, Steven V. Ley, Andrew D. White
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 25
An enantioselective total synthesis of nagilactone F is described. Functionalized tricyclic intermediate 3 was prepared using a high-yielding acetal-initiated/vinylsilane-terminated polyene cyclization of 5. Intramolecular alkoxy radical-mediated rem
Autor:
David Díez-Martín, Andrew D. White, J. Carlos Menéndez, Helen M. Organ, Steven V. Ley, Bernard Joseph Banks, Nikesh R. Kotecha, Sergio Mantegani
Publikováno v:
Tetrahedron. 48:7899-7938
The total synthesis of the spiroketal ionophore antibiotic routiennocin 1 (CP-61,405) employing π-allyltricarbonyl iron lactone complexes is described. These complexes were used as precursors for the preparation of substituted 2-phenylsulphonyl pyra
Publikováno v:
Tetrahedron. 41:3825-3836
Wittig and Horner-Wittig coupling reactions of tetrahydropyran or tetrahydrofuran 2-triphenylphosphonium salts or 2-diphenylphosphine oxides with aldehydes and lactols affords good yields of the corresponding enol ethers. In selected examples these e