Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Helen M. Cooper"'
Autor:
Belal Shohayeb, Kai Sempert, Tristan P. Wallis, Frédéric A. Meunier, Nela Durisic, Elizabeth A. O'Brien, Cecilia Flores, Helen M. Cooper
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110621- (2024)
Summary: Synaptic structural plasticity, the expansion of dendritic spines in response to synaptic stimulation, is essential for experience-dependent plasticity and is driven by branched actin polymerization. The WAVE regulatory complex (WRC) is conf
Externí odkaz:
https://doaj.org/article/a704eb31b95c4426b58aa8f4f74e4da0
Autor:
Kai Sempert, Belal Shohayeb, Vanessa Lanoue, Elizabeth A. O’Brien, Cecilia Flores, Helen M. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Structural plasticity, the ability of dendritic spines to change their volume in response to synaptic stimulation, is an essential determinant of synaptic strength and long-term potentiation (LTP), the proposed cellular substrate for learning and mem
Externí odkaz:
https://doaj.org/article/e2b3b46e3f444a3b8e5af93d1eda494f
Autor:
Danyon Harkins, Tracey J. Harvey, Cooper Atterton, Ingrid Miller, Laura Currey, Sabrina Oishi, Maria Kasherman, Raul Ayala Davila, Lucy Harris, Kathryn Green, Hannah Piper, Robert G. Parton, Stefan Thor, Helen M. Cooper, Michael Piper
Publikováno v:
Cells, Vol 11, Iss 15, p 2377 (2022)
Nuclear factor one X (NFIX) is a transcription factor required for normal ependymal development. Constitutive loss of Nfix in mice (Nfix−/−) is associated with hydrocephalus and sloughing of the dorsal ependyma within the lateral ventricles. Prev
Externí odkaz:
https://doaj.org/article/5e119d222a894d89991f619199713ad6
Autor:
Santiago Cuesta, Dominique Nouel, Lauren M. Reynolds, Alice Morgunova, Angélica Torres-Berrío, Amanda White, Giovanni Hernandez, Helen M. Cooper, Cecilia Flores
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The fine arrangement of neuronal connectivity during development involves the coordinated action of guidance cues and their receptors. In adolescence, the dopamine circuitry is still developing, with mesolimbic dopamine axons undergoing target-recogn
Externí odkaz:
https://doaj.org/article/12483ee72a724ed29e7cab0f3832c580
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the neocortex. The establishment of a highly apicobasally polarized r
Externí odkaz:
https://doaj.org/article/6081c1c100034838b7ba8009edfc15b6
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The unique dendritic architecture of a given neuronal subtype determines its synaptic connectivity and ability to integrate into functional neuronal networks. It is now clear that abnormal dendritic structure is associated with neuropsychiat
Externí odkaz:
https://doaj.org/article/a1859b9f6ea446528bbd49524c971c62
Autor:
Conor J. O’Leary, Cathrin C. Nourse, Natalie K. Lee, Amanda White, Michael Langford, Kai Sempert, Stacey J. Cole, Helen M. Cooper
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 370-383 (2017)
Denudation of the ependyma due to loss of cell adhesion mediated by cadherin-based adherens junctions is a common feature of perinatal hydrocephalus. Junctional stability depends on the interaction between cadherins and the actin cytoskeleton. Howeve
Externí odkaz:
https://doaj.org/article/ae259e67556642bfaa0b7681dc03e710
Autor:
Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation
Externí odkaz:
https://doaj.org/article/e78b4bf4b2f348dc937c00673a6a639b
Autor:
Laura Morcom, Ilan Gobius, Ashley PL Marsh, Rodrigo Suárez, Jonathan WC Lim, Caitlin Bridges, Yunan Ye, Laura R Fenlon, Yvrick Zagar, Amelia M Douglass, Amber-Lee S Donahoo, Thomas Fothergill, Samreen Shaikh, Peter Kozulin, Timothy J Edwards, Helen M Cooper, IRC5 Consortium, Elliott H Sherr, Alain Chédotal, Richard J Leventer, Paul J Lockhart, Linda J Richards
Publikováno v:
eLife, Vol 10 (2021)
The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC)
Externí odkaz:
https://doaj.org/article/4a4fe948486c4254923af27e13cc05a1
Autor:
Sally Martin, Daniel Poppe, Nelly Olova, Conor O’Leary, Elena Ivanova, Jahnvi Pflueger, Jennifer Dechka, Rebecca K. Simmons, Helen M. Cooper, Wolf Reik, Ryan Lister, Ernst J. Wolvetang
Publikováno v:
Genes; Volume 14; Issue 5; Pages: 957
DNA methylation in neurons is directly linked to neuronal genome regulation and maturation. Unlike other tissues, vertebrate neurons accumulate high levels of atypical DNA methylation in the CH sequence context (mCH) during early postnatal brain deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dce4b6c29ce6374c5ecc92c3580d09c