Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Helen M Troop"'
Publikováno v:
British Journal of Pharmacology. 138:1093-1100
The natural product willardiine is an AMPA receptor agonist. We have examined the structural changes required to convert willardiine into an antagonist at AMPA and kainate receptors. Structure–activity analysis has been carried out to discover the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc3e52d18cd30741bdb3e67800159506
https://doi.org/10.1038/sj.bjp.0705148
https://doi.org/10.1038/sj.bjp.0705148
Publikováno v:
British Journal of Pharmacology. 137:1125-1133
1. The natural product willardiine is a selective AMPA receptor agonist. We report that an N(3)-substituted analogue of willardiine, (S)-3-(4-carboxybenzyl)willardiine 3-CBW, antagonizes AMPA and kainate receptors expressed on motoneurones and dorsal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dc0ad8ea959ed16f72c7f2cb86d2dad
https://doi.org/10.1038/sj.bjp.0704957
https://doi.org/10.1038/sj.bjp.0704957
Autor:
Julia C. A. More, David E. Jane, Graham L. Collingridge, David Bleakman, Jody L. Knauss, Helen M Troop, Andrew Alt, Nigel P. Dolman
Publikováno v:
Journal of medicinal chemistry. 49(8)
N3-substitution of the uracil ring of willardiine with a variety of carboxyalkyl or carboxybenzyl substituents produces AMPA and kainate receptor antagonists. In an attempt to improve the potency and selectivity of these AMPA and kainate receptor ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4be89fe1089a0b7988e8bccaac13e48
https://pubmed.ncbi.nlm.nih.gov/16610801
https://pubmed.ncbi.nlm.nih.gov/16610801
Autor:
David Bleakman, Nigel P. Dolman, Samantha Jack, David E Jane, Richard M. Morley, Julia C. A. More, Andrew Alt, Zuner A. Bortolotto, Robert Nisticò, Peter J. Roberts, Helen M Troop, Jody L. Knauss, Graham L. Collingridge
Publikováno v:
Journal of medicinal chemistry. 48(24)
The natural product willardiine (8) is an AMPA receptor agonist while 5-iodowillardiine (10) is a selective kainate receptor agonist. In an attempt to produce antagonists of kainate and AMPA receptors analogues of willardiine with substituents at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251754fe7ba85f935de7c0d98faf024f
https://pubmed.ncbi.nlm.nih.gov/16302825
https://pubmed.ncbi.nlm.nih.gov/16302825
Autor:
Julia C. A. More, Ann Marie L. Ogden, David E. Jane, Vernon R. J. Clarke, Zuner A. Bortolotto, Nigel P. Dolman, Fabio Pilato, Robert Nisticò, Andrew Alt, David Bleakman, Floris P. Buelens, Graham L. Collingridge, Helen M Troop, Eve E. Kelland
Willardiine derivatives with an N3-benzyl substituent bearing an acidic group have been synthesized with the aim of producing selective antagonists for GLUK5-containing kainate receptors. UBP296 was found to be a potent and selective antagonist of na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3f707d8a6a5ef58f76157c818b83e0
http://hdl.handle.net/11573/514325
http://hdl.handle.net/11573/514325
Publikováno v:
British journal of pharmacology. 138(6)
1. The natural product willardiine is an AMPA receptor agonist. We have examined the structural changes required to convert willardiine into an antagonist at AMPA and kainate receptors. Structure-activity analysis has been carried out to discover the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3069ebf73bf5de037f3c0a38f5bbb9f
https://pubmed.ncbi.nlm.nih.gov/12684265
https://pubmed.ncbi.nlm.nih.gov/12684265
Autor:
Lynda M. Hawkins, Helen M Troop, N.K. Thomas, David E. Jane, Jacqueline C. Miller, Peter J. Roberts
Publikováno v:
Neuropharmacology. 37(10-11)
The objectives of this study, conducted on neonatal rat spinal cord and dorsal roots in vitro, were to characterise the actions of a range of willardiine analogues on GluR5-containing kainate receptors present in dorsal roots, to determine whether Gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b011b3542be65df5ce033c85d3667fe
https://pubmed.ncbi.nlm.nih.gov/9849660
https://pubmed.ncbi.nlm.nih.gov/9849660