Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Autor: Marc Daigneault, Thushan I De Silva, Martin A Bewley, Julie A Preston, Helen M Marriott, Andrea M Mitchell, Timothy J Mitchell, Robert C Read, Moira K B Whyte, David H Dockrell

Publikováno v: PLoS Pathogens, Vol 8, Iss 7, p e1002814 (2012)

Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incomplete

Externí odkaz: https://doaj.org/article/43f5810c5b064f1c963861ddb7bc27cf

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.

Autor: Marc Daigneault, Julie A Preston, Helen M Marriott, Moira K B Whyte, David H Dockrell

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8668 (2010)

Differentiated macrophages are the resident tissue phagocytes and sentinel cells of the innate immune response. The phenotype of mature tissue macrophages represents the composite of environmental and differentiation-dependent imprinting. Phorbol-12-

Externí odkaz: https://doaj.org/article/e382702111e94006b952a5f7159e0aaa

The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages

Autor: Kimberly D. Herman, Carl G. Wright, Helen M. Marriott, Sam C. McCaughran, Kieran A. Bowden, Mark O. Collins, Stephen A. Renshaw, Lynne R. Prince

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in inflamed tissues. Therapeutic induction of neutrophil apoptosis, a

Externí odkaz: https://doaj.org/article/3b6a66ae4ab6401e9ef5f5cc7bbfbef5

Pellino-1 Regulates the Responses of the Airway to Viral Infection

Autor: Mark E. Fife, Marnix R. Jonker, Elizabeth K. Marsh, Shao Cong Sun, Clare F. Muir, Lynne Williams, J. Kelley Bentley, Wim Timens, Ian Sabroe, Irene H. Heijink, Ben S. Barksby, Helen M. Marriott, James P. Stewart, Marc B. Hershenson, David H. Dockrell, Tracy Hussell, Amber R. Hart, Elizabeth C. Prestwich, Lee A. Borthwick, Lisa C. Parker

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology, 10:456. Frontiers Media SA

Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 ubiquitin ligase known to regulate virally-induced inflammation. We wished to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972dea53ebef5c744abf5dacd1b28327
https://doi.org/10.3389/fcimb.2020.00456

Evaluation of the anti-inflammatory effects of β-adrenoceptor agonists on human lung macrophages

Autor: Sharonjit K Gill, Helen M. Marriott, S. Kim Suvarna, Peter T. Peachell

Publikováno v: European Journal of Pharmacology. 793:49-55

The principal mechanism by which bronchodilator β-adrenoceptor agonists act is to relax airways smooth muscle although they may also be anti-inflammatory. However, the extent of anti-inflammatory activity and the cell types affected by these agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea533f870f2112dd265a18057f5f403
https://doi.org/10.1016/j.ejphar.2016.11.005