Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Helen M E Duyvesteyn"'
Autor:
Takayoshi Shirasaki, Hui Feng, Helen M E Duyvesteyn, William G Fusco, Kevin L McKnight, Ling Xie, Mark Boyce, Sathish Kumar, Rina Barouch-Bentov, Olga González-López, Ryan McNamara, Li Wang, Adriana Hertel-Wulff, Xian Chen, Shirit Einav, Joseph A Duncan, Maryna Kapustina, Elizabeth E Fry, David I Stuart, Stanley M Lemon
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010543 (2022)
Although picornaviruses are conventionally considered 'nonenveloped', members of multiple picornaviral genera are released nonlytically from infected cells in extracellular vesicles. The mechanisms underlying this process are poorly understood. Here,
Externí odkaz:
https://doaj.org/article/71fe0a3da16d43cda03ca15add33c19f
Autor:
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R. Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M. E. Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, E. Yvonne Jones
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The Wnt receptor Frizzled3 (FZD3) is important for brain axonal development and cancer progression. We report structures of FZD3 in complex with extracellular and intracellular binding nanobodies (Nb). The crystal structure of Nb8 in complex
Externí odkaz:
https://doaj.org/article/c600bbcc0576464685448dff366e8f2a
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection
Autor:
Chang Liu, Raksha Das, Aiste Dijokaite-Guraliuc, Daming Zhou, Alexander J. Mentzer, Piyada Supasa, Muneeswaran Selvaraj, Helen M. E. Duyvesteyn, Thomas G. Ritter, Nigel Temperton, Paul Klenerman, Susanna J. Dunachie, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-th
Externí odkaz:
https://doaj.org/article/cc28ab08066f4f34ade2b16555c78a91
Autor:
Daming Zhou, Piyada Supasa, Chang Liu, Aiste Dijokaite-Guraliuc, Helen M. E. Duyvesteyn, Muneeswaran Selvaraj, Alexander J. Mentzer, Raksha Das, Wanwisa Dejnirattisai, Nigel Temperton, Paul Klenerman, Susanna J. Dunachie, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for clinical use. Most potent antibodies bin
Externí odkaz:
https://doaj.org/article/40347f991a6543e8a3b3edb8d9a26a4b
Autor:
Courtney J. Mycroft-West, Sahar Abdelkarim, Helen M. E. Duyvesteyn, Neha S. Gandhi, Mark A. Skidmore, Raymond J. Owens, Liang Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix, which are involved in myriad structural and signaling processes. Mature HS polysaccharides contain complex, non-templated patterns of sulfation and epim
Externí odkaz:
https://doaj.org/article/8d75494486084852a741a389473a8453
Autor:
Tiong Kit Tan, Pramila Rijal, Rolle Rahikainen, Anthony H. Keeble, Lisa Schimanski, Saira Hussain, Ruth Harvey, Jack W. P. Hayes, Jane C. Edwards, Rebecca K. McLean, Veronica Martini, Miriam Pedrera, Nazia Thakur, Carina Conceicao, Isabelle Dietrich, Holly Shelton, Anna Ludi, Ginette Wilsden, Clare Browning, Adrian K. Zagrajek, Dagmara Bialy, Sushant Bhat, Phoebe Stevenson-Leggett, Philippa Hollinghurst, Matthew Tully, Katy Moffat, Chris Chiu, Ryan Waters, Ashley Gray, Mehreen Azhar, Valerie Mioulet, Joseph Newman, Amin S. Asfor, Alison Burman, Sylvia Crossley, John A. Hammond, Elma Tchilian, Bryan Charleston, Dalan Bailey, Tobias J. Tuthill, Simon P. Graham, Helen M. E. Duyvesteyn, Tomas Malinauskas, Jiandong Huo, Julia A. Tree, Karen R. Buttigieg, Raymond J. Owens, Miles W. Carroll, Rodney S. Daniels, John W. McCauley, David I. Stuart, Kuan-Ying A. Huang, Mark Howarth, Alain R. Townsend
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Vaccines for SARS-COV-2 are needed in the ongoing pandemic. Here the authors characterize a vaccine candidate that presents the receptor-binding domain (RBD) of SARS-CoV-2 spike protein on a synthetic VLP platform using SpyTag/SpyCatcher technology a
Externí odkaz:
https://doaj.org/article/6b95639b85804b348dfe9af334fe3bcf
Autor:
Daming Zhou, Ling Qin, Helen M. E. Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E. Fry, Jingshan Ren, Kuan-Ying A. Huang, David I. Stuart
Publikováno v:
Viruses, Vol 14, Iss 12, p 2625 (2022)
Echoviruses, for which there are currently no approved vaccines or drugs, are responsible for a range of human diseases, for example echovirus 11 (E11) is a major cause of serious neonatal morbidity and mortality. Decay-accelerating factor (DAF, also
Externí odkaz:
https://doaj.org/article/8ef0892035cc4e4ea0eb6467711beea1
Autor:
Tadeo Moreno-Chicano, Ali Ebrahim, Danny Axford, Martin V. Appleby, John H. Beale, Amanda K. Chaplin, Helen M. E. Duyvesteyn, Reza A. Ghiladi, Shigeki Owada, Darren A. Sherrell, Richard W. Strange, Hiroshi Sugimoto, Kensuke Tono, Jonathan A. R. Worrall, Robin L. Owen, Michael A. Hough
Publikováno v:
IUCrJ, Vol 6, Iss 6, Pp 1074-1085 (2019)
High-throughput X-ray crystal structures of protein–ligand complexes are critical to pharmaceutical drug development. However, cryocooling of crystals and X-ray radiation damage may distort the observed ligand binding. Serial femtosecond crystallog
Externí odkaz:
https://doaj.org/article/ad7f2d9a92a74ab3b6301d2289377fb5
Autor:
Ali Ebrahim, Tadeo Moreno-Chicano, Martin V. Appleby, Amanda K. Chaplin, John H. Beale, Darren A. Sherrell, Helen M. E. Duyvesteyn, Shigeki Owada, Kensuke Tono, Hiroshi Sugimoto, Richard W. Strange, Jonathan A. R. Worrall, Danny Axford, Robin L. Owen, Michael A. Hough
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 543-551 (2019)
An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein microcrystals using identical fixed-target supports at both synchrotrons and X-ray free-electron la
Externí odkaz:
https://doaj.org/article/d85919f46169431f8075520a1390d09b
Autor:
Tadeo Moreno-Chicano, Leiah M. Carey, Danny Axford, John H. Beale, R. Bruce Doak, Helen M. E. Duyvesteyn, Ali Ebrahim, Robert W. Henning, Diana C. F. Monteiro, Dean A. Myles, Shigeki Owada, Darren A. Sherrell, Megan L. Straw, Vukica Šrajer, Hiroshi Sugimoto, Kensuke Tono, Takehiko Tosha, Ivo Tews, Martin Trebbin, Richard W. Strange, Kevin L. Weiss, Jonathan A. R. Worrall, Flora Meilleur, Robin L. Owen, Reza A. Ghiladi, Michael A. Hough
Publikováno v:
IUCrJ. 9:610-624
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies. In the case of metalloenzymes that are h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87e861aab317069cf343756ad353b55
https://doi.org/10.1107/s2052252522006418
https://doi.org/10.1107/s2052252522006418