Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Helen M Byrne"'
Autor:
Rebecca M Johnson, Isaac J Stopard, Helen M Byrne, Philip M Armstrong, Douglas E Brackney, Ben Lambert
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1011975 (2024)
Arboviruses can emerge rapidly and cause explosive epidemics of severe disease. Some of the most epidemiologically important arboviruses, including dengue virus (DENV), Zika virus (ZIKV), Chikungunya (CHIKV) and yellow fever virus (YFV), are transmit
Externí odkaz:
https://doaj.org/article/0d77deb501c74aa99ffb1e5aba0840e5
Autor:
Jakub Köry, Vedang Narain, Bernadette J Stolz, Jakob Kaeppler, Bostjan Markelc, Ruth J Muschel, Philip K Maini, Joe M Pitt-Francis, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011252 (2024)
Tumour angiogenesis leads to the formation of blood vessels that are structurally and spatially heterogeneous. Poor blood perfusion, in conjunction with increased hypoxia and oxygen heterogeneity, impairs a tumour's response to radiotherapy. The opti
Externí odkaz:
https://doaj.org/article/bc036081c6b94ada82eb532b05c135a7
Autor:
Salvador Chulián, Bernadette J Stolz, Álvaro Martínez-Rubio, Cristina Blázquez Goñi, Juan F Rodríguez Gutiérrez, Teresa Caballero Velázquez, Águeda Molinos Quintana, Manuel Ramírez Orellana, Ana Castillo Robleda, José Luis Fuster Soler, Alfredo Minguela Puras, María V Martínez Sánchez, María Rosa, Víctor M Pérez-García, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011329 (2023)
Although children and adolescents with acute lymphoblastic leukaemia (ALL) have high survival rates, approximately 15-20% of patients relapse. Risk of relapse is routinely estimated at diagnosis by biological factors, including flow cytometry data. T
Externí odkaz:
https://doaj.org/article/98c5115ec1784f58bba7bc06fea347cf
Autor:
William Duncan Martinson, Rebecca McLennan, Jessica M Teddy, Mary C McKinney, Lance A Davidson, Ruth E Baker, Helen M Byrne, Paul M Kulesa, Philip K Maini
Publikováno v:
eLife, Vol 12 (2023)
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/2dc117d3186148a4bb07444cc33ce442
Autor:
Joshua A Bull, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010994 (2023)
We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial relationships between points marked with combinations of discrete and
Externí odkaz:
https://doaj.org/article/85faad1e1e0347b683f7db43435bee10
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009094 (2021)
Angiogenesis is the process by which blood vessels form from pre-existing vessels. It plays a key role in many biological processes, including embryonic development and wound healing, and contributes to many diseases including cancer and rheumatoid a
Externí odkaz:
https://doaj.org/article/24875cb0b6f143c9b9e5b1a630a64832
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008055 (2021)
We introduce a hybrid two-dimensional multiscale model of angiogenesis, the process by which endothelial cells (ECs) migrate from a pre-existing vascular bed in response to local environmental cues and cell-cell interactions, to create a new vascular
Externí odkaz:
https://doaj.org/article/6011e689154b41e69bf15c3473e11809
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1007961 (2020)
Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and response to treatment of different cancer cell lines. Their popularity is largely due to the reproducible manner in which spheroids grow: the diffusion of nutri
Externí odkaz:
https://doaj.org/article/99d7b95699f64d4489e431f58cdd5e9a
Autor:
Michael J Chen, Jonathan P Whiteley, Colin P Please, Franziska Ehlicke, Sarah L Waters, Helen M Byrne
Publikováno v:
Journal of Tissue Engineering, Vol 10 (2019)
A key step in the tissue engineering of articular cartilage is the chondrogenic differentiation of mesenchymal stem cells (MSCs) into chondrocytes (native cartilage cells). Chondrogenesis is regulated by transforming growth factor- β (TGF- β ), a s
Externí odkaz:
https://doaj.org/article/6c223b1bbe114660b51045dad77469b1
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006049 (2018)
The corneal micropocket angiogenesis assay is an experimental protocol for studying vessel network formation, or neovascularization, in vivo. The assay is attractive due to the ease with which the developing vessel network can be observed in the same
Externí odkaz:
https://doaj.org/article/7a94720943d44f388489afde2ee63191