Zobrazeno 1 - 10
of 404
pro vyhledávání: '"Helen M Byrne"'
Autor:
Praveen Weeratunga, Laura Denney, Joshua A. Bull, Emmanouela Repapi, Martin Sergeant, Rachel Etherington, Chaitanya Vuppussetty, Gareth D. H. Turner, Colin Clelland, Jeongmin Woo, Amy Cross, Fadi Issa, Carlos Eduardo de Andrea, Ignacio Melero Bermejo, David Sims, Simon McGowan, Yasemin-Xiomara Zurke, David J. Ahern, Eddie C. Gamez, Justin Whalley, Duncan Richards, Paul Klenerman, Claudia Monaco, Irina A. Udalova, Tao Dong, Agne Antanaviciute, Graham Ogg, Julian C. Knight, Helen M. Byrne, Stephen Taylor, Ling-Pei Ho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Single cell spatial interrogation of the immune-structural interactions in COVID −19 lungs is challenging, mainly because of the marked cellular infiltrate and architecturally distorted microstructure. To address this, we develop a suite o
Externí odkaz:
https://doaj.org/article/b67c218489ea4de7bab095865d7c0ef0
Autor:
Rebecca M Johnson, Isaac J Stopard, Helen M Byrne, Philip M Armstrong, Douglas E Brackney, Ben Lambert
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1011975 (2024)
Arboviruses can emerge rapidly and cause explosive epidemics of severe disease. Some of the most epidemiologically important arboviruses, including dengue virus (DENV), Zika virus (ZIKV), Chikungunya (CHIKV) and yellow fever virus (YFV), are transmit
Externí odkaz:
https://doaj.org/article/0d77deb501c74aa99ffb1e5aba0840e5
Autor:
Jakub Köry, Vedang Narain, Bernadette J Stolz, Jakob Kaeppler, Bostjan Markelc, Ruth J Muschel, Philip K Maini, Joe M Pitt-Francis, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011252 (2024)
Tumour angiogenesis leads to the formation of blood vessels that are structurally and spatially heterogeneous. Poor blood perfusion, in conjunction with increased hypoxia and oxygen heterogeneity, impairs a tumour's response to radiotherapy. The opti
Externí odkaz:
https://doaj.org/article/bc036081c6b94ada82eb532b05c135a7
Publikováno v:
Biological Imaging, Vol 4 (2024)
Imaging platforms for generating highly multiplexed histological images are being continually developed and improved. Significant improvements have also been made in the accuracy of methods for automated cell segmentation and classification. However,
Externí odkaz:
https://doaj.org/article/f9de153b25ec4024a816ba01e8a5871e
Autor:
Salvador Chulián, Bernadette J Stolz, Álvaro Martínez-Rubio, Cristina Blázquez Goñi, Juan F Rodríguez Gutiérrez, Teresa Caballero Velázquez, Águeda Molinos Quintana, Manuel Ramírez Orellana, Ana Castillo Robleda, José Luis Fuster Soler, Alfredo Minguela Puras, María V Martínez Sánchez, María Rosa, Víctor M Pérez-García, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011329 (2023)
Although children and adolescents with acute lymphoblastic leukaemia (ALL) have high survival rates, approximately 15-20% of patients relapse. Risk of relapse is routinely estimated at diagnosis by biological factors, including flow cytometry data. T
Externí odkaz:
https://doaj.org/article/98c5115ec1784f58bba7bc06fea347cf
Autor:
William Duncan Martinson, Rebecca McLennan, Jessica M Teddy, Mary C McKinney, Lance A Davidson, Ruth E Baker, Helen M Byrne, Paul M Kulesa, Philip K Maini
Publikováno v:
eLife, Vol 12 (2023)
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/2dc117d3186148a4bb07444cc33ce442
Autor:
Joshua A Bull, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010994 (2023)
We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial relationships between points marked with combinations of discrete and
Externí odkaz:
https://doaj.org/article/85faad1e1e0347b683f7db43435bee10
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-9 (2021)
Plain language summary The effectiveness of public health measures against COVID-19 has varied between countries, with some experiencing many infections and others containing transmission successfully. As vaccines are deployed, an important challenge
Externí odkaz:
https://doaj.org/article/82c2d936c4c448149de9bac518963f73
Autor:
Emma L. Brown, Thierry L. Lefebvre, Paul W. Sweeney, Bernadette J. Stolz, Janek Gröhl, Lina Hacker, Ziqiang Huang, Dominique-Laurent Couturier, Heather A. Harrington, Helen M. Byrne, Sarah E. Bohndiek
Publikováno v:
Photoacoustics, Vol 26, Iss , Pp 100357- (2022)
Mesoscopic photoacoustic imaging (PAI) enables non-invasive visualisation of tumour vasculature. The visual or semi-quantitative 2D measurements typically applied to mesoscopic PAI data fail to capture the 3D vessel network complexity and lack robust
Externí odkaz:
https://doaj.org/article/fc97a783ea6e487bbbfa8a3121ccf13c
Autor:
Marcin Paczkowski, Warren W. Kretzschmar, Bostjan Markelc, Stanley K. Liu, Leoni A. Kunz-Schughart, Adrian L. Harris, Mike Partridge, Helen M. Byrne, Pavitra Kannan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Using co-culture experiments and mathematical modelling, Paczkowski et al discover that prostate cancer spheroids comprising mixed tumour cell populations display enhanced growth and reduced radiation sensitivity due to competitive and antagonistic i
Externí odkaz:
https://doaj.org/article/a08140e263164d63ab72ee83c273ffdf