Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Helen M Blau"'
Autor:
Fabio Sarto, Martino V. Franchi, Jamie S. McPhee, Daniel W. Stashuk, Matteo Paganini, Elena Monti, Maira Rossi, Giuseppe Sirago, Sandra Zampieri, Evgeniia S. Motanova, Giacomo Valli, Tatiana Moro, Antonio Paoli, Roberto Bottinelli, Maria A. Pellegrino, Giuseppe De Vito, Helen M. Blau, Marco V. Narici
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1797-1810 (2024)
Abstract Background Degeneration of the motoneuron and neuromuscular junction (NMJ) and loss of motor units (MUs) contribute to age‐related muscle wasting and weakness associated with sarcopenia. However, these features have not been comprehensivel
Externí odkaz:
https://doaj.org/article/fd1d5ef2771c4359bc285ecaafe7b482
Autor:
Wing Tak Wong, Gianfranco Matrone, XiaoYu Tian, Simion Alin Tomoiaga, Kin Fai Au, Shu Meng, Sayumi Yamazoe, Daniel Sieveking, Kaifu Chen, David M Burns, James K Chen, Helen M Blau, John P Cooke
Publikováno v:
eLife, Vol 6 (2017)
We wish to identify determinants of endothelial lineage. Murine embryonic stem cells (mESC) were fused with human endothelial cells in stable, non-dividing, heterokaryons. Using RNA-seq, it is possible to discriminate between human and mouse transcri
Externí odkaz:
https://doaj.org/article/36d381251e1a49c49778a465e80177e3
Autor:
Gaspard Pardon, Alison S. Vander Roest, Orlando Chirikian, Foster Birnbaum, Henry Lewis, Erica A. Castillo, Robin Wilson, Aleksandra K. Denisin, Cheavar A. Blair, Colin Holbrook, Kassie Koleckar, Alex C. Y. Chang, Helen M. Blau, Beth L. Pruitt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) are powerful in vitro models to study the mechanisms underlying cardiomyopathies and cardiotoxicity. Quantification of the contractile function in single hiPSC-CMs
Externí odkaz:
https://doaj.org/article/1069e53e6dc340f895ccdf08770ab256
Autor:
Matteo Togninalli, Andrew T. V. Ho, Christopher M. Madl, Colin A. Holbrook, Yu Xin Wang, Klas E. G. Magnusson, Anna Kirillova, Andrew Chang, Helen M. Blau
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract The proper regulation of muscle stem cell (MuSC) fate by cues from the niche is essential for regeneration of skeletal muscle. How pro-regenerative niche factors control the dynamics of MuSC fate decisions remains unknown due to limitations
Externí odkaz:
https://doaj.org/article/06237dbc4b9c438c85677ca7e4a9b4bb
Autor:
Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with agi
Externí odkaz:
https://doaj.org/article/1cb547b9df374953936e2d5fd08f29bc
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that tamoxifen, a selective estrogen receptor modulator widely used to t
Externí odkaz:
https://doaj.org/article/bcc03fc6d7194bfeb4c491a1753444ab
Autor:
Elena Groppa, Paolo Martini, Nima Derakhshan, Marine Theret, Morten Ritso, Lin Wei Tung, Yu Xin Wang, Hesham Soliman, Mark Stephen Hamer, Laura Stankiewicz, Christine Eisner, Le Nevé Erwan, Chihkai Chang, Lin Yi, Jack H. Yuan, Sunny Kong, Curtis Weng, Josephine Adams, Lucas Chang, Anne Peng, Helen M. Blau, Chiara Romualdi, Fabio M.V. Rossi
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112051- (2023)
Summary: Efficient regeneration requires multiple cell types acting in coordination. To better understand the intercellular networks involved and how they change when regeneration fails, we profile the transcriptome of hematopoietic, stromal, myogeni
Externí odkaz:
https://doaj.org/article/c12b05e6be8a435eb48dd8d1046c9e9f
Autor:
Elisia D. Tichy, David K. Sidibe, Christopher D. Greer, Nicholas M. Oyster, Panteleimon Rompolas, Nadia A. Rosenthal, Helen M. Blau, Foteini Mourkioti
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Background Pax7 is a transcription factor involved in the specification and maintenance of muscle stem cells (MuSCs). Upon injury, MuSCs leave their quiescent state, downregulate Pax7 and differentiate, contributing to skeletal muscle regene
Externí odkaz:
https://doaj.org/article/27ec8e7c1d7b4772a6981532d288802e
Autor:
Srinath C. Sampath, Srihari C. Sampath, Andrew T. V. Ho, Stéphane Y. Corbel, Joshua D. Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M. Blau
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired m
Externí odkaz:
https://doaj.org/article/d4e2ae2b17c54b96800222a5fe7090a1
Autor:
Nora Yucel, Yu Xin Wang, Thach Mai, Ermelinda Porpiglia, Peder J. Lund, Glenn Markov, Benjamin A. Garcia, Sean C. Bendall, Michael Angelo, Helen M. Blau
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3939-3955.e6 (2019)
Summary: The impact of glucose metabolism on muscle regeneration remains unresolved. We identify glucose metabolism as a crucial driver of histone acetylation and myogenic cell fate. We use single-cell mass cytometry (CyTOF) and flow cytometry to cha
Externí odkaz:
https://doaj.org/article/a6a7fe8b0fb044af811f41a7b1931889