Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Helen M, Mcgettrick"'
Autor:
Georgiana Neag, Jonathan Lewis, Jason D. Turner, Julia E. Manning, Isaac Dean, Melissa Finlay, Gowsihan Poologasundarampillai, Jonathan Woods, Muhammad Arham Sahu, Kabir A. Khan, Jenefa Begum, Helen M. McGettrick, Ilaria Bellantuono, Victoria Heath, Simon W. Jones, Christopher D. Buckley, Roy Bicknell, Amy J. Naylor
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Type-H capillary endothelial cells control bone formation during embryogenesis and postnatal growth but few signalling mechanisms underpinning this influence have been characterised. Here, we identify a highly expressed type-H endothelial ce
Externí odkaz:
https://doaj.org/article/85498a388ee845cc9022af51c103ca92
Autor:
Oladimeji Abudu, Duy Nguyen, Isabel Millward, Julia E. Manning, Mussarat Wahid, Abbey Lightfoot, Francesca Marcon, Reena Merard, Sandra Margielewska-Davies, Keith Roberts, Rachel Brown, Sarah Powell-Brett, Samantha M. Nicol, Fouzia Zayou, Wayne D. Croft, Hayden Pearce, Paul Moss, Asif J. Iqbal, Helen M. McGettrick
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 172, Iss , Pp 116283- (2024)
Background: Galectins (Gal’s) are a family of carbohydrate-binding proteins that are known to support the tumour microenvironment through their immunosuppressive activity and ability to promote metastasis. As such they are attractive therapeutic ta
Externí odkaz:
https://doaj.org/article/c165695e9a5647bc8ea433d32b708818
Autor:
Saba Nayar, Elena Pontarini, Joana Campos, Onorina Berardicurti, Charlotte G. Smith, Saba Asam, David H. Gardner, Serena Colafrancesco, Davide Lucchesi, Rachel Coleby, Ming-May Chung, Valentina Iannizzotto, Kelly Hunter, Simon J. Bowman, Gianluca Carlesso, Ronald Herbst, Helen M. McGettrick, Jeff Browning, Christopher D. Buckley, Benjamin A. Fisher, Michele Bombardieri, Francesca Barone
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The study suggests a link between ICOS-ICOSL signaling and LTa3 induction on T cells. LTa3 subsequently activates fibroblasts in the salivary gland, leading to formation of tertiary lymphoid tissues (TLS).
Externí odkaz:
https://doaj.org/article/d98526377cb948829a419d58788242d6
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin resistance. Within the bone, osteoblasts and osteoclasts express the adiponectin receptors, however, there are conflicting rep
Externí odkaz:
https://doaj.org/article/470da4cf6d7540249dbdc633f9addf6b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/f5195fa840bd4ef197ef8f4f4fd97990
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Leukocyte recruitment to the site of injury is a crucial event in the regulation of an inflammatory response. Tight regulation of interactions between the endothelium and circulating leukocytes is necessary to ensure a protective response to injury d
Externí odkaz:
https://doaj.org/article/6f2666b534ee4e8abc96542457a22c04
Autor:
Laleh Pezhman, Sophie J Hopkin, Jenefa Begum, Silke Heising, Daniela Nasteska, Mussarat Wahid, G Ed Rainger, David J Hodson, Asif J Iqbal, Myriam Chimen, Helen M McGettrick
Publikováno v:
Clinical and Experimental Immunology. 212:1-10
Dysregulation of leukocyte trafficking, lipid metabolism, and other metabolic processes are the hallmarks that underpin and drive pathology in obesity. Current clinical management targets alternations in lifestyle choices (e.g. exercise, weight loss)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8b4a61c14481e7bff41cce35504a5e1
https://doi.org/10.1093/cei/uxad022
https://doi.org/10.1093/cei/uxad022
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The inappropriate accumulation and activation of leukocytes is a shared pathological feature of immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Cellular accumulation is therefore an attr
Externí odkaz:
https://doaj.org/article/a2b69bf51c4d4796bcbdcfc5e5f3b7e0
Autor:
Samuel R. Weaver, Bethany D. Skinner, Rhodri Furlong, Rebekah A. I. Lucas, N. Timothy Cable, Catarina Rendeiro, Helen M. McGettrick, Samuel J. E. Lucas
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/a32d9511c4d44974a39ba85dd2c6e7f7
Autor:
Samuel R. Weaver, Bethany D. Skinner, Rhodri Furlong, Rebekah A. I. Lucas, N. Timothy Cable, Catarina Rendeiro, Helen M. McGettrick, Samuel J. E. Lucas
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
This study examined acute cerebral hemodynamic and circulating neurotrophic factor responses to moderate intensity continuous exercise (MICT), guideline-based high intensity interval exercise (HIIT), and sprint interval exercise (SIT). We hypothesize
Externí odkaz:
https://doaj.org/article/b2aad74499ff4162a307b03a4314c5af