Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Helen L. Scott"'
1
Abnormal scaffold attachment factor 1 expression and localization in spinocerebellar ataxias and Huntington’s chorea
Autor: Andriana Gialeli, Nicola Buckner, Liang-Fong Wong, Kevin C Kemp, Caroline A Rivers, Nicholas D. Allen, Helen L. Scott, Alastair Wilkins, Gongyu Shi, James B. Uney, Oscar Cordero-Llana
Publikováno v: Buckner, N, Kemp, K C, Scott, H L, Shi, G, Rivers, C A, Gialeli, A, Wong, L-F, Cordero Llana, O, Allen, N, Wilkins, A & Uney, J B 2020, ' Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea ', Brain Pathology . https://doi.org/10.1111/bpa.12872
Brain Pathology
SAFB1 is a DNA and RNA binding protein that is highly expressed in the cerebellum and hippocampus and is involved in the processing of coding and non‐coding RNAs, splicing and dendritic function. We analyzed SAFB1 expression in the post‐mortem br
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d387dc2887fc0c2ce93f5d7fbe5b591
https://doi.org/10.1111/bpa.12872
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2
shRNA‐mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth
Autor: Kelly M Hares, Juliana Redondo, Andrew Herman, Helen L. Scott, Clare L Killick-Cole, Kevin C Kemp, Francesca Mills, Susan C Short, Risto A. Kauppinen, Gary Shaw, Alastair Wilkins, Lorena Sueiro Ballesteros, Heiko Wurdak, James B. Uney, Tom Batstone, Harry Bulstrode, William G B Singleton, Tim Brend, Kathreena M Kurian, Oscar Cordero-Llana, Harry R Haynes
Publikováno v: The Journal of Pathology
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201
The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcription fact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39bf5d26efe7fd0d11f188b4b54bded
http://europepmc.org/articles/PMC6462812
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4
MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex
Autor: Youn-Bok Lee, Joanna Howarth, Francesco Tamagnini, Zafar I. Bashir, E. C. Warburton, James B. Uney, Malcolm W. Brown, Helen L. Scott, Katherine E Narduzzo, Liang-Fong Wong
Publikováno v: The European Journal of Neuroscience
Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity in the perirhinal cortex. The CREB-responsive microRNA miR-132 has been shown to regulate synaptic transmission and w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b116808a3c34a351e2f0bf8cf391d4
http://europepmc.org/articles/PMC3488600
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5
Synaptic strength at the thalamocortical input to layer IV neonatal barrel cortex is regulated by protein kinase C
Autor: Neil Bannister, Stephanie Braud, John T.R. Isaac, Helen L. Scott
Publikováno v: Neuropharmacology. 52:185-192
Long-term synaptic plasticity is an important mechanism underlying the development of cortical circuits in a number of brain regions. In barrel cortex NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) play a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544490588dd9d3e5a21959b1b70f991f
https://doi.org/10.1016/j.neuropharm.2006.06.016
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6
MiR-132 Is Upregulated by Ischemic Preconditioning of Cultured Hippocampal Neurons and Protects them from Subsequent OGD Toxicity
Autor: Matthew P. Keasey, James B. Uney, Helen L. Scott, Stephen W. Kelly, Ioannis Bantounas
Publikováno v: Journal of molecular neuroscience : MN. 59(3)
We explored the response of a panel of selected microRNAs (miRNAs) in neuroprotection produced by ischemic preconditioning. Hippocampal neuronal cultures were exposed to a 30-min oxygen-glucose deprivation (OGD). In our hands, this duration of OGD do
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7252d62282aeb5e45a5c5a32502d0c3
https://pubmed.ncbi.nlm.nih.gov/27074745
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7
MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating
Autor: Youn-Bok Lee, Helen L. Scott, Leonidas A. Phylactou, Liang-Fong Wong, Paul Verkade, James B. Uney, Ioannis Bantounas, Joanna Howarth
Publikováno v: The Journal of Biological Chemistry
Background: “Mirrored” or complementary mammalian miRNAs have been predicted but none have yet been characterized. Results: miR-3120 and miR-214 are produced from the same intronic locus; miR-3120 regulates heat shock cognate protein 70 (Hsc70) a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c8e21450bc0400e34df9743ff33993
https://pubmed.ncbi.nlm.nih.gov/22393045
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8
Expression of long-term depression underlies visual recognition memory
Autor: Sarah Griffiths, James B. Uney, Helen L. Scott, Zafar I. Bashir, E. Clea Warburton, Malcolm W. Brown, Colin P. J. Glover, Alison S. Bienemann, Mohamed T. Ghorbel
Publikováno v: Neuron. 58(2)
SummaryThe modifications occurring in the brain during learning and memory are still poorly understood but may involve long-lasting changes in synaptic transmission (synaptic plasticity). In perirhinal cortex, a lasting decrement in neuronal responsi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd833a5558a6d93a222426128e1c5e7
https://pubmed.ncbi.nlm.nih.gov/18439398
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9
Developmental Synaptic Plasticity at the Thalamocortical Input to Barrel Cortex: Mechanisms and Roles
Autor: Michael I. Daw, John T.R. Isaac, Helen L. Scott
The thalamocortical (TC) input to layer IV provides the major pathway for ascending sensory information to the mammalian sensory cortex. During development there is a dramatic refinement of this input that underlies the maturation of the topographica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046f3fbc3a76e4dc25d14a025ea18769
https://europepmc.org/articles/PMC1952688/
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10
Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex
Autor: Jack R. Mellor, Neil Bannister, John W. Crabtree, Esra Gürdal, John T.R. Isaac, Tim A. Benke, Helen L. Scott
Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(21)
During the first week of life, there is a shift from kainate to AMPA receptor-mediated thalamocortical transmission in layer IV barrel cortex. However, the mechanisms underlying this change and the differential properties of AMPA and kainate receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e90f82d3093ce2047de2d3a9a1974d
https://pubmed.ncbi.nlm.nih.gov/15917466
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