Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Helen L. Reeve"'
Autor:
Irene González-Recio, Jorge Simón, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, Maria Mercado-Gómez, Rubén Rodríguez-Agudo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Carmen Fernández-Rodríguez, Donatello Castellana, Maria U. Latasa, Leticia Abecia, Juan Anguita, Teresa C. Delgado, Paula Iruzubieta, Javier Crespo, Serge Hardy, Petar D. Petrov, Ramiro Jover, Matías A. Avila, César Martín, Ute Schaeper, Michel L. Tremblay, James W. Dear, Steven Masson, Misti Vanette McCain, Helen L. Reeves, Raul J. Andrade, M. Isabel Lucena, Daniela Buccella, Luis Alfonso Martínez-Cruz, Maria L Martínez-Chantar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Drug induced liver injury (DILI) is an important cause acute liver failure. Here the authors report that serum Mg2+ serum levels decrease in patients with DILI as well as in preclinical animal models treated with acetaminophen overdose, and that earl
Externí odkaz:
https://doaj.org/article/2a4712610b65483485edb1bca7bf6fb0
Autor:
Helen L Reeve, Pier D. Lambiase, Jens Brock Johansen, Pedro Adragão, Francis Murgatroyd, Dominic A.M.J. Theuns, Susanne S. Pedersen, A Graham Stuart, Lucas V.A. Boersma
Publikováno v:
Pacing and Clinical Electrophysiology. 35:574-579
Background:Leads in and on the heart of the transvenous implantable cardioverter defibrillator (ICD) form the Achilles’ heel of this system due to potential for peri- and postimplant complications. The S-ICD is a newer generation of the ICD that do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d30e58123534f4c355211866bc1184f
https://doi.org/10.1111/j.1540-8159.2012.03337.x
https://doi.org/10.1111/j.1540-8159.2012.03337.x
Autor:
Brian E. Ford, Shruti S. Chachra, Katrina Rodgers, Tabassum Moonira, Ziad H. Al-Oanzi, Quentin M. Anstee, Helen L. Reeves, Jörn M. Schattenberg, Rebecca J. Fairclough, David M. Smith, Dina Tiniakos, Loranne Agius
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101722- (2023)
Objectives: The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables acute regulation of liver glucokinase to support metabolic demand. The common human GCKR rs1260326:Pro446 > Leu variant within a large linkage disequilibrium region associa
Externí odkaz:
https://doaj.org/article/bfd2b304f9c64daea275414d8bcedee8
Publikováno v:
Pilot and Feasibility Studies, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Background The number of incident cases and deaths from primary liver cancer, predominantly hepatocellular carcinoma (HCC), has increased markedly in the last two decades. HCC is generally diagnosed at an advanced stage, and most new cases a
Externí odkaz:
https://doaj.org/article/a292e29162104d6cb9bef8e5976b3420
Autor:
Hui Ye, Chaobo Chen, Hanghang Wu, Kang Zheng, Beatriz Martín-Adrados, Esther Caparros, Rubén Francés, Leonard J. Nelson, Manuel Gómez del Moral, Iris Asensio, Javier Vaquero, Rafael Bañares, Matías A. Ávila, Raúl J. Andrade, M. Isabel Lucena, Maria Luz Martínez-Chantar, Helen L. Reeves, Steven Masson, Richard S. Blumberg, Jordi Gracia-Sancho, Yulia A. Nevzorova, Eduardo Martínez-Naves, Francisco Javier Cubero
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Abstract Acetaminophen (APAP) hepatotoxicity induces endoplasmic reticulum (ER) stress which triggers the unfolded protein response (UPR) in hepatocytes. However, the mechanisms underlying ER stress remain poorly understood, thus reducing the options
Externí odkaz:
https://doaj.org/article/1cfd4329e56e47219aae65911f141a1f
Publikováno v:
Renal Denervation ISBN: 9781447152224
The ReCor Medical Paradise® Renal Denervation System delivers ultrasound energy to perform targeted circumferential denervation to the renal afferent and efferent sympathetic nerves with the goal of achieving a reduction in systemic arterial blood p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e60fc8b5ba00da12aaa93c223086888
https://doi.org/10.1007/978-1-4471-5223-1_9
https://doi.org/10.1007/978-1-4471-5223-1_9
Publikováno v:
The Journal of Physiology. 533:253-261
How the ductus arteriosus (DA) closes at birth remains unclear. Inhibition of O2-sensitive K+ channels may initiate the closure but the sensor mechanism is unknown. We hypothesized that changes in endogenous H2O2 could act as this sensor. Using chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a2298e0599efa88cd6679eef153935
https://doi.org/10.1111/j.1469-7793.2001.0253b.x
https://doi.org/10.1111/j.1469-7793.2001.0253b.x
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 279:L751-L757
To study developmental changes in intracellular calcium handling in pulmonary artery smooth muscle cells (PASMCs), cells were isolated from distal and proximal pulmonary arteries from rabbits at different developmental stages: juvenile (4–6 wk old)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1c6071333b27ebe076f416e3ffb223
https://doi.org/10.1152/ajplung.2000.279.4.l751
https://doi.org/10.1152/ajplung.2000.279.4.l751
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 277:L662-L666
The anorexic agent dexfenfluramine causes the development of primary pulmonary hypertension in susceptible patients by an unknown mechanism that may include changes in K+-channel activity and intracellular Ca2+concentration ([Ca2+]i). We investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee28dc7d739986865c0b721e052421c
https://doi.org/10.1152/ajplung.1999.277.3.l662
https://doi.org/10.1152/ajplung.1999.277.3.l662
Publikováno v:
Life Sciences. 65:1135-1140
G proteins are membrane-bound regulatory proteins which modulate the activity of ion channels and other effector systems. The GTP and GDP analogs GTP (γS) and GDP (βS) have been used to study the role of G proteins in numerous physiologic systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22afa6fcbc545b5d7878e9fce9cc8f25
https://doi.org/10.1016/s0024-3205(99)00347-1
https://doi.org/10.1016/s0024-3205(99)00347-1