Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Helen L. Kotze"'
Autor:
Piotr S. Gromski, Yun Xu, Helen L. Kotze, Elon Correa, David I. Ellis, Emily Grace Armitage, Michael L. Turner, Royston Goodacre
Publikováno v:
Metabolites, Vol 4, Iss 2, Pp 433-452 (2014)
Missing values are known to be problematic for the analysis of gas chromatography-mass spectrometry (GC-MS) metabolomics data. Typically these values cover about 10%–20% of all data and can originate from various backgrounds, including analytical,
Externí odkaz:
https://doaj.org/article/a656004fcb004106be7bd332e6a09189
Publikováno v:
Metabolomics. 9:535-544
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is potentially well placed to contribute to metabolomic analysis while bringing the added benefit of high resolution, label free imaging. The focused ion beams used to desorb species from the
Autor:
Warwick B. Dunn, Kaye J. Williams, Royston Goodacre, Helen L. Kotze, J. William Allwood, Emily G. Armitage
Publikováno v:
Armitage, E G, Kotze, H L, Allwood, J W, Dunn, W B, Goodacre, R & Williams, K 2015, ' Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells ', Scientific Reports, vol. 5, 15649, pp. 1-12 . https://doi.org/10.1038/srep15649
Armitage, E G, Kotze, H L, Allwood, J W, Dunn, W B, Goodacre, R & Williams, K 2015, ' Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells ' Scientific Reports, vol. 5, 15649, pp. 1-12 . https://doi.org/10.1038/srep15649
Scientific Reports
Armitage, E G, Kotze, H L, Allwood, J W, Dunn, W B, Goodacre, R & Williams, K 2015, ' Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells ' Scientific Reports, vol. 5, 15649, pp. 1-12 . https://doi.org/10.1038/srep15649
Scientific Reports
Hypoxia inducible factors (HIFs) plays an important role in oxygen compromised environments and therefore in tumour survival. In this research, metabolomics has been applied to study HIFs metabolic function in two cell models: mouse hepatocellular ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd94ec21768179252fd47996f0bd0711
https://eprints.gla.ac.uk/123020/1/123020.pdf
https://eprints.gla.ac.uk/123020/1/123020.pdf
Autor:
Nicholas P. Lockyer, John S. Fletcher, John C. Vickerman, Alex Henderson, Helen L. Kotze, Kaye J. Williams, Emily G. Armitage
Publikováno v:
Surface and Interface Analysis. 45:277-281
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is emerging as a tool for studying the metabolism of disease. ToF-SIMS enables chemical specificity in addition to high spatial resolution imaging of biological samples from cells to tissue. H
Autor:
Emily G. Armitage, Kaye J. Williams, John S. Fletcher, Helen L. Kotze, Nicholas P. Lockyer, John C. Vickerman, Alex Henderson
Publikováno v:
Surface and Interface Analysis. 45:282-285
It is known that hypoxia-inducible factor 1 (HIF-1) activity results in the coordinated up-regulation of a large number of proteins that facilitate cell survival in tumours; however, the effect of HIF-1 on cancer metabolism is less well characterised
With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer me
Publikováno v:
Correlation-based network analysis of cancer metabolism ISBN: 9781493906147
Metabolomics is a commonly used tool in systems biology. Since a range of metabolites can be detected in a single assay, metabolomics can be defined as a holistic and data-driven study of the low molecular weight metabolites present in biological sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c68f2fba61cf26fa57a0361ca64b6a87
https://doi.org/10.1007/978-1-4939-0615-4_3
https://doi.org/10.1007/978-1-4939-0615-4_3
Publikováno v:
Correlation-based network analysis of cancer metabolism ISBN: 9781493906147
The metabolome is considered the closest entity to the phenotype of a biological system. It displays the changes made at higher hierarchical levels such as the proteome, transcriptome and genome. For many diseases including cancer, studying the metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49039bd5b7669606316901d4e1d63490
https://doi.org/10.1007/978-1-4939-0615-4_1
https://doi.org/10.1007/978-1-4939-0615-4_1
Publikováno v:
Correlation-based network analysis of cancer metabolism ISBN: 9781493906147
Correlation analysis, first invented by Francis Galton and later scientifically conceptualised by Karl Pearson, has many powerful applications in biology for describing causality in biological systems. Ever since the 1920s, causation has been connect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1adb30aa12f6f538682c601207392fc
https://doi.org/10.1007/978-1-4939-0615-4_4
https://doi.org/10.1007/978-1-4939-0615-4_4
Publikováno v:
SpringerBriefs in Systems Biology ISBN: 9781493906147
Correlation-based network analysis of cancer metabolism
Correlation-based network analysis of cancer metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdac72104432adedc82e8011882d404a
https://doi.org/10.1007/978-1-4939-0615-4
https://doi.org/10.1007/978-1-4939-0615-4