Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by β-hydroxy-β-methylbutyrate

Autor: Michael J. Tisdale, Steven T. Russell, Helen L. Eley

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 295:E1409-E1416

beta-Hydroxy-beta-methylbutyrate (HMB; 50 microM) has been shown to attenuate the depression in protein synthesis in murine myotubes in response to lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha) with or without interferon-gamma (IF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c1d038a982cba72fb0a9187ff30887
https://doi.org/10.1152/ajpendo.90530.2008

Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition

Autor: Pria S. McDonald, Helen L. Eley, Michael J. Tisdale, Steven T. Russell

Publikováno v: Cancer Chemotherapy and Pharmacology. 63:651-659

Inhibition of dsRNA-activated protein kinase (PKR), not only attenuates muscle atrophy in a murine model of cancer cachexia (MAC16), but it also inhibits tumour growth. In vitro the PKR inhibitor maximally inhibited growth of MAC16 tumour cells at a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2227abd0948efd6699f330a1a6ddcfd2
https://doi.org/10.1007/s00280-008-0782-y

Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2α may signal skeletal muscle atrophy in weight-losing cancer patients

Autor: Michael J. Tisdale, Helen L. Eley, Richard J E Skipworth, K.C.H. Fearon, D A C Deans

Publikováno v: Eley, H L, Skipworth, R J E, Deans, D A C, Fearon, K C H & Tisdale, M J 2008, ' Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients ', British Journal of Cancer, vol. 98, no. 2, pp. 443-449 . https://doi.org/10.1038/sj.bjc.6604150
British Journal of Cancer

Previous studies suggest that the activation (autophosphorylation) of dsRNA-dependent protein kinase (PKR) can stimulate protein degradation, and depress protein synthesis in skeletal muscle through phosphorylation of the translation initiation facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1c5d40c18a8a93c13af230274a1be6
https://doi.org/10.1038/sj.bjc.6604150

Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II

Autor: Helen L. Eley, Michael J. Tisdale, Steven T. Russell

Publikováno v: Cellular Signalling. 19:1797-1806

The antioxidants butylated hydroxytoluene (BHT, 1 mM) and D-alpha-tocopherol (10 microM) completely attenuated protein degradation in murine myotubes in response to both proteolysis-inducing factor (PIF) and angiotensin II (Ang II), suggesting that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f95f7862ea26f738212733e9c29b36c
https://doi.org/10.1016/j.cellsig.2007.04.003

Attenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinase

Autor: Steven T. Russell, Helen L. Eley, Michael J. Tisdale

Publikováno v: British Journal of Cancer

Atrophy of skeletal muscle is due to a depression in protein synthesis and an increase in degradation. Studies in vitro have suggested that activation of the dsRNA-dependent protein kinase (PKR) may be responsible for these changes in protein synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ff91170ed404532a2abd5a8a48e816
https://doi.org/10.1038/sj.bjc.6603704