Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Helen L. Bullifent"'
Autor:
Nicola J. Senior, Kalesh Sasidharan, Richard J. Saint, Andrew E. Scott, Mitali Sarkar-Tyson, Philip M. Ireland, Helen L Bullifent, Z. Rong Yang, Karen Moore, Petra C. F. Oyston, Timothy P. Atkins, Helen S. Atkins, Orkun S. Soyer, Richard W. Titball
Publikováno v:
BMC Microbiology, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathogen a priority. Envi
Externí odkaz:
https://doaj.org/article/1ac8f1a3fcab47d2ad8d2ad511b68c40
Autor:
Nicola J. Walker, Elizabeth A. Clark, Donna C. Ford, Helen L. Bullifent, Erin V. McAlister, Melanie L. Duffield, K. Ravi Acharya, Petra C. F. Oyston
Publikováno v:
Open Biology, Vol 2, Iss 12 (2012)
The need for new antibiotics has become pressing in light of the emergence of antibiotic-resistant strains of human pathogens. Yersinia pestis, the causative agent of plague, is a public health threat and also an agent of concern in biodefence. It is
Externí odkaz:
https://doaj.org/article/e7bbae35ac114011b4e3646356157531
Autor:
Rachel E. Ireland, Richard W. Titball, Philip M. Ireland, Helen L. Bullifent, Nicola J. Senior, Zheng Rong Yang, Stephanie J. Southern, Andrew E. Scott, Michelle Nelson, Helen S. Atkins
Publikováno v:
Journal of Bacteriology
The intracellular bacterial pathogen Francisella tularensis causes a disease in humans characterized by the rapid onset of nonspecific symptoms such as swollen lymph glands, fever, and headaches. F. tularensis is one of the most infectious bacteria k
Autor:
Kalesh Sasidharan, Mitali Sarkar-Tyson, Andrew E. Scott, Orkun S. Soyer, Z. Rong Yang, Richard W. Titball, Helen S. Atkins, Helen L. Bullifent, Richard J. Saint, Nicola J. Senior, Timothy P. Atkins, Petra C. F. Oyston, Philip M. Ireland, Karen Moore
Publikováno v:
BMC Microbiology
BMC Microbiology, Vol 17, Iss 1, Pp 1-12 (2017)
BMC Microbiology, Vol 17, Iss 1, Pp 1-12 (2017)
Background The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathogen a priority. Environmental
Autor:
Richard J. Saint, Richard W. Titball, Konrad Paszkiewicz, Petra C. F. Oyston, Nicola J. Senior, Stephanie J. Southern, Karen Moore, Helen L. Bullifent, Mitali Sarkar-Tyson, Zheng Rong Yang, Olivia L. Champion, Timothy P. Atkins
Publikováno v:
Scientific Reports
Massively parallel sequencing technology coupled with saturation mutagenesis has provided new and global insights into gene functions and roles. At a simplistic level, the frequency of mutations within genes can indicate the degree of essentiality. H
Autor:
Angela M. Howells, Graeme Frith, Arcadio Garcı́a de Castro, Alan Tunnacliffe, Kam Dhaliwal, Richard W. Titball, Helen L. Bullifent, Kate F. Griffin
Publikováno v:
Research in Microbiology. 153:281-287
The otsA and otsB genes, encoding trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase respectively, have been isolated from Salmonella enterica serovar typhimurium and nucleotide-sequenced. Induction of trehalose biosynthesis by expo
Autor:
Helen C. Flick-Smith, E. Diane Williamson, Helen L. Bullifent, Paula Gibson, Richard W. Titball, Julie Miller, Sarah Hayward, Nicola J. Walker
Publikováno v:
Infection and Immunity. 70:1653-1656
The immunogenicity and protective efficacy of overlapping regions of the protective antigen (PA) polypeptide, cloned and expressed as glutathione S -transferase fusion proteins, have been assessed. Results show that protection can be attributed to in
Autor:
Marietta Flores-Díaz, Pramukh Jayasekeera, Dennis T. Crane, Alberto Alape-Girón, Helen L. Bullifent, Richard W. Titball, David S. Moss, Bryan Lingard, Marie Jepson
Publikováno v:
FEBS Letters. 495:172-177
Differences in the biological properties of the Clostridium perfringens phospholipase C (alpha-toxin) and the C. bifermentans phospholipase C (Cbp) have been attributed to differences in their carboxy-terminal domains. Three residues in the carboxy-t
Autor:
Paul T. Scott, Helen L. Bullifent, Anne Moir, Milena M. Awad, Julian I. Rood, Richard William Titball
Publikováno v:
Anaerobe. 2:365-371
The control of expression of the α-toxin gene (cpaorplc) ofClostridium perfringenshas been studied in three strains shown to have high (NCTC8237), intermediate (strain 13) and low (NCTC8533) phospholipase C activity in the culture supernatant. The p
Autor:
A. Ginter, F. Dessy, Helen L. Bullifent, Richard W. Titball, E. D. Williamson, P. Coppe, Angela M. Howells
Publikováno v:
Microbiology. 142:191-198
The α-toxin produced by the type strain of Clostridium perfringens (NCTC 8237) was shown to differ from the α-toxins produced by most strains of C. perfringens isolated from man and from calves with respect to reactivity with a neutralizing monoclo