Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Helen L Hellmich"'
Autor:
Harris A. Weisz, Deborah Kennedy, Steven Widen, Heidi Spratt, Stacy L. Sell, Christine Bailey, Melinda Sheffield-Moore, Douglas S. DeWitt, Donald S. Prough, Harvey Levin, Claudia Robertson, Helen L. Hellmich
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract High-throughput sequencing technologies could improve diagnosis and classification of TBI subgroups. Because recent studies showed that circulating microRNAs (miRNAs) may serve as noninvasive markers of TBI, we performed miRNA-seq to study T
Externí odkaz:
https://doaj.org/article/c734795419e6481684153ad2356800bb
Autor:
Harris A. Weisz, Deborah R. Boone, William S. Coggins, Gabrielle A. Edwards, Hannah E. Willey, Steven G. Widen, Dionicio Siegel, Andrew T. Nelson, Donald S. Prough, Helen L. Hellmich
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort. However, the present lack of effective treatment options for TBI, despite decades of research,
Externí odkaz:
https://doaj.org/article/db582d781c84428caddccf89f35d1893
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257965 (2021)
Many important questions remain regarding severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the viral pathogen responsible for COVID-19. These questions include the mechanisms explaining the high percentage of asymptomatic but highly infe
Externí odkaz:
https://doaj.org/article/8b4ec04386c941bd88ccab2052e186c1
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234185 (2020)
Early, ideally pre-symptomatic, recognition of common diseases (e.g., heart disease, cancer, diabetes, Alzheimer's disease) facilitates early treatment or lifestyle modifications, such as diet and exercise. Sensitive, specific identification of disea
Externí odkaz:
https://doaj.org/article/85797929f9244618b125b17893ca7d87
Autor:
Deborah R Boone, Harris A Weisz, Hannah E Willey, Karen E O Torres, Michael T Falduto, Mala Sinha, Heidi Spratt, Ian J Bolding, Kathea M Johnson, Margaret A Parsley, Douglas S DeWitt, Donald S Prough, Helen L Hellmich
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214741 (2019)
There are no existing treatments for the long-term degenerative effects of traumatic brain injury (TBI). This is due, in part, to our limited understanding of chronic TBI and uncertainty about which proposed mechanisms for long-term neurodegeneration
Externí odkaz:
https://doaj.org/article/58771cd8849649299f0f75126e5daede
Autor:
Stacy L Sell, Deborah R Boone, Harris A Weisz, Cesar Cardenas, Hannah E Willey, Ian J Bolding, Maria-Adelaide Micci, Michael T Falduto, Karen E O Torres, Douglas S DeWitt, Donald S Prough, Helen L Hellmich
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221163 (2019)
Patients with traumatic brain injury (TBI) are frequently diagnosed with depression. Together, these two leading causes of death and disability significantly contribute to the global burden of healthcare costs. However, there are no drug treatments f
Externí odkaz:
https://doaj.org/article/754433036c8a46c394dae95ae3d62754
Autor:
Deborah R Boone, Jeanna M Leek, Michael T Falduto, Karen E O Torres, Stacy L Sell, Margaret A Parsley, Jeremy C Cowart, Tatsuo Uchida, Maria-Adelaide Micci, Douglas S DeWitt, Donald S Prough, Helen L Hellmich
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185943 (2017)
Virally mediated RNA interference (RNAi) to knock down injury-induced genes could improve functional outcome after traumatic brain injury (TBI); however, little is known about the consequences of gene knockdown on downstream cell signaling pathways a
Externí odkaz:
https://doaj.org/article/dcba9c0c5c804dfea3605fef84eb3953
Autor:
Heidi Spratt, Stacy L. Sell, Harris A. Weisz, Melinda Sheffield-Moore, Helen L. Hellmich, Claudia S. Robertson, Harvey S. Levin, Deborah Kennedy, Douglas S. DeWitt, Donald S. Prough, Christine Bailey, Steven G. Widen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
High-throughput sequencing technologies could improve diagnosis and classification of TBI subgroups. Because recent studies showed that circulating microRNAs (miRNAs) may serve as noninvasive markers of TBI, we performed miRNA-seq to study TBI-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c1c3a8b89ea4a3ab2f29803194afb2
http://link.springer.com/article/10.1038/s41598-020-60133-z
http://link.springer.com/article/10.1038/s41598-020-60133-z
Autor:
Deborah R Boone, Maria-Adelaide Micci, Isabella G Taglialatela, Judy L Hellmich, Harris A Weisz, Min Bi, Donald S Prough, Douglas S DeWitt, Helen L Hellmich
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127287 (2015)
Cognitive deficits in survivors of traumatic brain injury (TBI) are associated with irreversible neurodegeneration in brain regions such as the hippocampus. Comparative gene expression analysis of dying and surviving neurons could provide insight int
Externí odkaz:
https://doaj.org/article/08d48c9dfd4b46daa32b5ebcc387be31
Autor:
Helen L Hellmich, Daniel R Rojo, Maria-Adelaide Micci, Stacy L Sell, Deborah R Boone, Jeanna M Crookshanks, Douglas S DeWitt, Brent E Masel, Donald S Prough
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53230 (2013)
Developing new pharmacotherapies for traumatic brain injury (TBI) requires elucidation of the neuroprotective mechanisms of many structurally and functionally diverse compounds. To test our hypothesis that diverse neuroprotective drugs similarly affe
Externí odkaz:
https://doaj.org/article/66bcdfc1856c4bea97c52b36c8696500