Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer

Autor: Nicolaus Friedrichs, Michael Kloth, Lukas C. Heukamp, Martin Peifer, Peter Propping, Ulrike Koitzsch, Markus Loeffler, Erika Mariotti, Alexandra Florin, Claudia Wodtke, Stefan Aretz, Sabine Merkelbach-Bruse, Christoph Engel, Reinhard Buettner, Katharina Koenig, Helen Kuenstlinger, Ursula Rommerscheidt-Fuss, Stefanie Holzapfel, Frank Ueckeroth, Thomas Zander, Vanessa Ruesseler, Margarete Odenthal

Publikováno v: Gut. 65:1296-1305

Objective Microsatellite instability (MSI) is detected in approximately 15% of all colorectal cancers (CRC) and virtually in all cases with Lynch syndrome. The MSI phenotype is caused by dysfunctional mismatch repair (MMR) and leads to accumulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f0fab61fa59b796ba6a932a1078522
https://doi.org/10.1136/gutjnl-2014-309026

A Genomics-Based Classification of Human Lung Tumors

Autor: Sabine Merkelbach-Bruse, Odd Terje Brustugun, Marius Lund-Iversen, Philipp A. Schnabel, Hans Hoffmann, Katharina Koenig, Kato Kambartel, Matthias Scheffler, Reinhard Buettner, Harry J.M. Groen, Jana Fassunke, C. Ligorio, Helen Kuenstlinger, Peter Nuemberg, Sylvie Lantuejoul, William Pao, Philippe Girard, Khosro Hekmat, Johannes Berg, Franziska Gabler, Winfried Randerath, Åslaug Helland, Joerg Saenger, Andreas Schlesinger, Elisabeth Brambilla, Lucia Nogova, Vito Michele Fazio, Monika Serke, Lucia Anna Muscarella, Ines Wilkening, Walburga Engel-Riedel, Sven Perner, Ilona Dahmen, Erich Stoelben, Steinar Solberg, Benjamin Solomon, Hans-Ulrich Schildhaus, Stefan Krueger, Lisa Meffert, Peter M. Schneider, Stefania Damiani, Elke Binot, Katja Schmitz, Toni-Maree Rogers, Ali-Nuri Huenerlituerkoglu, Ulrich Lang, Janine Altmueller, Hannie Sietsma, Chau Nguyen, Lynnette Fernandez-Cuesta, Pierre Validire, Federico Cappuzzo, Christian Mueller, Ulrich Gerigk, Gad Getz, Dirk Behringer, Christian Mattonet, Xin Lu, Wim Timens, Roman K. Thomas, Philippe Lorimier, Masyar Gardizi, Yuan Chen, William D. Travis, Thomas Zander, Prudence A. Russell, Danila Seidel, Marc Bos, Michaela Angelika Kleine, Egbert F. Smit, Matthias Heldwein, Corinna Ludwig, Russell Hyde, Scott L. Carter, Peter J.F. Snijders, Kerstin Albus, Roland Schnell, Alex Soltermann, Michael Hallek, Wolfgang Galetke, Eray Goekkurt, Benjamin Besse, Frauke Leenders, John K. Field, Matthew D. Wilkerson, Roopika Menon, Markus Litt-Lampe, Silvia Querings, Konrad Frank, Yon-Dschun Ko, Holger Moch, Denis Moro-Sibilot, Zoe Wainer, Erik Thunnissen, Lukas C. Heukamp, Walter Weder, Danille A. M. Heideman, Stephan Schmitz, Karin Toepelt, Rainer Kappes, Juergen Wolf, Ingelore Boessmann, Gavin M. Wright, Rainer Fricke, Thomas Muley, Martin L. Sos, Joachim H. Clement, Wolfgang Schulte, Christian Brambilla, Sascha Ansén, Viktor Achter, Jean-Charles Soria, D. Neil Hayes, Martin Peifer, Marcel Reiser, Magdalena Bogus

Publikováno v: Seidel, D, Zander, T, Heukamp, L C, Peifer, M, Bos, M, Fernandez-Cuesta, L, Leenders, F, Lu, X, Ansen, S, Gardizi, M, Nguyen, C, Berg, J, Russell, P, Wainer, Z, Schildhaus, H U, Rogers, T M, Solomon, B, Pao, W, Carter, S L, Getz, G, Hayes, D N, Wilkerson, M D, Thunnissen, E, Travis, W D, Perner, S, Wright, G, Brambilla, E, Buttner, R, Wolf, J, Gabler, F, Wilkening, I, Muller, C, Dahmen, I, Menon, R, Konig, K, Albus, K, Merkelbach-Bruse, S, Fassunke, J, Schmitz, K, Kuenstlinger, H, Kleine, M A, Binot, E, Querings, S, Altmuller, J, Bossmann, I, Numberg, P, Schneider, P M, Bogus, M, Soltermann, A, Moch, H, Brustugun, O T, Solberg, S, Lund-Iversen, M, Helland, A, Muley, T, Hoffmann, H, Schnabel, P A, Chen, Y, Groen, H, Timens, W, Sietsma, H, Clement, J H, Weder, W, Sanger, J, Stoelben, E, Ludwig, C, Engel-Riedel, W, Smit, E F, Heideman, D A M, Snijders, P J F, Nogova, L, Sos, M L, Mattonet, C, Topelt, K, Scheffler, M, Goekkurt, E, Kappes, R, Kruger, S, Kambartel, K, Behringer, D, Schulte, W, Galetke, W, Randerath, W, Heldwein, M, Schlesinger, A, Serke, M, Hekmat, K, Frank, K F, Schnell, R, Reiser, M, Hunerliturkoglu, A N, Schmitz, S, Meffert, L, Ko, Y D, Litt-Lampe, M, Gerigk, U, Fricke, R, Besse, B, Brambilla, C, Lantuejoul, S, Lorimier, P, Moro-Sibilot, D, Cappuzzo, F, Ligorio, C, Damiani, S, Field, J K, Hyde, R, Validire, P, Girard, P, Muscarella, L A, Fazio, V M, Hallek, M, Soria, J C, Achter, V, Lang, U & Thomas, R K 2013, ' A Genomics-Based Classification of Human Lung Tumors ', Science Translational Medicine, vol. 5, no. 209, pp. 209ra153 . https://doi.org/10.1126/scitranslmed.3006802
Science Translational Medicine; Vol 5
Science Translational Medicine, 5(209). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 5(209). American Association for the Advancement of Science

We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66843d0f2a6ec2231d73d891ddfa7d52
https://doi.org/10.1126/scitranslmed.3006802