Výsledky vyhledávání - "Helen Kenyon-Edwards"

Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR)

Autor: Francesca Perrucio, M. Abid Masood, Graham Smith, Charles E. Mowbray, M. J. Gardner, Helen Kenyon-Edwards, Charlotte Alice Louise Lane, Rhys M. Jones, Andrew Simon Bell, Wai L. Liu, Andrew C. Mansfield, Matthew D. Selby, Nick Clarke, Christopher D. Brown, Rachel Osborne

Publikováno v: Bioorganicmedicinal chemistry letters. 21(21)

We describe the identification of a potent, selective lead series that shows antagonism against the human histamine H4 receptor from thirteen actives identified in an HTS as part of a hit to lead program. By focusing on ligand efficiency and concurre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cff37a8b9aecdb9ca526367a990fe6
https://pubmed.ncbi.nlm.nih.gov/21955944

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