Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Helen K, Matthews"'
Publikováno v:
Trends in Cell Biology. 33:60-69
Mutations in RAS are key oncogenic drivers and therapeutic targets. Oncogenic Ras proteins activate a network of downstream signalling pathways, including extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K), promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619145a6ca60421bb5473edf60924d16
https://doi.org/10.1016/j.tcb.2022.09.002
https://doi.org/10.1016/j.tcb.2022.09.002
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
When animal cells enter mitosis, they round up to become spherical. This shape change is accompanied by changes in mechanical properties. Multiple studies using different measurement methods have revealed that cell surface tension, intracellular pres
Externí odkaz:
https://doaj.org/article/3412bb269a844669ada58343f6cbd380
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Entry into mitosis triggers profound changes in cell shape and cytoskeletal organisation. Here, by studying microtubule remodelling in human flat mitotic cells, we identify a two-step process of interphase microtubule disassembly.
Externí odkaz:
https://doaj.org/article/32b5afbff8cf4d25b26d2cd5f2c5b0f4
Oncogenic Ras has been shown to change the way cancer cells divide by increasing the forces generated during mitotic rounding. In this way, RasV12enables cancer cells to divide across a wider range of mechanical environments than normal cells. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7b9ca0367bbade49ed4482bbbcce015
https://doi.org/10.1101/2023.01.12.523730
https://doi.org/10.1101/2023.01.12.523730
Publikováno v:
Nature Reviews Molecular Cell Biology. 23:74-88
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a3e79bf43a142415a13dee3328ce50f
https://doi.org/10.1038/s41580-021-00404-3
https://doi.org/10.1038/s41580-021-00404-3
Autor:
Helen K. Matthews, Sushila Ganguli
Publikováno v:
Current Biology. 31:R957-R959
The role of altered tissue mechanics in early cancer development is not well understood. A new study reveals how oncogene activation generates force within a tissue to impact cell division in surrounding normal cells, which then contribute to tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6a2ef225498e97f88b96c8da9fb014
https://doi.org/10.1016/j.cub.2021.06.041
https://doi.org/10.1016/j.cub.2021.06.041
Autor:
Agata, Nyga, Jose J, Muñoz, Suze, Dercksen, Giulia, Fornabaio, Marina, Uroz, Xavier, Trepat, Buzz, Baum, Helen K, Matthews, Vito, Conte
Publikováno v:
Science Advances
Description
Uniform RAS activation in an epithelium induces a 2D-to-3D transformation through induction of mechanical instability.
The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor deve
Uniform RAS activation in an epithelium induces a 2D-to-3D transformation through induction of mechanical instability.
The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e113529018f7bb9e7e094c906ba00b86
https://pubmed.ncbi.nlm.nih.gov/34644109
https://pubmed.ncbi.nlm.nih.gov/34644109
Autor:
Soichiro Yamada, Marjolein J. Vliem, Jooske L Monster, Joleen S Cheah, Martijn Gloerich, Johan de Rooij, Helen K. Matthews, Buzz Baum, Zaw Win, Lisa Donker
Publikováno v:
The Journal of cell biology, vol 220, iss 5
The Journal of Cell Biology
Journal of Cell Biology
The Journal of Cell Biology
Journal of Cell Biology
Monster, Donker, et al. demonstrate how epithelial cells can round up as they enter mitosis while still maintaining the integrity of the epithelial barrier. This requires an asymmetric composition of mitotic cell–cell junctions, which is establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dda52f977a4fce151f9a2c06e69b00a
https://escholarship.org/uc/item/4xk6b3sh
https://escholarship.org/uc/item/4xk6b3sh
Autor:
Xavier Trepat, Helen K. Matthews, Giulia Fornabaio, Vito Conte, Suze Dercksen, Agata Nyga, Buzz Baum, José J. Muñoz, Marina Uroz
The RAS proto-oncogene is a critical regulator of cell state, morphology and mechanics, and plays a key role in cancer progression. Here, by using a human epithelial model in vitro, we ask how morpho-mechanical changes driven by oncogenic RAS activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea6adf72d14fecb602e15501352e87be
https://doi.org/10.1101/2021.01.19.427283
https://doi.org/10.1101/2021.01.19.427283
Autor:
Vito Conte, Helen K. Matthews, Xavier Trepat, José J. Muñoz, Marina Uroz, Giulia Fornabaio, Agata Nyga, Suze Dercksen, Buzz Baum
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Science Advances, 7(42):eabg6467. American Association for the Advancement of Science (AAAS)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Universidad de Barcelona
Science Advances, 7(42):eabg6467. American Association for the Advancement of Science (AAAS)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor development. Here, we ask how the uniform activation oncogene RAS affects the morphology and tissue mechanics in a normal epithelium. We found th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1cf28cb345e2bef3700bf0a6b41839
http://hdl.handle.net/2445/181240
http://hdl.handle.net/2445/181240