Isolation and substrate dependence on extracellular vesicle characterisation using atomic force microscopy

Autor: Garima Dobhal, Sophie Cottam, Helen Jankowski, Jude Weidenhofer, Renee V Goreham

Publikováno v: Nano Express, Vol 4, Iss 3, p 035003 (2023)

Extracellular vesicles are nano- to micro-sized structures that carry biomolecules between cells to coordinate cellular activity and communication. Isolation and characterisation must be standardised to better understand the role of extracellular ves

Externí odkaz: https://doaj.org/article/baaa67fde1644e1295e42758c5724e30

The Bispidinone Derivative 3,7-Bis-[2-(S)-amino-3-(1H-indol-3-yl)-propionyl]-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one Dihydrochloride Induces an Apoptosis-Mediated Cytotoxic Effect on Pancreatic Cancer Cells In Vitro

Autor: Melanie J. Predebon, Danielle R. Bond, Joshua Brzozowski, Helen Jankowski, Fiona Deane, Mark Tarleton, Aron A. Shaw, Adam McCluskey, Michael C. Bowyer, Judith Weidenhofer, Christopher J. Scarlett

Publikováno v: Molecules, Vol 24, Iss 3, p 524 (2019)

Pancreatic cancer (PC) is a complex, heterogeneous disease with a dismal prognosis. Current therapies have failed to improve survival outcomes, urging the need for discovery of novel targeted treatments. Bispidinone derivatives have yet to be investi

Externí odkaz: https://doaj.org/article/56d49fd19e824b2ab53b775f8ba3d930

Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion

Autor: Martin R. Larsen, Joshua S. Brzozowski, Kathryn A. Skelding, Matthew D. Dun, Rachel Burchell, Danielle R. Bond, Helen Jankowski, Christopher J. Scarlett, Nathan D. Smith, Crystal Naudin, Belinda J. Goldie, Judith Weidenhofer

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Brzozowski, J S, Bond, D R, Jankowski, H, Goldie, B J, Burchell, R, Naudin, C, Smith, N D, Scarlett, C J, Larsen, M R, Dun, M D, Skelding, K A & Weidenhofer, J 2018, ' Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion ', Scientific Reports, vol. 8, 8822 . https://doi.org/10.1038/s41598-018-27180-z

To facilitate intercellular communication, cells release nano-sized, extracellular vesicles (EVs) to transfer biological cargo to both local and distant sites. EVs are enriched in tetraspanins, two of which (CD9 and CD151) have altered expression pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975da3d934a35a8bb2d1f0981ed8842a
http://link.springer.com/article/10.1038/s41598-018-27180-z

The Bispidinone Derivative 3,7-Bis-[2-(S)-amino-3-(1H-indol-3-yl)-propionyl]-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one Dihydrochloride Induces an Apoptosis-Mediated Cytotoxic Effect on Pancreatic Cancer Cells In Vitro

Autor: Danielle R. Bond, Joshua S. Brzozowski, Judith Weidenhofer, Mark Tarleton, Christopher J. Scarlett, Melanie J. Predebon, Aron A Shaw, Michael C. Bowyer, Fiona M. Deane, Adam McCluskey, Helen Jankowski

Publikováno v: Molecules, Vol 24, Iss 3, p 524 (2019)
Molecules
Volume 24
Issue 3

Pancreatic cancer (PC) is a complex, heterogeneous disease with a dismal prognosis. Current therapies have failed to improve survival outcomes, urging the need for discovery of novel targeted treatments. Bispidinone derivatives have yet to be investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa574b458635b630b4d14661f0006b63
https://www.mdpi.com/1420-3049/24/3/524

The Olive Biophenols Oleuropein and Hydroxytyrosol Selectively Reduce Proliferation, Influence the Cell Cycle, and Induce Apoptosis in Pancreatic Cancer Cells

Autor: Christopher J. Scarlett, Costas E. Stathopoulos, Judith Weidenhofer, Chloe D. Goldsmith, Helen Jankowski, Paul D. Roach, Danielle R. Bond

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 7, p 1937 (2018)
International Journal of Molecular Sciences
Volume 19
Issue 7

Current chemotherapy drugs for pancreatic cancer only offer an increase in survival of up to six months. Additionally, they are highly toxic to normal tissues, drastically affecting the quality of life of patients. Therefore, the search for novel age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23657b6053c3da38fec58bc11aa6d3d8
https://doi.org/10.3390/ijms19071937