Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Helen J. Meadows"'
Autor:
Tim Dale, Helen J. Meadows, Andrew J. Powell, Jeffrey J. Clare, Emma C. Hollands, Andrew Baxter, Derek J. Trezise
Publikováno v:
SLAS Discovery. 14:769-780
Gamma-amino butyric acid (GABA)-activated Cl- channels are critical mediators of inhibitory postsynaptic potentials in the CNS. To date, rational design efforts to identify potent and selective GABA(A) subtype ligands have been hampered by the absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16973a6e695ef5455a221d4f19cf91a
https://doi.org/10.1177/1087057109335675
https://doi.org/10.1177/1087057109335675
Publikováno v:
Molecular and Cellular Neuroscience. 37:32-39
Two-pore domain potassium (K(2P)) channels are proposed to underlie the background or leak current found in many excitable cells. Extensive studies have been performed investigating the inhibition of K(2P)2.1 by Galpha(q)- and Galpha(s)-coupled G-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cecf55586f6f3518142c96556fd0e34
https://doi.org/10.1016/j.mcn.2007.08.009
https://doi.org/10.1016/j.mcn.2007.08.009
Autor:
Emma C. Hollands, Derek J. Trezise, Victoria H John, David L. Downie, Mao Xiang Chen, Tim Dale, Leanne Partington, Helen J. Meadows
Publikováno v:
SLAS Discovery. 12:50-60
Planar array electrophysiology techniques were applied to assays for modulators of recombinant hIK and hSK3 Ca2+-activated K+ channels. In CHO-hIK-expressing cells, under asymmetric K+ gradients, small-molecule channel activators evoked time- and vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70bd99a3951d5db183cbed6671267b8
https://doi.org/10.1177/1087057106294920
https://doi.org/10.1177/1087057106294920
Publikováno v:
The Journal of Physiology. 560:51-62
Background potassium channels control the resting membrane potential of neurones and regulate their excitability. Two-pore-domain potassium (2-PK) channels have been shown to underlie a number of such neuronal background currents. Currents through hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98f0c2af579d542edf42b5c148c31165
https://doi.org/10.1113/jphysiol.2004.070292
https://doi.org/10.1113/jphysiol.2004.070292
Autor:
J.E Cluderay, C.W Gray, Paula J. Green, G.J Hervieu, Helen J. Meadows, Jennie L Ranson, Andrew D. Randall
Publikováno v:
Neuroscience. 103:899-919
TREK-1 is a member of the two-pore-domain potassium channel family which is expressed predominantly in the CNS. Using an anti-peptide polyclonal antiserum, we have determined the distribution of TREK-1 in the brain and spinal cord of adult rats. Spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027d5df8998dd9a32b97b1bdd7ccf969
https://doi.org/10.1016/s0306-4522(01)00030-6
https://doi.org/10.1016/s0306-4522(01)00030-6
Autor:
Helen J. Meadows, Andrew D. Randall
Publikováno v:
Neuropharmacology. 40:551-559
Human TASK-3 (hTASK-3) is a recently identified member of the two-pore domain potassium channel (2PDKC) family which in man is predominantly expressed in the cerebellum. Previous preliminary examination of this channel indicates that when expressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b961cb7685befdb79f5a6647f9e029a
https://doi.org/10.1016/s0028-3908(00)00189-1
https://doi.org/10.1016/s0028-3908(00)00189-1
Autor:
Paul R. Murdock, Graham D Smith, Isro S Gloger, John Terrett, Kathryn Ellington, D.Malcolm Duckworth, Andrew D. Medhurst, Amanda J. L. Barton, Mark H Harries, Christopher D. Benham, Martin J. Gunthorpe, Andrew D. Randall, Helen J. Meadows, Simon Topp, David C. Harrison, Rab K. Prinjha, William Cairns, Catherine E. Clarke, Gareth J. Sanger, Owen Jenkins, John B. Davis, Philip David Hayes
Publikováno v:
Pain. 88:205-215
Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we describe the cloning of a human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a232f7dc9ef6d689e3c5c246cf140a
https://doi.org/10.1016/s0304-3959(00)00353-5
https://doi.org/10.1016/s0304-3959(00)00353-5
Autor:
Andrew D. Randall, David A. Campbell, Malcolm Duckworth, Paul R. Murdock, Helen J. Meadows, Conrad Gerald Chapman, Rosemary E. Kelsell, Gillian I. Rennie, Israel S. Gloger, Rob J. Godden
Publikováno v:
Molecular Brain Research. 82:74-83
We have isolated, by degenerate PCR, a complementary DNA encoding a novel two pore domain potassium channel. This is the 7th functional member of the human tandem pore domain potassium channel family to be reported. It has an open reading frame of 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46f5e7630975c8ef1f8627d8698c139
https://doi.org/10.1016/s0169-328x(00)00183-2
https://doi.org/10.1016/s0169-328x(00)00183-2
Publikováno v:
The Journal of Physiology. 523:697-703
1. Effects of external pH on the human P2X4 purinoceptor, an ATP-activated ion channel, were studied using the Xenopus oocyte expression system. 2. Changing the external pH from 7.4 to 6.5 significantly reduced, whilst an increase to pH 8 enhanced, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a93a50dfc0ea140651df8b194321c3
https://doi.org/10.1111/j.1469-7793.2000.00697.x
https://doi.org/10.1111/j.1469-7793.2000.00697.x
Autor:
David O. Carpenter, Gayle Chapman, Jackie Meakin, Catherine E. Clarke, Simon Q. J. Rice, Helen J. Meadows, Stephen J. Brough, Gareth J. Sanger, David C. Harrison, W.Jeff Tomlinson, Robert P. Davis, Martyn D. Wood, Martyn C. Coldwell, Mark Thomas Mchale
Publikováno v:
Neuroscience Letters. 273:183-186
P2X 4 receptors are expressed in specific brain areas. We now describe site-specific splice variations of the human P2X 4 receptor subunit, occurring at residue [YVI G ↓WVFV(W)] near the end of the first predicted transmembrane domain. p2x 4(b) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7841942e313a1bde76530b416b0a382
https://doi.org/10.1016/s0304-3940(99)00653-9
https://doi.org/10.1016/s0304-3940(99)00653-9