Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Helen J. Diggle"'
Autor:
Rodney A. Bednar, Roger M. Freidinger, John A. McCauley, Keith A. Wafford, David A. Claremon, Christopher F. Claiborne, Brian E. Libby, Stuart R. Michelson, Alison J. Macaulay, Nigel J. Liverton, Thomas M. Connolly, Bohumil Bednar, Kenneth S. Koblan, Stanley L. Gaul, Scott D. Mosser, Joseph J. Lynch, Cindra L. Condra, Gary L. Stump, Helen J. Diggle, Janusz Jozef Kulagowski, Kenneth D. Anderson, Neil Roy Curtis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:697-700
A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a carrageenan-induced rat hyperalgesia model of pain and shows no motor coordination side effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd299167537625261e03641a62d5a8a0
https://doi.org/10.1016/s0960-894x(02)01061-2
https://doi.org/10.1016/s0960-894x(02)01061-2
Autor:
Neil Roy Curtis, Emma J. Handford, Christopher Thomson, Janusz Jozef Kulagowski, Helen J. Diggle, Margaret S. Beer
Publikováno v:
ChemInform. 35
A series of thiazole based 5HT(7) ligands has been identified from screening. Optimisation of the pendent aryl group and modification of the core gave a related series of high affinity, selective thiopyridine based 5HT(7) ligands, the most active of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9875e113d4f6c2c59cebae044c6046
https://doi.org/10.1002/chin.200423156
https://doi.org/10.1002/chin.200423156
Autor:
Fraser Murray, Sarah Grimwood, Clare London, Keith A. Wafford, Alison J. Macaulay, Helen J. Diggle, Peter H. Hutson, Pawel Richards, Neil Roy Curtis, Janusz Jozef Kulagowski
Publikováno v:
ChemInform. 34
Novel ( E )- N 1 -(benzyl)cinnamamidines were prepared and evaluated as NR2B subtype NMDA receptor ligands. Excellent affinity was achieved by appropriate substitution of either phenyl ring. The 2-methoxybenzyl compound 1h had ∼1000-fold lower IC 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95478177c03a635a5aff6e1d4a8b65ec
https://doi.org/10.1002/chin.200325110
https://doi.org/10.1002/chin.200325110
Publikováno v:
Carbohydrate research. 293(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7846fbe47020f862a98504fe76a905dc
https://pubmed.ncbi.nlm.nih.gov/8938378
https://pubmed.ncbi.nlm.nih.gov/8938378