Zobrazeno 1 - 10
of 452
pro vyhledávání: '"Helen J, Lachmann"'
Autor:
Jahanzaib Khwaja, Sriram Ravichandran, Joshua Bomsztyk, Oliver Cohen, Darren Foard, Ana Martinez-Naharro, Lucia Venneri, Marianna Fontana, Philip N. Hawkins, Julian Gillmore, Helen J. Lachmann, Shameem Mahmood, Carol Whelan, Amy A. Kirkwood, Ashutosh Wechalekar
Publikováno v:
Haematologica, Vol 109, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/915c492f78c44f6384e3417ca3c0700e
Impact of early response on outcomes in AL amyloidosis following treatment with frontline Bortezomib
Autor:
Sriram Ravichandran, Oliver C. Cohen, Steven Law, Darren Foard, Marianna Fontana, Ana Martinez-Naharro, Carol Whelan, Julian D. Gillmore, Helen J. Lachmann, Sajitha Sachchithanantham, Shameem Mahmood, Philip N. Hawkins, Ashutosh D. Wechalekar
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 6, Pp 1-9 (2021)
Abstract The outcomes in systemic AL amyloidosis are dependent on the depth of haematologic response. However, there is limited data on the impact of the speed of response on outcomes. Here we report the impact of speed of response in a cohort of AL
Externí odkaz:
https://doaj.org/article/b337fd1300e6447c92566346cf8407bf
Autor:
Claire J. Peet, Dorota Rowczenio, Ebun Omoyinmi, Charalampia Papadopoulou, Bella Ruth R. Mapalo, Michael R. Wood, Francesca Capon, Helen J. Lachmann
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 11 (2022)
Background Idiopathic recurrent pericarditis (IRP) is an orphan disease that carries significant morbidity, partly driven by corticosteroid dependence. Innate immune modulators, colchicine and anti‐interleukin‐1 agents, pioneered in monogenic aut
Externí odkaz:
https://doaj.org/article/00cf1fdebe46457a8220df3d186408a1
Autor:
Steven Law, Aviva Petrie, Liza Chacko, Oliver C. Cohen, Sriram Ravichandran, Janet A. Gilbertson, Dorota Rowczenio, Ashutosh Wechalekar, Ana Martinez‐Naharro, Helen J. Lachmann, Carol J. Whelan, David F. Hutt, Philip N. Hawkins, Marianna Fontana, Julian D. Gillmore
Publikováno v:
ESC Heart Failure, Vol 7, Iss 6, Pp 3942-3949 (2020)
Abstract Aims Cardiac transthyretin amyloidosis (ATTR‐CM) is a progressive and fatal condition. Prognosis can be determined at diagnosis according to the National Amyloidosis Centre (NAC) transthyretin amyloidosis (ATTR) stage. We sought to examine
Externí odkaz:
https://doaj.org/article/5ca588ecccb047eab238fa32476e0c62
Autor:
Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.
Externí odkaz:
https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c
Autor:
Suzie Cro, Prakash Patel, Jonathan Barker, David A. Burden, Christopher E. M. Griffiths, Helen J. Lachmann, Nick J. Reynolds, Richard B. Warren, Francesca Capon, Catherine Smith, Victoria Cornelius
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background Current treatment options for Palmoplantar Pustulosis (PPP), a debilitating chronic skin disease which affects the hands and feet, are limited. The Anakinra for Pustular psoriasis: Response in a Controlled Trial (APRICOT) aims to
Externí odkaz:
https://doaj.org/article/8ba3d9e7fa2e4b1a86f539590b8406c9
Autor:
Abdulkadir A. Elmi, Karen Wynne, Iek L. Cheng, Despina Eleftheriou, Helen J. Lachmann, Philip N. Hawkins, Paul Brogan
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 17, Iss 1, Pp 1-7 (2019)
Abstract Background Cryopyrin-associated periodic syndrome (CAPS) is a rare autoinflammatory disease, caused by gain of function mutation in NLRP3 resulting in excess production of interleukin-1 (IL-1). Canakinumab is a human monoclonal antibody agai
Externí odkaz:
https://doaj.org/article/7ce2796f5ba049bfab2d362b6990e6a1
Autor:
Tamer Rezk, Janet A Gilbertson, P Patrizia Mangione, Dorota Rowczenio, Nigel B Rendell, Diana Canetti, Helen J Lachmann, Ashutosh D Wechalekar, Paul Bass, Philip N Hawkins, Vittorio Bellotti, Graham W Taylor, Julian D Gillmore
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 5, Iss 3, Pp 145-153 (2019)
Abstract The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific
Externí odkaz:
https://doaj.org/article/9387814b13b64cdd87bd2fdab0cb78d9
Publikováno v:
Medicine. 51:273-279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eb26862a5ace361825b4576d7f08b4f
https://doi.org/10.1016/j.mpmed.2023.01.009
https://doi.org/10.1016/j.mpmed.2023.01.009
Autor:
Faye A. Sharpley, Marianna Fontana, Ana Martinez-Naharro, Richa Manwani, Shameem Mahmood, Sajitha Sachchithanantham, Helen J. Lachmann, Julian D. Gillmore, Carol J. Whelan, Philip N. Hawkins, Ashutosh D. Wechalekar
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Patients with systemic immunoglobulin light chain amyloidosis (AL) with no evidence of cardiac involvement by consensus criteria have excellent survival, but 20% will die within 5 years of diagnosis and prognostic factors remain poorly characterised.
Externí odkaz:
https://doaj.org/article/4c0d2fdc319441b7ad5798507526abd1