Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Helen I. Gandler"'
Autor:
Moshe Lapidot, Abigail E. Case, Dalia Larios, Helen I. Gandler, Chengcheng Meng, Isidora Tošić, Ellen L. Weisberg, Michael J. Poitras, Prafulla C. Gokhale, Cloud P. Paweletz, Klaus Podar, Ravi Salgia, Srinivas V. Saladi, James D. Griffin, David A. Frank, Raphael Bueno, Martin Sattler
Publikováno v:
Cancers, Vol 13, Iss 1, p 7 (2020)
Malignant pleural mesothelioma (MPM) is an aggressive cancer defined by loss-of-function mutations with few therapeutic options. We examined the contribution of the transcription factor Signal transducer and activator of transcription 3 (STAT3) to ce
Externí odkaz:
https://doaj.org/article/10b34e7dca44438887d6d67db760ebe8
Publikováno v:
Mol Cancer Res
Pancreatic cancer is characterized by aberrant activity of oncogenic KRAS, which is mutated in 90% of pancreatic adenocarcinomas. Because KRAS itself is a challenging therapeutic target, we focused on understanding key signaling pathways driven by KR
Autor:
Patricia A. Toniolo, Kimberly Stegmaier, Ann Mullally, Darwin Q. Ye, Sarah R. Walker, Michelle Tillgren, Gabriela Alexe, Suhu Liu, Radhika Mathur, David A. Frank, Helen I. Gandler, David A. Barbie, Prafulla C. Gokhale, Anna E. Marneth, Katherine Labella
To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e70dbb1d6d1028c0aa5afef3b3e8adc
https://europepmc.org/articles/PMC6290107/
https://europepmc.org/articles/PMC6290107/
Autor:
Andy Yu, Meredith E. Stanhope, Patsy S. Dickinson, Tess J. Lameyer, J. Joe Hull, Devlin Shea, Helen I. Gandler, Andrew E. Christie, Micah G. Pascual
Publikováno v:
Invert Neurosci
The American lobster, Homarus americanus, is a model for investigating the neuromodulatory control of physiology and behavior. Prior studies have shown that multiple classes of chemicals serve as locally released/circulating neuromodulators/neurotran
Autor:
Michael J. Poitras, Dalia Larios, Abigail E Case, David A. Frank, Helen I. Gandler, Srinivas Vinod Saladi, Ellen Weisberg, Prafulla C. Gokhale, Chengcheng Meng, Cloud P. Paweletz, Martin Sattler, James D. Griffin, Raphael Bueno, Isidora Tošić, Moshe Lapidot, Klaus Podar, Ravi Salgia
Publikováno v:
Cancers, Vol 13, Iss 7, p 7 (2021)
Cancers
Volume 13
Issue 1
Cancers
Volume 13
Issue 1
Simple Summary Malignant pleural mesothelioma (MPM) is characterized by the lack of effective long-term treatments and highly prevalent drug resistance. The paucity of potential therapeutic targets has led to dismal prognosis. We have examined the fu
Autor:
Jonathan A. Nowak, Sarah R. Walker, Zachary T. Giaccone, Darwin Q. Ye, Suhu Liu, David A. Frank, Brian M. Wolpin, Helen I. Gandler, Andrew J. Aguirre
Publikováno v:
Cancer Research. 79:B32-B32
One of the hallmarks of pancreatic cancer is aberrant activity of oncogenic KRAS, which is mutated and constitutively activated in greater than 90% of pancreatic adenocarcinomas. While KRAS itself is a challenging therapeutic target, we have focused
Autor:
Kelsey O'Day, Daniel J. DeAngelo, Martha Wadleigh, Eric S. Winer, Ilene Galinsky, Marlise R. Luskin, Jacqueline S. Garcia, David A. Frank, Adrienne Anderson, Ashlee J. Fiore, Geoffrey Fell, Donna Neuberg, Richard Stone, Helen I. Gandler
Publikováno v:
Blood. 134:2549-2549
Background: Increased expression of hepatocyte growth factor (HGF), causing activation of its receptor MET, is found in a subset of patients with acute myeloid leukemia (AML). Inhibition of HGF-MET signaling with the specific MET kinase inhibitor cri
Autor:
Andrew E Christie, Meredith E. Stanhope, Devlin Shea, Matthew C. Cieslak, Vittoria Roncalli, Patsy S. Dickinson, Andy Yu, Tess J. Lameyer, Helen I. Gandler
Publikováno v:
The FASEB Journal. 31