Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Helen I Woodroof"'
Autor:
Atul Kumar, Jevgenia Tamjar, Andrew D Waddell, Helen I Woodroof, Olawale G Raimi, Andrew M Shaw, Mark Peggie, Miratul MK Muqit, Daan MF van Aalten
Publikováno v:
eLife, Vol 6 (2017)
Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain v
Externí odkaz:
https://doaj.org/article/20fff1131a3e4ec08eaeefa1982c53ca
Autor:
Helen I. Woodroof, Matthias Trost, Miratul M. K. Muqit, Chandana Kondapalli, Brian D. Dill, Robert Gourlay, James B. Procter, Aymelt Itzen, Yu-Chiang Lai, Mark Peggie, Olga Corti, Ronny Lehneck, David G. Campbell, Thomas Macartney, Jean-Christophe Corvol
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal, EMBO Press, 2015, 34 (22), pp.2840-2861. 〈10.15252/embj.201591593〉
EMBO Journal, 2015, 34 (22), pp.2840-2861. ⟨10.15252/embj.201591593⟩
EMBO Journal, EMBO Press, 2015, 34 (22), pp.2840-2861. ⟨10.15252/embj.201591593⟩
EMBO Journal
EMBO Journal, EMBO Press, 2015, 34 (22), pp.2840-2861. 〈10.15252/embj.201591593〉
EMBO Journal, 2015, 34 (22), pp.2840-2861. ⟨10.15252/embj.201591593⟩
EMBO Journal, EMBO Press, 2015, 34 (22), pp.2840-2861. ⟨10.15252/embj.201591593⟩
International audience; Mutations in the PTEN-induced kinase 1 (PINK1) are causative of autosomal recessive Parkinson's disease (PD). We have previously reported that PINK1 is activated by mitochondrial depolarisation and phosphorylates serine 65 (Se
Autor:
Daan M. F. van Aalten, Mark Peggie, Andrew D. Waddell, Andrew M. Shaw, Olawale G. Raimi, Atul Kumar, Jevgenia Tamjar, Helen I. Woodroof, Miratul M. K. Muqit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f5fa800988cc3e3a1cefc2af9cbf77
https://doi.org/10.7554/elife.29985.019
https://doi.org/10.7554/elife.29985.019
Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction
Autor:
Helen I. Woodroof, Robert Gourlay, René J. M. Bindels, Maxime G. Blanchard, Thomas Macartney, Jenny van der Wijst, Dario R. Alessi, Joost G. J. Hoenderop
Publikováno v:
Biochemical Journal, 460, 165-75
Biochemical Journal, 460, 2, pp. 165-75
Biochemical Journal
Biochemical Journal, 460, 2, pp. 165-75
Biochemical Journal
Mutations in the gene that encodes the atypical channel-kinase TRPM6 (transient receptor potential melastatin 6) cause HSH (hypomagnesaemia with secondary hypocalcaemia), a disorder characterized by defective intestinal Mg2+ transport and impaired re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e7734bdcb54ec7e84d4a3ebc37e701
http://hdl.handle.net/2066/138516
http://hdl.handle.net/2066/138516
Autor:
Claire E. Allen, Helen I. Woodroof, Aimee McTighe, Miratul M. K. Muqit, Rosemarie Soellner, Reinhard W. Köster, Heather Mortiboys, Philip W. Ingham, Marcus Keatinge, Paul R. Heath, Laura J. Flinn, Andreas S. Reichert, Lucy M. Brown, Sandrine Bretaud, Hideaki Matsui, Elena De Felice, Oliver Bandmann, Marta Milo
Publikováno v:
Annals of Neurology
Autosomal recessively inherited, loss of function mutations in PTEN‐induced kinase 1 (PINK1) typically lead to early onset Parkinson disease (EOPD).1 The PINK1 protein is expressed ubiquitously throughout the human brain.2 Impaired mitochondrial fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e720104adeaf75289299c08269cbcbe
http://hdl.handle.net/11581/405383
http://hdl.handle.net/11581/405383
Autor:
David G. Campbell, Maria Deak, Helen I. Woodroof, Dario R. Alessi, Robert Gourlay, Ning Zhang, Miratul M. K. Muqit, Agne Kazlauskaite, Helen Walden, Axel Knebel, Thomas Macartney, Chandana Kondapalli, Lynn Burchell
Publikováno v:
Open Biology
Open Biology, Vol 2, Iss 5 (2012)
Open Biology, Vol 2, Iss 5 (2012)
Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly phos
Autor:
Helen I. Woodroof, Alexander J. Whitworth, Maria Deak, Mike Begley, Lewis C. Cantley, David G. Campbell, Daan M. F. van Aalten, Joe H. Pogson, Miratul M. K. Muqit, Dario R. Alessi
Publikováno v:
Open Biology, Vol 1, Iss 3 (2011)
Open biology
Open biology
Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-recessive Parkinson's disease. To date, little is known about the intrinsic catalytic properties of PINK1 since the human enzyme displays su
Autor:
Agne Kazlauskaite, Van Kelly, Clare Johnson, Carla Baillie, C. James Hastie, Mark Peggie, Thomas Macartney, Helen I. Woodroof, Dario R. Alessi, Patrick G. A. Pedrioli, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 4, Iss 3 (2014)
Mutations in PINK1 and Parkin are associated with early-onset Parkinson's disease. We recently discovered that PINK1 phosphorylates Parkin at serine65 (Ser65) within its Ubl domain, leading to its activation in a substrate-free activity assay. We now
Externí odkaz:
https://doaj.org/article/58e6e1eca9d44c9f95b5cbdf86b81aff
Autor:
Chandana Kondapalli, Agne Kazlauskaite, Ning Zhang, Helen I. Woodroof, David G. Campbell, Robert Gourlay, Lynn Burchell, Helen Walden, Thomas J. Macartney, Maria Deak, Axel Knebel, Dario R. Alessi, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 2, Iss 5 (2012)
Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly phos
Externí odkaz:
https://doaj.org/article/a7ccab88220e49e2ad360b217db36be0