Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Helen Humphries"'
Autor:
Helen Humphries, Lisa Almond, Alexander Berg, Iain Gardner, Oliver Hatley, Xian Pan, Ben Small, Mian Zhang, Masoud Jamei, Klaus Romero
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1382-1395 (2021)
Abstract Tuberculosis (TB) remains a global health problem and there is an ongoing effort to develop more effective therapies and new combination regimes that can reduce duration of treatment. The purpose of this study was to demonstrate utility of a
Externí odkaz:
https://doaj.org/article/1f55df4e4fa5444cbd1301d827c62ac4
Autor:
Iain Gardner, Oliver Hatley, Lisa Almond, Ben G Small, Klaus Romero, Mian Zhang, Helen Humphries, Xian Pan, Masoud Jamei, Alexander Berg
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1382-1395 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1382-1395 (2021)
Tuberculosis (TB) remains a global health problem and there is an ongoing effort to develop more effective therapies and new combination regimes that can reduce duration of treatment. The purpose of this study was to demonstrate utility of a physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100305f9b2cb1a62052fdbb161a28bd
https://doi.org/10.1002/psp4.12707
https://doi.org/10.1002/psp4.12707
Autor:
Helen Humphries, Udoamaka Ezuruike, Maurice Dickins, Sibylle Neuhoff, Iain Gardner, Karen Rowland Yeo
Publikováno v:
Clinical Pharmacology and Therapeutics
Current formulations of combined oral contraceptives (COC) containing ethinylestradiol (EE) have ≤35 μg due to increased risks of cardiovascular diseases (CVD) with higher doses of EE. Low-dose formulations however, have resulted in increased inci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f3c54233386eb9e1c032cb8499eba5
https://pubmed.ncbi.nlm.nih.gov/29637542
https://pubmed.ncbi.nlm.nih.gov/29637542
Publikováno v:
Metabolite Safety in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca28366c4363c1ea0a8824f2f8e74019
https://doi.org/10.1002/9781118949689.ch8
https://doi.org/10.1002/9781118949689.ch8
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(9)
Prediction accuracy of pharmacokinetic parameters is often assessed using prediction fold error, i.e., being within 2-, 3-, or n-fold of observed values. However, published studies disagree on which fold error represents an accurate prediction. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b51e0b38d80e41a7ff33e78069ecf6
https://pubmed.ncbi.nlm.nih.gov/24989891
https://pubmed.ncbi.nlm.nih.gov/24989891
Autor:
Niloufar Marsousi, Caroline Flora Samer, Helen Humphries, Jules Alexandre Desmeules, Youssef Daali, Serge Rudaz, L. Almond
Publikováno v:
CPT: pharmacometrics & systems pharmacology, Vol. 3 (2014) P. e152
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Evaluation of a potential risk of metabolic drug–drug interactions (DDI) is of high importance in the clinical setting. In this study, a physiologically based pharmacokinetic (PBPK) model was developed for oxycodone and its two primary metabolites,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4880daa0ccf8dae169c00f81aa46d02
https://archive-ouverte.unige.ch/unige:54963
https://archive-ouverte.unige.ch/unige:54963
Autor:
Pierre Dayer, Helen Humphries, Caroline Flora Samer, Niloufar Marsousi, Jules Alexandre Desmeules, Youssef Daali, L. Almond
Publikováno v:
Clinical Therapeutics. (8):e76
PP189—A PhySiologiCAlly-BASed MeChANiSTiC PhArMACokiNeTiC Model To ASSeSS The MeTABoliSM of oxyCodoNe iN heAlThy VoluNTeerS: iNTerPlAy BeTweeN CyP3A ANd 2d6 iNhiBiTioN N. Marsousi; Y. Daali; H. Humphries; L. Almond; P. Dayer; J. Desmeules; and C. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb11f9d068cdb59df99bbd7c302a961