Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Helen Hilton"'
Autor:
Thomas Agnew, Michelle Goldsworthy, Carlos Aguilar, Anna Morgan, Michelle Simon, Helen Hilton, Chris Esapa, Yixing Wu, Heather Cater, Liz Bentley, Cheryl Scudamore, Joanna Poulton, Karl J. Morten, Kyle Thompson, Langping He, Steve D.M. Brown, Robert W. Taylor, Michael R. Bowl, Roger D. Cox
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3315-3328.e6 (2018)
Summary: Mutations in genes essential for mitochondrial function have pleiotropic effects. The mechanisms underlying these traits yield insights into metabolic homeostasis and potential therapies. Here we report the characterization of a mouse model
Externí odkaz:
https://doaj.org/article/630a0a3d696840bfb3f385b49f594bbc
Autor:
Pam Siggers, Gwenn-Aël Carré, Debora Bogani, Nick Warr, Sara Wells, Helen Hilton, Chris Esapa, Mohammad K Hajihosseini, Andy Greenfield
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100447 (2014)
The secreted molecule fibroblast growth factor 9 (FGF9) plays a critical role in testis determination in the mouse. In embryonic gonadal somatic cells it is required for maintenance of SOX9 expression, a key determinant of Sertoli cell fate. Conditio
Externí odkaz:
https://doaj.org/article/b46f7a2ea5db4085af07bdc27de8d884
Autor:
Michael T Cheeseman, Hayley E Tyrer, Debbie Williams, Tertius A Hough, Paras Pathak, Maria R Romero, Helen Hilton, Sulzhan Bali, Andrew Parker, Lucie Vizor, Tom Purnell, Kate Vowell, Sara Wells, Mahmood F Bhutta, Paul K Potter, Steve D M Brown
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002336 (2011)
Otitis media with effusion (OME) is the commonest cause of hearing loss in children, yet the underlying genetic pathways and mechanisms involved are incompletely understood. Ventilation of the middle ear with tympanostomy tubes is the commonest surgi
Externí odkaz:
https://doaj.org/article/12d63bc415b249f7b612e2389bb1acab
Autor:
Philomena Mburu, María Rosario Romero, Helen Hilton, Andrew Parker, Stuart Townsend, Yoshiaki Kikkawa, Steve D M Brown
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11627 (2010)
A complex of proteins scaffolded by the PDZ protein, whirlin, reside at the stereocilia tip and are critical for stereocilia development and elongation. We have shown that in outer hair cells (OHCs) whirlin is part of a larger complex involving the M
Externí odkaz:
https://doaj.org/article/8b684e3814bb4e2ba5caa60f61807aa3
Autor:
Jimena Perez-Sanchez, Steven J. Middleton, Luke A. Pattison, Helen Hilton, Mosab Ali Awadelkareem, Sana R. Zuberi, Maria B. Renke, Huimin Hu, Xun Yang, Alex J. Clark, Ewan St, John Smith, David L. Bennett
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means to suppress such excitability, yet chemogenetic approaches suitable for human applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a201550328dc67e8ff53193ad20a64
https://doi.org/10.1101/2023.03.21.533690
https://doi.org/10.1101/2023.03.21.533690
Autor:
Kavindiya Modarage, Paraskevi Goggolidou, Charlotte H. Dean, Christopher T. Esapa, Patricia D. Wilson, Aidan McCarthy-Boxer, Helen Hilton, Jill T. Norman, Taylor Richards
Publikováno v:
Biochimica et Biophysica Acta. Molecular Basis of Disease
Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a genetic disorder with an incidence of ~1:20,000 that manifests in a wide range of renal and liver disease severity in human patients and can lead to perinatal mortality. ARPKD is caused by mu
Autor:
Roger D. Cox, Michael R. Bowl, Cheryl L. Scudamore, Karl J. Morten, Michelle Goldsworthy, Steve D.M. Brown, Robert W. Taylor, Anna Morgan, Helen Hilton, Christopher T. Esapa, Heather Cater, Joanna Poulton, Kyle Thompson, Michelle Simon, Langping He, Yixing Wu, Liz Bentley, Thomas Agnew, Carlos A. Aguilar
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3315-3328.e6 (2018)
Cell Reports
Cell Reports
Summary Mutations in genes essential for mitochondrial function have pleiotropic effects. The mechanisms underlying these traits yield insights into metabolic homeostasis and potential therapies. Here we report the characterization of a mouse model h
Autor:
Ying Bai, David Lloyd, Helen Hilton, Chi-Ming Li, Edwin Lamas, Will Baron, Daniel M. Baker, Roger D. Cox, Michelle Goldsworthy, Murielle M. Véniant, Todd Juan, Christopher T. Esapa, Huanying Ge
Insulin resistance in mice typically does not manifest as diabetes due to multiple compensatory mechanisms. Here, we present a novel digenic model of type 2 diabetes in mice heterozygous for a null allele of the insulin receptor and an N-ethyl-N-nitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbf9034b0f1f8f16ba9109f743fb3f0
https://europepmc.org/articles/PMC5947768/
https://europepmc.org/articles/PMC5947768/
Autor:
Kerry-Lyn Riley, Pam Siggers, Michelle Simon, Nicola Powles-Glover, Daniel T. Grimes, Debora Bogani, Helen Hilton, Andy Greenfield, Dominic P. Norris, Sarah Field
Publikováno v:
Development. 138:1131-1142
In mammals, left-right (L-R) asymmetry is established by posteriorly oriented cilia driving a leftwards laminar flow in the embryonic node, thereby activating asymmetric gene expression. The two-cilia hypothesis argues that immotile cilia detect and
Autor:
Andrew Sunters, Peter Underhill, Joanna S. Price, Lance E. Lanyon, Leanne Saxon, Gul Zaman, Debbie Williams, Helen Hilton
Publikováno v:
Bone
Loading-related changes in gene expression in resident cells in the tibia of female mice in the contexts of normality (WT), estrogen deficiency (WT-OVX), absence of estrogen receptor alpha (ERalpha(-/-)) and disuse due to sciatic neurectomy (WT-SN) w