Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Helen H, Won"'
Autor:
Ezra Y. Rosen, Helen H. Won, Youyun Zheng, Emiliano Cocco, Duygu Selcuklu, Yixiao Gong, Noah D. Friedman, Ino de Bruijn, Onur Sumer, Craig M. Bielski, Casey Savin, Caitlin Bourque, Christina Falcon, Nikeysha Clarke, Xiaohong Jing, Fanli Meng, Catherine Zimel, Sophie Shifman, Srusthi Kittane, Fan Wu, Marc Ladanyi, Kevin Ebata, Jennifer Kherani, Barbara J. Brandhuber, James Fagin, Eric J. Sherman, Natasha Rekhtman, Michael F. Berger, Maurizio Scaltriti, David M. Hyman, Barry S. Taylor, Alexander Drilon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The results of the phase 1/2 LIBRETTO-001 clinical trial has recently established the efficacy of the RET inhibitor selpercatinib in RET-driven cancers. Here, the authors characterize the molecular determinants of response and resistance in 72 LIBRET
Externí odkaz:
https://doaj.org/article/c9aadc1f6bbc44acba731c2a7dcb7aef
Autor:
Nina Radosevic-Robin, Pier Selenica, Yingjie Zhu, Helen H. Won, Michael F. Berger, Lorenzo Ferrando, Emiliano Cocco, Maud Privat, Flora Ponelle-Chachuat, Catherine Abrial, Jean-Marc Nabholtz, Frederique Penault-Llorca, Jorge S. Reis-Filho, Maurizio Scaltriti
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract To find metastatic recurrence biomarkers of triple-negative breast cancer (TNBC) treated by neoadjuvant chemotherapy and anti-EGFR antibodies (NAT), we evaluated tumor genomic, transcriptomic, and immune features, using MSK-IMPACT assay, gen
Externí odkaz:
https://doaj.org/article/5085bbfc4563442588c40da205b8c222
Autor:
Ezra Y. Rosen, Helen H. Won, Youyun Zheng, Emiliano Cocco, Duygu Selcuklu, Yixiao Gong, Noah D. Friedman, Ino de Bruijn, Onur Sumer, Craig M. Bielski, Casey Savin, Caitlin Bourque, Christina Falcon, Nikeysha Clarke, Xiaohong Jing, Fanli Meng, Catherine Zimel, Sophie Shifman, Srushti Kittane, Fan Wu, Marc Ladanyi, Kevin Ebata, Jennifer Kherani, Barbara J. Brandhuber, James Fagin, Eric J. Sherman, Natasha Rekhtman, Michael F. Berger, Maurizio Scaltriti, David M. Hyman, Barry S. Taylor, Alexander Drilon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5da51ab03db947f7a3ffd0a6118bb43a
Autor:
Triparna Sen, Charles M. Rudin, Richard P. Koche, Brian Loomis, John T. Poirier, Natasha Rekhtman, Marina K. Baine, Elisa de Stanchina, Juan Qiu, Helena A. Yu, Travis J. Hollmann, Michael H. Roehrl, Christine A. Iacobuzio-Donahue, Joachim Silber, Sonali Sinha, Marina Asher, Irina Linkov, Umesh K. Bhanot, Jacklynn Egger, Sam E. Tischfield, Jordana Ray-Kirton, Jason C. Chang, Michael Offin, Andrew Chow, Metamia Ciampricotti, Joseph M. Chan, Helen H. Won, Mark T.A. Donoghue, Parvathy Manoj, Fathema Uddin, Fanli Meng, Shweta S. Chavan, Maysun M. Hasan, Yingqian A. Zhan, Hirokazu Taniguchi, Alvaro Quintanal-Villalonga
Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung adenocarcinomas (LUAD) amenable to targeted therapy, transformation to small cell lung cancer (SCLC) is a recognized resistance mechanism. Defining molecular mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19866bcbfca6f0bd1b206c8dae81ff58
https://doi.org/10.1158/2159-8290.c.6549461
https://doi.org/10.1158/2159-8290.c.6549461
Autor:
David M. Hyman, Funda Meric-Bernstam, David B. Solit, Barry S. Taylor, José Baselga, Richard Bryce, Alshad S. Lalani, Melanie Dujka, Lisa D. Eli, Feng Xu, Grace Mann, Maurizio Scaltriti, Yanyan Cai, Aliaksandra Samoila, Myra Melcer, S. Duygu Selcuklu, Catherine Zimel, Elena I. Gavrila, Komal Jhaveri, Sarat Chandarlapaty, Gary A. Ulaner, Rebecca J. Nagy, Richard B. Lanman, Alexander N. Gorelick, François-Clement Bidard, Andrés Cervantes, Xavier Gonzàlez-Farré, Lee S. Schwartzberg, Joohyuk Sohn, Valentina Boni, Victor Moreno, Monica Arnedos, Morten Mau-Sørensen, Iben Spanggaard, Adam M. Brufksy, Macarena I. de la Fuente, Carlos L. Arteaga, Ingrid A. Mayer, Dejan Juric, Geoffrey I. Shapiro, Janice Lu, Sherene Loi, Cristina Saura, Alison M. Schram, Helen H. Won, Sarina A. Piha-Paul, Lillian M. Smyth
Overall sequencing CONSORT diagram. Flow diagram of study patients and analyzed biospecimens processed through and selected for central sequencing using MSK-IMPACT and Guardant360. cfDNA, cell-free DNA; FFPE, formalin-fixed paraffin-embedded; MSK-IMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadd31b50eb28b778540b40ef3547376
https://doi.org/10.1158/2159-8290.22535392.v1
https://doi.org/10.1158/2159-8290.22535392.v1
Autor:
Maurizio Scaltriti, Alexander Drilon, Andrea Ventura, Chandra S. Verma, Elisa de Stanchina, Moshe Elkabets, David M. Hyman, Jaclyn F. Hechtman, Alberto Bardelli, Barry S. Taylor, Sandra Misale, Uwe Rix, Yi Liao, Sankar Jagadeeshan, Ofra Novoplansky, Michael F. Berger, Alexander N. Gorelick, Neil Vasan, Ram Kannan, Benedetta Mussolin, Sabrina Arena, Yanyan Cai, Fan Wu, Srushti Kittane, Amaia Arruabarrena-Aristorena, Eneda Toska, Laura Baldino, Amanda Kulick, Sophie Shifman, Helen H. Won, Alison M. Schram, Srinivasaraghavan Kannan, Ji Eun Lee, Emiliano Cocco
On-target resistance to next-generation TRK inhibitors in TRK fusion–positive cancers is largely uncharacterized. In patients with these tumors, we found that TRK xDFG mutations confer resistance to type I next-generation TRK inhibitors designed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807ca77bc7845326b9d1552aaed59835
https://doi.org/10.1158/2159-8290.c.6548215.v1
https://doi.org/10.1158/2159-8290.c.6548215.v1
Autor:
David M. Hyman, Funda Meric-Bernstam, David B. Solit, Barry S. Taylor, José Baselga, Richard Bryce, Alshad S. Lalani, Melanie Dujka, Lisa D. Eli, Feng Xu, Grace Mann, Maurizio Scaltriti, Yanyan Cai, Aliaksandra Samoila, Myra Melcer, S. Duygu Selcuklu, Catherine Zimel, Elena I. Gavrila, Komal Jhaveri, Sarat Chandarlapaty, Gary A. Ulaner, Rebecca J. Nagy, Richard B. Lanman, Alexander N. Gorelick, François-Clement Bidard, Andrés Cervantes, Xavier Gonzàlez-Farré, Lee S. Schwartzberg, Joohyuk Sohn, Valentina Boni, Victor Moreno, Monica Arnedos, Morten Mau-Sørensen, Iben Spanggaard, Adam M. Brufksy, Macarena I. de la Fuente, Carlos L. Arteaga, Ingrid A. Mayer, Dejan Juric, Geoffrey I. Shapiro, Janice Lu, Sherene Loi, Cristina Saura, Alison M. Schram, Helen H. Won, Sarina A. Piha-Paul, Lillian M. Smyth
HER2 mutations define a subset of metastatic breast cancers with a unique mechanism of oncogenic addiction to HER2 signaling. We explored activity of the irreversible pan-HER kinase inhibitor neratinib, alone or with fulvestrant, in 81 patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df3c52be345cb95e67d14e31497f606f
https://doi.org/10.1158/2159-8290.c.6547849.v1
https://doi.org/10.1158/2159-8290.c.6547849.v1
Autor:
Maurizio Scaltriti, Alexander Drilon, Andrea Ventura, Chandra S. Verma, Elisa de Stanchina, Moshe Elkabets, David M. Hyman, Jaclyn F. Hechtman, Alberto Bardelli, Barry S. Taylor, Sandra Misale, Uwe Rix, Yi Liao, Sankar Jagadeeshan, Ofra Novoplansky, Michael F. Berger, Alexander N. Gorelick, Neil Vasan, Ram Kannan, Benedetta Mussolin, Sabrina Arena, Yanyan Cai, Fan Wu, Srushti Kittane, Amaia Arruabarrena-Aristorena, Eneda Toska, Laura Baldino, Amanda Kulick, Sophie Shifman, Helen H. Won, Alison M. Schram, Srinivasaraghavan Kannan, Ji Eun Lee, Emiliano Cocco
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509bc17855bc29dcb35a2805f934c54c
https://doi.org/10.1158/2159-8290.22536730.v1
https://doi.org/10.1158/2159-8290.22536730.v1
Autor:
Triparna Sen, Charles M. Rudin, Richard P. Koche, Brian Loomis, John T. Poirier, Natasha Rekhtman, Marina K. Baine, Elisa de Stanchina, Juan Qiu, Helena A. Yu, Travis J. Hollmann, Michael H. Roehrl, Christine A. Iacobuzio-Donahue, Joachim Silber, Sonali Sinha, Marina Asher, Irina Linkov, Umesh K. Bhanot, Jacklynn Egger, Sam E. Tischfield, Jordana Ray-Kirton, Jason C. Chang, Michael Offin, Andrew Chow, Metamia Ciampricotti, Joseph M. Chan, Helen H. Won, Mark T.A. Donoghue, Parvathy Manoj, Fathema Uddin, Fanli Meng, Shweta S. Chavan, Maysun M. Hasan, Yingqian A. Zhan, Hirokazu Taniguchi, Alvaro Quintanal-Villalonga
Supplemental figures and figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cdf6100787567edd1d3c55a0d31bc8
https://doi.org/10.1158/2159-8290.22540724
https://doi.org/10.1158/2159-8290.22540724
Autor:
David M. Hyman, Funda Meric-Bernstam, David B. Solit, Barry S. Taylor, José Baselga, Richard Bryce, Alshad S. Lalani, Melanie Dujka, Lisa D. Eli, Feng Xu, Grace Mann, Maurizio Scaltriti, Yanyan Cai, Aliaksandra Samoila, Myra Melcer, S. Duygu Selcuklu, Catherine Zimel, Elena I. Gavrila, Komal Jhaveri, Sarat Chandarlapaty, Gary A. Ulaner, Rebecca J. Nagy, Richard B. Lanman, Alexander N. Gorelick, François-Clement Bidard, Andrés Cervantes, Xavier Gonzàlez-Farré, Lee S. Schwartzberg, Joohyuk Sohn, Valentina Boni, Victor Moreno, Monica Arnedos, Morten Mau-Sørensen, Iben Spanggaard, Adam M. Brufksy, Macarena I. de la Fuente, Carlos L. Arteaga, Ingrid A. Mayer, Dejan Juric, Geoffrey I. Shapiro, Janice Lu, Sherene Loi, Cristina Saura, Alison M. Schram, Helen H. Won, Sarina A. Piha-Paul, Lillian M. Smyth
Supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9a66139c86c7fc9c7963ce2aff13cc
https://doi.org/10.1158/2159-8290.22535398
https://doi.org/10.1158/2159-8290.22535398