Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Helen Gilchrest"'
Publikováno v:
Biochemical and Biophysical Research Communications. 332:17-27
The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist. Studies suggest that P2X7 has a potentially pivotal role in inflammatory responses largely stemming from its role in mediating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d23580136848bc26a51cb86b0773c31
https://doi.org/10.1016/j.bbrc.2005.04.087
https://doi.org/10.1016/j.bbrc.2005.04.087
Autor:
Scott Greenfeder, Sergio A. Lira, H. Jones, Ted T. Kung, Helen Gilchrest, B. Luo, John C. Anthes, Richard W. Chapman, Donald N. Cook, John A. Hey, Maria T. Wiekowski, Robert W. Egan, Yvette Crawley
Publikováno v:
Pharmacological Research. 50:611-615
Tachykinins are important in the development of pulmonary inflammation in mice but the tachykinin receptor subtype mediating this response has not been defined. To elucidate the role of tachykinin NK 3 -receptors on allergen-induced pulmonary inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc3ecb414910a07b9e556ee0a1f6e1e
https://doi.org/10.1016/j.phrs.2004.07.002
https://doi.org/10.1016/j.phrs.2004.07.002
Autor:
Robert E. West, Helen Gilchrest, Scott Greenfeder, Robert W. Egan, Christian Richard, Stephen Eckel, John C. Anthes, William Kreutner, M. Motasim Billah, Shirley M. Williams, Dave Hesk
Publikováno v:
European Journal of Pharmacology. 449:229-237
We have characterized desloratadine (5 H -benzo[5,6]cyclohepta[1,2- b ]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene), CAS 100643-71-8) as a potent antagonist of the human histamine H 1 receptor. [ 3 H]Desloratadine bound to membranes expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7736ad2a5c68fd0bfb9c6b8d675332cd
https://doi.org/10.1016/s0014-2999(02)02049-6
https://doi.org/10.1016/s0014-2999(02)02049-6
Autor:
M. Motasim Billah, Helen Gilchrest, Ziran Zhan, John C. Anthes, Marvin I. Siegel, Robert W. Egan
Publikováno v:
Biochemical Journal. 309:175-180
The effects of interferon-alpha (IFN-alpha) on the interleukin-6 (IL-6) receptor in a multiple myeloma cell line, U266, have been examined. IFN-alpha inhibits [3H]thymidine incorporation in U266 cells in a time- and dose-dependent manner. Furthermore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98112191e8ac66b192e3bff657c1a237
https://doi.org/10.1042/bj3090175
https://doi.org/10.1042/bj3090175
Autor:
Helen Gilchrest, M. Motasim Billah, Scott Greenfeder, Robert W. Egan, John C. Anthes, Boonlert Cheewatrakoolpong
Publikováno v:
Life sciences. 73(20)
Mast cells are the central mediating cells of allergic reactions. Binding of allergen specific IgE to high affinity IgE receptor (Fcepsilon RI) and subsequent binding of allergen by the IgE causes receptor cross-linking and activation. In a study exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b70d5a22adc454bf0a0f9259186f482
https://pubmed.ncbi.nlm.nih.gov/12967681
https://pubmed.ncbi.nlm.nih.gov/12967681
Autor:
Scott Greenfeder, Boonlert Cheewatrakoolpong, John C. Anthes, M M Billah, Stephen Eckel, Robert W. Egan, Helen Gilchrest
Publikováno v:
BioTechniques. 34(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612ad99b0ba218b70b962f2be3dffa15
https://pubmed.ncbi.nlm.nih.gov/12765013
https://pubmed.ncbi.nlm.nih.gov/12765013
Autor:
Helen Gilchrest, Chin-Chung Lin, Robert W. Egan, M. Motasim Billah, Mitchell N. Cayen, Hong-Ki Kim, John C. Anthes
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 15(3)
Inhibiting the action of platelet-activating factor (PAF) is a new therapeutic approach for the treatment of allergic disorders. SCH 44643 is a new orally-active antagonist of response to both PAF and histamine. This study was done to determine plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a928b73ae3c287fa402e1602bb0ca14d
https://pubmed.ncbi.nlm.nih.gov/8951694
https://pubmed.ncbi.nlm.nih.gov/8951694
Autor:
J David Christopher, M. Motasim Billah, Paul J Lawton, Catherine A Granzow, Helen Gilchrest, Marvin I. Siegel, Stephen Eckel, W. Richards, Elaine Radwanski, Melton B. Affrime, Melvin D. Brannan
Publikováno v:
Clinical pharmacology and therapeutics. 52(2)
Preclinical studies have established that Sch 37370 (1-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]-cyclohepta [1,2-b]pyridin-11-ylidene)piperidine) is an orally active antagonist of platelet-activating factor (PAF) and histamine H1-receptors with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cddff2e120f37d86f0c6ac2994ad285
https://pubmed.ncbi.nlm.nih.gov/1505150
https://pubmed.ncbi.nlm.nih.gov/1505150
Publikováno v:
Biochemical and Biophysical Research Communications. 342:1004
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2afa04e54e28134c85032e90e19938b
https://doi.org/10.1016/j.bbrc.2006.02.038
https://doi.org/10.1016/j.bbrc.2006.02.038
Autor:
Arthur S. Watnick, Helen Gilchrest
Publikováno v:
Agents and Actions. 7:529-532
The relationship between leucocyte mobilization and edema formation was evaluated in the carrageenan pleurisy model. In normal rats carrageenan was able to mobilize between 80 and 100 million cells per ml of fluid. In neutropenic rats the concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31783895318ab87294952d1efad25b81
https://doi.org/10.1007/bf02111125
https://doi.org/10.1007/bf02111125