Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Helen Francis-Lang"'
Autor:
Gregory D. Plowman, Casey Kopczynski, Kim Lickteig, Lori Friedman, Christopher G. Winter, Matt B. Mahoney, Kellie Whittaker, Helen Francis-Lang, Marcia Belvin, Matthew V. Lorenzi, Ferhad Ahmad, Hanife Esengil, Annette L. Parks, Brent A. Rupnow, Monique Nicoll, Feng Chen, Lynn M. Young, Mariano Tabios, Kyle A. Edgar, Christopher C. Park, Amanda Norton, Laleh Shayesteh, Pamela M. Carroll
Publikováno v:
Genetics. 170:161-171
Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65091c5d6b43aa177e96872e9a4ef058
https://doi.org/10.1534/genetics.104.036343
https://doi.org/10.1534/genetics.104.036343
Autor:
Jennifer E Deal, Geoffrey Duyk, Kyle A. Edgar, Kevin P Bogart, Christopher G. Winter, Matthew A Singer, Daniel Tim Curtis, Robert Fawcett, Lory R Tan, Valentina Vysotskaia, Wesley Y Miyazaki, Casey Kopczynski, Kari Huppert, Marie Marcinko, Elizabeth Howie, Millicent A Winner, Doua Thao, Kellie Whittaker, Nicholas A Dompe, Jonathan Margolis, Deanna Grant, Rachel S. Andrade, Gregory D. Plowman, Marcia Belvin, Mariano Tabios, Megan E Deal-Herr, Helen Francis-Lang, Amanda Norton, Lora Zhao, Stephanie A. Robertson, Annette L. Parks, Lori Friedman, Kenneth J. Shaw, Kevin R. Cook, Keith Killpack, Brett Milash, Thomas C. Kaufman
Publikováno v:
Nature Genetics. 36:288-292
In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most widely used deletions were generated by irradiation or chemical mutagenesis. These methods are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477f9bbffc7978d9ed6722537bf31237
https://doi.org/10.1038/ng1312
https://doi.org/10.1038/ng1312
Autor:
Ross Buchholz, Jonathan Margolis, Kimberly Greer, Carol M. Singh, Lory R Tan, Lynn M Stevens, Cathy Erickson, Julie Mazzotta, Wesley Y Miyazaki, Lora Zhao, Angela Chong, Robert Fawcett, William W Fisher, Lai Man Cheung, Keith Killpack, Alex Laufer, Geoffrey Duyk, Stephen T Thibault, Candace Swimmer, Matthew A Singer, Helen Francis-Lang, Casey Kopczynski, Elizabeth Howie, Lakshmi Jakkula, Madelyn Robin Demsky, Brett Milash, Irena Zakrajsek, Richard Benn Abegania Ventura, Feng Chen, Nicholas A Dompe, Margaret L. Winberg, Alesa Woo, Lisa Ryner, Daniel Joo, Ronald D. Smith, Stephanie R Hartouni, Christiana Stuber
Publikováno v:
Nature Genetics. 36:283-287
With the availability of complete genome sequence for Drosophila melanogaster, one of the next strategic goals for fly researchers is a complete gene knockout collection. The P-element transposon, the workhorse of D. melanogaster molecular genetics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790ac1443a02e6b74ca89a02a2a92ea2
https://doi.org/10.1038/ng1314
https://doi.org/10.1038/ng1314
Autor:
Ilan Davis, Yatish Lad, Helen Francis-Lang, William Sullivan, Gavin S. Wilkie, Nina MacDougall
Publikováno v:
Development. 128:665-673
In Drosophila, the formation of the embryonic axes is initiated by Gurken, a transforming growth factor α signal from the oocyte to the posterior follicle cells, and an unknown polarising signal back to the oocyte. We report that Drosophila Merlin i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91fdc39ad369c9dec4c8f96ad1752c0
https://doi.org/10.1242/dev.128.5.665
https://doi.org/10.1242/dev.128.5.665
Autor:
Sabbi Lall, David Ish-Horowicz, Trudi Schüpbach, Amanda Norvell, Helen Francis-Lang, Antonin Flament
Publikováno v:
Cell. 98(2):171-180
Drosophila melanogaster pair-rule segmentation gene transcripts localize apically of nuclei in blastoderm embryos. This might occur by asymmetric (vectorial) export from one side of the nucleus or by transport within the cytoplasm. We have followed f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e1fe4943eaca90cb1811b4ceaa498b
Autor:
Roberto DiLauro, Alena Donda, Françoise N. Javaux, Helen Francis-Lang, Fabien Bertaux, Gilbert Vassart, Daniel Christophe
Publikováno v:
FEBS Letters. 300:222-226
We have studied the binding of purified TTF-1 on the bovine thyroglobulin gene promoter. DNase I footprinting experiments revealed three binding sites which corresponded in location to the A, B and C sites found in the rat thyroglobulin promoter. Mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf2576de2c40cd18b6de45a8237eda6
https://doi.org/10.1016/0014-5793(92)80850-g
https://doi.org/10.1016/0014-5793(92)80850-g
Autor:
Gregory D. Plowman, D Baly, L Johnson, Michael Costa, Lori Friedman, Helen Francis-Lang, Geoffrey Duyk
Publikováno v:
BASE-Bielefeld Academic Search Engine
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Genetic screens can reveal new pathway modifier genes that would be difficult to uncover using other experimental approaches. The conservation of biochemical pathways and ability to quickly screen large numbers of candidate target genes strongly supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7770718da891a03f618c6547c91f383
https://doi.org/10.1186/bcr717
https://doi.org/10.1186/bcr717
Publikováno v:
Mechanisms of development. 51(2-3)
In Drosophila, maternal string mRNAs are stable for the first few hours of development, but undergo specific timed degradation at the cellularisation stage. To determine whether the proteins that control this degradation are maternally or zygotically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4f4002e1121d483baabb95f2f48ba4
https://pubmed.ncbi.nlm.nih.gov/7547469
https://pubmed.ncbi.nlm.nih.gov/7547469