Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Helen Eachus"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Exposure to excess glucocorticoid (GC) during early development is implicated in adult dysfunctions. Reduced adult hippocampal neurogenesis is a well-known consequence of exposure to early life stress or elevated GC, however the effects on n
Externí odkaz:
https://doaj.org/article/19150303a853495d86dc99c45c134c21
Autor:
Min-Kyeung Choi, Alexander Cook, Kanak Mungikar, Helen Eachus, Anna Tochwin, Matthias Linke, Susanne Gerber, Soojin Ryu
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110160- (2024)
Summary: Early life stress (ELS) is a major risk factor for developing psychiatric disorders, with glucocorticoids (GCs) implicated in mediating its effects in shaping adult phenotypes. In this process, exposure to high levels of developmental GC (hd
Externí odkaz:
https://doaj.org/article/02720797642941e0a2fce22a09a4bec9
Autor:
Helen Eachus, Lara Oberski, Jack Paveley, Irina Bacila, John-Paul Ashton, Umberto Esposito, Fayaz Seifuddin, Mehdi Pirooznia, Eran Elhaik, Marysia Placzek, Nils P. Krone, Vincent T. Cunliffe
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/aa67d866b66e45b491817fdc22250015
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The early life period represents a window of increased vulnerability to stress, during which exposure can lead to long-lasting effects on brain structure and function. This stress-induced developmental programming may contribute to the behavioural ch
Externí odkaz:
https://doaj.org/article/b0d8d5ba68a34e5a949d9b7cf3573078
Exposure to excess glucocorticoid (GC) during early development is implicated in adult dysfunctions. Reduced adult hippocampal neurogenesis is a well-known consequence of exposure to early life stress or elevated GC, however the effects on neurogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::590ad56b2c83c25ae0206a1113a0798f
https://doi.org/10.1101/2023.01.27.525966
https://doi.org/10.1101/2023.01.27.525966
Organisms respond to stressors through a coordinated set of physiological and behavioural responses. Zebrafish provides an opportunity to study conserved mechanisms underlying the stress-response that is regulated largely by the neuroendocrine Hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc317a0fe18db72748b4d3f4ca9e27bb
https://doi.org/10.1101/2022.09.09.507267
https://doi.org/10.1101/2022.09.09.507267
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 26:100383
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d736da0c83341bede207dc4339909e5f
https://doi.org/10.1016/j.coemr.2022.100383
https://doi.org/10.1016/j.coemr.2022.100383
Autor:
Nils Krone, John-Paul Ashton, Kieran Berntsen, Harriet E. Jackson, Mehdi Pirooznia, Umberto Esposito, Marysia Placzek, Eran Elhaik, Fayaz Seifuddin, Vincent T. Cunliffe, Richard A. Baines, Guannyu Wang, Helen Eachus, Dheemanth Subramanya
The Glucocorticoid Receptor (GR) co-ordinates metabolic and behavioural responses to stressors. We hypothesised that GR influences behaviour by modulating specific epigenetic and transcriptional processes in the brain. Using the zebrafish as a model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2674f90223d8d21e53ab2fac1b3183bf
Autor:
Huda Adwan-Shekhidem, Gil Atzmon, Bérénice A. Benayoun, John D. Bowman, Kim V.E. Braun, Ramón Cacabelos, Paola Caiafa, Xiaohua Cao, Mahua Choudhury, Rajiv Chowdhury, Fabio Ciccarone, Vincent T. Cunliffe, Weiwei Dang, Xiao Dong, Helen Eachus, Oscar H. Franco, Silvia Gravina, Alexander K. Koliada, Igor Kovalchuk, Tilen Kranjc, Anna Kudryavtseva, Vineet Kumar, Simon C. Langley-Evans, Wil A.M. Loenen, Nika Lovšin, Oleh V. Lushchak, Janja Marc, Sunitha Meruvu, Ken I. Mills, Arnold B. Mitnitski, Alexey Moskalev, Beverly S. Muhlhausler, Taulant Muka, Jana Nano, Justin M. O’Sullivan, Barbara Ostanek, Eliana Portilla, Ken Raj, Irene M. Rea, Clare M. Reynolds, Axel Schumacher, Robert A. Seaborne, Stephanie A. Segovia, Mikhail Shaposhnikov, Adam P. Sharples, Ilya Solovev, Claire E. Stewart, Oscar Teijido, Jenna Troup, Duygu Ucar, Alexander M. Vaiserman, Mukesh Verma, Mark H. Vickers, Jan Vijg, Trudy Voortman, Xiangru Xu, Michele Zampieri, Janja Zupan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659a973da7210f3bab7a5e2f66303963
https://doi.org/10.1016/b978-0-12-811060-7.01002-0
https://doi.org/10.1016/b978-0-12-811060-7.01002-0
Autor:
Helen Eachus, Vincent T. Cunliffe
We provide an overview of recent progress in elucidating the epigenetic mechanisms through which the impacts of psychosocial stressors become biologically embedded, thereby influencing physiology and modulating disease susceptibility. We focus on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a4cf04b58652f7b75d7fe9ef7319e45
https://doi.org/10.1016/b978-0-12-811060-7.00012-7
https://doi.org/10.1016/b978-0-12-811060-7.00012-7