Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Helen E. MacLean"'
Publikováno v:
Asian Journal of Andrology, Vol 16, Iss 5, Pp 675-683 (2014)
We aimed to determine the mechanisms of the anabolic actions of androgens in skeletal muscle by investigating potential androgen receptor (AR)-regulated genes in in vitro and in vivo models. The expression of the myogenic regulatory factor myogenin w
Externí odkaz:
https://doaj.org/article/0423724d02004b39a172e95b5ea11064
Autor:
Nhu Y.N. Nguyen, Giovanna Pomilio, David J. Curtis, Matthew P. McCormack, Andrew H. Wei, Helen E. MacLean, Wan Sze Chiu, Rachel A Davey, Julie McManus, Jeffrey D Zajac
Publikováno v:
European journal of haematologyREFERENCES. 105(3)
Background Androgens function through DNA and non-DNA binding-dependent signalling of the androgen receptor (AR). How androgens promote erythropoiesis is not fully understood. Design and methods To identify the androgen signalling pathway, we treated
Autor:
Jarrod P Skinner, Maria Ws Chiu, Barbara C Fam, Nicole K. L. Lee, Kesha Rana, Patricia K Russell, Jeffrey D Zajac, Helen E. MacLean
Publikováno v:
Journal of Molecular Endocrinology. 57:125-138
The aim of this study was to investigate the direct muscle cell-mediated actions of androgens by comparing two different mouse lines. The cre-loxP system was used to delete the DNA-binding activity of the androgen receptor (AR) in mature myofibers (M
Autor:
Helen E. MacLean, Barbara C Fam, Tammy P S Pang, Jeffrey D Zajac, Kesha Rana, Michele V Clarke
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 301:E767-E778
In men, as testosterone levels decrease, fat mass increases and muscle mass decreases. Increased fat mass in men, in particular central obesity, is a major risk factor for type 2 diabetes, cardiovascular disease, and all-cause mortality. Testosterone
Publikováno v:
Journal of Endocrinological Investigation. 31:910-918
Androgens have anabolic actions in skeletal muscle and could potentially act to: (a) increase proliferation of myoblasts; (b) delay differentiation to myotubes; and (c) induce protein accretion in post-proliferative myofibers. To identify the site of
Autor:
W.S. Maria Chiu, Rachel A Davey, Cathy Ma, Helen E. MacLean, Rhoda Cameron, Jeffrey D Zajac, Amanda J. Notini, Julie F. McManus
Publikováno v:
Physiological Genomics. 33:133-137
We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor ( AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR kno
Autor:
David J. Handelsman, Jeffrey D Zajac, David R. Plant, Mark Jimenez, Helen E. MacLean, Leah J. Harcourt, Anna-Maree Axell, Jennifer Ann Davis, Gordon S. Lynch
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 291:E506-E516
Androgens promote anabolism in skeletal muscle; however, effects on subsequent muscle function are less well defined because of a lack of reliable experimental models. We established a rigorous model of androgen withdrawal and administration in male
Publikováno v:
Human Mutation. 27:483-489
We have characterized an unusual family with two different androgen receptor (AR) gene deletions, in which we propose a novel mechanism of deletion formation has occurred. Affected individuals have the X-linked disorder androgen insensitivity syndrom
Autor:
Henry M. Kronenberg, Helen E. MacLean
Publikováno v:
Development, Growth and Differentiation. 47:59-63
We have developed a useful approach to examine the pattern of gene expression in comparison to cell proliferation, using double in situ hybridization and immunofluorescence. Using this system, we examined the expression of Indian hedgehog (Ihh) and P
Autor:
Henry M. Kronenberg, Ekaterina Semenova, David Cobrinik, Carol S. Lin, Richard O. Francis, Ferdinand Rossi, Helen E. MacLean, Wei Yuan
Publikováno v:
Developmental Biology. 247(2):271-285
During endochondral bone development, both the chondrogenic differentiation of mesenchyme and the hypertrophic differentiation of chondrocytes coincide with the proliferative arrest of the differentiating cells. However, the mechanisms by which diffe