Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Helen E. Gruber"'
Publikováno v:
BMC Musculoskeletal Disorders, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Background Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. Little is currently kn
Externí odkaz:
https://doaj.org/article/9639b09d0bc3450c93a98f083999c4a8
Autor:
Helen E. Gruber, Edward N. Hanley, Jr.
Publikováno v:
Biomarker Insights, Vol 1, Pp 131-133 (2006)
Disc degeneration plays a major role in this country's medical, social and economic structure. The life-time prevalence of low back pain, which has disc degeneration as its cause, is about 80% in the general population. It is a primary cause of disab
Externí odkaz:
https://doaj.org/article/b692bc9b77e24712b0edca30e91518af
Publikováno v:
Journal of Pediatric Orthopaedics. 38:e634-e639
BACKGROUND Physeal fractures and resultant physeal bars can pose significant problems in skeletal development for the injured growing child. Although now well-recognized, only a small body of experimental literature covering this problem is available
Autor:
Helen E. Gruber, Audrey A. Stasky
Publikováno v:
Animal Models in Orthopaedic Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d4d570dcc5c861e62693676601b981d
https://doi.org/10.1201/9780429173479-9
https://doi.org/10.1201/9780429173479-9
Publikováno v:
Biotechnichistochemistry : official publication of the Biological Stain Commission. 94(7)
Interleukin-23 (IL-23, IL-23p19) is a proinflammatory cytokine in the IL-12-related family. Although inflammatory cells in herniated discs have been shown to contain IL-23, little is known about the presence and role of IL-23 in human disc cells. We
Autor:
Megan Templin, Jane A. Ingram, Michael Cox, Nomaan Ashraf, Helen E. Gruber, John Michael Wattenbarger
Publikováno v:
Journal of pediatric orthopedics. 39(9)
Background Although physeal fractures and physeal bars can result in significant clinical consequences to growth and development of the injured physis, little orthopaedic research has focused upon this topic. Our objective was to extend a previously
Autor:
Edward N. Hanley, Helen E. Gruber
Publikováno v:
Biotechnic & Histochemistry. 93:109-117
We investigated whether the multifunctional intercellular proteoglycan, serglycin, is expressed in human intervertebral disc cells and assessed its localization. We also investigated expression levels of serglycin in human annulus fibrosus (annulus)
Autor:
Helen E. Gruber, Edward N. Hanley
Publikováno v:
Biotechnic & Histochemistry. 92:402-410
The sand rat, a member of the gerbil family, is a valuable small animal model in which intervertebral disc degeneration occurs spontaneously as the animal ages. Radiographic features of cervical and lumbar degeneration resemble those in human spines.
Publikováno v:
Biotechnic & Histochemistry. 92:222-229
The importance of cytokines in disc degeneration is well recognized. Little is known about IL-22 expression in the human intervertebral disc. We investigated IL-22 immuno-localization in disc tissue, and molecular expression and production of IL-22 b
Publikováno v:
Biotechnic & Histochemistry. 92:7-14
Chemokines are an important group of soluble molecules with specialized functions in inflammation. The roles of many specialized chemokines and their receptors remain poorly understood in the human intervertebral disc. We investigated CXCL16 and its