Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Helen E. Farrell"'
Autor:
Timothy M. White, Cassandra M. Bonavita, Brent A. Stanfield, Helen E. Farrell, Nicholas J. Davis-Poynter, Rhonda D. Cardin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionHuman cytomegalovirus (HCMV) is a global health threat due to its ubiquity and lifelong persistence in infected people. During latency, host CD8+ T cell responses to HCMV continue to increase in a phenomenon known as memory inflation. We
Externí odkaz:
https://doaj.org/article/c87dadf823af4304ab314e47f09eee9b
Autor:
Cassandra M. Bonavita, Timothy M. White, Joseph Francis, Helen E. Farrell, Nicholas J. Davis-Poynter, Rhonda D. Cardin
Publikováno v:
Viruses, Vol 15, Iss 3, p 711 (2023)
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that infects the majority of the world population and causes lifelong latent infection. HCMV has been shown to exacerbate cardiovascular diseases, including myocarditis, vascular sclerosis, and tr
Externí odkaz:
https://doaj.org/article/ad5039dbe4f946b296189f56cfd5e5bd
Autor:
Kimberley Bruce, Jiawei Ma, Clara Lawler, Wanxiaojie Xie, Philip G. Stevenson, Helen E. Farrell
Publikováno v:
Viruses, Vol 14, Iss 9, p 1934 (2022)
Animal models that mimic human infections provide insights in virus–host interplay; knowledge that in vitro approaches cannot readily predict, nor easily reproduce. Human cytomegalovirus (HCMV) infections are acquired asymptomatically, and primary
Externí odkaz:
https://doaj.org/article/bc09440087224838a2f494ba7ec4ad92
Publikováno v:
Viruses, Vol 14, Iss 2, p 391 (2022)
Human cytomegalovirus (HCMV) encodes four homologs of G protein coupled receptors (vGPCRs), of which two, designated UL33 and US28, signal constitutively. UL33 and US28 are also conserved with chemokine receptors: US28 binds numerous chemokine classe
Externí odkaz:
https://doaj.org/article/d6dc8e50b839447b9f8e1ad345cd0dd9
Autor:
Helen E. Farrell, Kimberley Bruce, Clara Lawler, Martha Oliveira, Rhonda Cardin, Nicholas Davis-Poynter, Philip G. Stevenson
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Herpesviruses have coevolved with their hosts over hundreds of millions of years and exploit fundamental features of their biology. Cytomegaloviruses (CMVs) colonize blood-borne myeloid cells, and it has been hypothesized that systemic disse
Externí odkaz:
https://doaj.org/article/cc989069964647c2914a504ec5d01fe3
Autor:
Helen E. Farrell, Clara Lawler, Cindy S. E. Tan, Kate MacDonald, Kimberley Bruce, Michael Mach, Nick Davis-Poynter, Philip G. Stevenson
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Viruses transmit via the environmental and social interactions of their hosts. Herpesviruses have colonized mammals since their earliest origins, suggesting that they exploit ancient, common pathways. Cytomegaloviruses (CMVs) are assumed to
Externí odkaz:
https://doaj.org/article/016a55497c7043a9b8cb9be9fd9c940a
Autor:
Wanxiaojie Xie, Byungchul Lee, Kimberley Bruce, Clara Lawler, Helen E. Farrell, Philip G. Stevenson
Publikováno v:
J Virol
CD4(+) T cells are key to controlling cytomegalovirus infections. Salivary gland infection by murine cytomegalovirus (MCMV) provides a way to identify mechanisms. CD11c(+) dendritic cells (DC) disseminate MCMV to the salivary glands, where they trans
Publikováno v:
J Virol
Common to all cytomegalovirus (CMV) genomes analyzed to date is the presence of G protein-coupled receptors (GPCR). Animal models of CMV provide insights into their role in viral fitness. The mouse cytomegalovirus (MCMV) GPCR, M33, facilitates dendri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a10d55597c1e570fdc23df7231abe79
https://europepmc.org/articles/PMC8865439/
https://europepmc.org/articles/PMC8865439/
Publikováno v:
Journal of General Virology. 100:1695-1700
Cytomegaloviruses (CMVs) use myeloid cells to move within their hosts. Murine CMV (MCMV) colonizes the salivary glands for long-term shedding, and reaches them via CD11c+ infected cells. A need to recruit patrolling monocytes for systemic spread has
Publikováno v:
J Virol
Vaccination against the betaherpesvirus, human cytomegalovirus (HCMV) is a public health goal. However, HCMV has proved difficult to vaccinate against. Vaccination against single HCMV determinants has not worked, suggesting that immunity to a wider a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e120eac3c3b87341ed5386e613f4562a
https://europepmc.org/articles/PMC8513469/
https://europepmc.org/articles/PMC8513469/