Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Helen E. Burston"'
Autor:
Oliver A. Kent, Manipa Saha, Etienne Coyaud, Helen E. Burston, Napoleon Law, Keith Dadson, Sujun Chen, Estelle M. Laurent, Jonathan St-Germain, Ren X. Sun, Yoshinori Matsumoto, Justin Cowen, Aaryn Montgomery-Song, Kevin R. Brown, Charles Ishak, Jose La Rose, Daniel D. De Carvalho, Housheng Hansen He, Brian Raught, Filio Billia, Peter Kannu, Robert Rottapel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mutations in RAS-MAPK pathway genes are implicated in Noonan-spectrum, yet up to 20% of cases have unknown cause. Here, the authors identify RREB1 underlying a 6p microdeletion RASopathy-like syndrome and show that RREB1, SIN3A and KDM1A form a trans
Externí odkaz:
https://doaj.org/article/7477dd54517347169cc4551af1667746
Autor:
Helen E. Burston, Oliver A. Kent, Ren X. Sun, Justin Cowen, Daniel D. De Carvalho, Sujun Chen, Jonathan St-Germain, Robert Rottapel, Aaryn Montgomery-Song, Manipa Saha, Yoshinori Matsumoto, Napoleon Law, Housheng Hansen He, Kevin R. Brown, Peter Kannu, Jose La Rose, Keith Dadson, Charles A. Ishak, Filio Billia, Etienne Coyaud, Brian Raught, Estelle M.N. Laurent
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, Nature Communications, 11 (4673), ⟨10.1038/s41467-020-18483-9⟩
Nature Communications
Nature Communications, 2020, Nature Communications, 11 (4673), ⟨10.1038/s41467-020-18483-9⟩
RAS-MAPK signaling mediates processes critical to normal development including cell proliferation, survival, and differentiation. Germline mutation of RAS-MAPK genes lead to the Noonan-spectrum of syndromes. Here, we present a patient affected by a 6
Autor:
Anne-Marie Mes-Masson, Molly L. Udaskin, Ren X. Sun, Euihye Jung, Kevin R. Brown, Laudine Communal, Jose La Rose, Ronny Drapkin, Joshua K. Lowitz, Kyle E. Francis, Helen E. Burston, Oliver A. Kent, Robert Rottapel
Publikováno v:
J Clin Invest
Ovarian cancer (OC) is the most deadly gynecological malignancy, with unmet clinical need for new therapeutic approaches. The relaxin peptide is a pleiotropic hormone with reproductive functions in the ovary. Relaxin induces cell growth in several ty
Publikováno v:
Oncotarget
// Oliver A. Kent 1 , Maria-Jose Sandi 1 , Helen E. Burston 1 , Kevin R. Brown 2 , Robert Rottapel 1, 3, 4, 5, 6 1 Princess Margaret Cancer Centre, University Health Network, Toronto Medical Discovery Tower, University of Toronto, Toronto, Canada 2 D
Autor:
Elizabeth Conibear, Michael Davey, Beverly Wendland, Shawn T. Whitfield, Lymarie Maldonado-Báez, Nandini Raghuram, Helen E. Burston, Björn D. M. Bean
Publikováno v:
Molecular Biology of the Cell
Adaptor complexes are important for cargo sorting in clathrin-coated vesicles. The µ adaptor subunits Apm1 and Apm2 create functionally distinct versions of the yeast AP-1 complex. A novel regulatory protein is identified that selectively binds Apm2
Autor:
Michael Davey, Joyce Li, Elizabeth Conibear, Olha Hnatshak, Thanuja Punna, Helen E. Burston, Jamie Snider, Shamanta Chandran, Yuen Yi C. Tam, Jack Greenblatt, James Vlasblom, Navgeet Bajaj, Mohan Babu, Chris Graham, Victoria Wong, Franco J. Vizeacoumar, Björn D. M. Bean, Shoshana J. Wodak, Gouqing Zhong, Analyn Yu, Shuye Pu, Vincent Fong, Xinghua Guo, Constantine Christopolous, Andrew Emili, Igor Stagljar, Sadhna Phanse
Publikováno v:
Nature. 489:585-589
Macromolecular assemblies involving membrane proteins (MPs) serve vital biological roles and are prime drug targets in a variety of diseases. Large-scale affinity purification studies of soluble-protein complexes have been accomplished for diverse mo
Autor:
Mauricio Medrano, Helen E. Burston, Daphna Mokady, Kyle E. Francis, Robert Rottapel, Melany J. Wagner
Publikováno v:
Clinical Cancer Research. 24:IA27-IA27
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and whole-kinome proteomics t
Autor:
Beverly Wendland, Elizabeth Conibear, Cayetana Schluter, Michael Davey, Benjamen Montpetit, Lymarie Maldonado-Báez, Helen E. Burston
Publikováno v:
The Journal of Cell Biology
Endocytosis of receptors at the plasma membrane is controlled by a complex mechanism that includes clathrin, adaptors, and actin regulators. Many of these proteins are conserved in yeast yet lack observable mutant phenotypes, which suggests that yeas
Autor:
Elizabeth Conibear, Beverly Wendland, Cayetana Schluter, Benjamen Montpetit, Helen E. Burston, Michael Davey, Lymarie Maldonado-Báez
Publikováno v:
The FASEB Journal. 23
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 457
The transport of membrane-bound proteins through post-Golgi compartments depends on the coordinated function of multiple genes that direct the recognition and routing of protein cargoes to their final cellular destination. As many of these sorting co