Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Helen E. Bryant"'
Autor:
Ingrid M. Saldana-Guerrero, Luis F. Montano-Gutierrez, Katy Boswell, Christoph Hafemeister, Evon Poon, Lisa E. Shaw, Dylan Stavish, Rebecca A. Lea, Sara Wernig-Zorc, Eva Bozsaky, Irfete S. Fetahu, Peter Zoescher, Ulrike Pötschger, Marie Bernkopf, Andrea Wenninger-Weinzierl, Caterina Sturtzel, Celine Souilhol, Sophia Tarelli, Mohamed R. Shoeb, Polyxeni Bozatzi, Magdalena Rados, Maria Guarini, Michelle C. Buri, Wolfgang Weninger, Eva M. Putz, Miller Huang, Ruth Ladenstein, Peter W. Andrews, Ivana Barbaric, George D. Cresswell, Helen E. Bryant, Martin Distel, Louis Chesler, Sabine Taschner-Mandl, Matthias Farlik, Anestis Tsakiridis, Florian Halbritter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we empl
Externí odkaz:
https://doaj.org/article/869f81138e26465185ec2a1246dd0cf6
Autor:
Maria Rita Fabbrizi, Catherine M. Nickson, Jonathan R. Hughes, Emily A. Robinson, Karthik Vaidya, Carlos P. Rubbi, Andrzej Kacperek, Helen E. Bryant, Thomas Helleday, Jason L. Parsons
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-11 (2024)
Abstract Complex DNA damage (CDD), containing two or more DNA lesions within one or two DNA helical turns, is a signature of ionising radiation (IR) and contributes significantly to the therapeutic effect through cell killing. The levels and complexi
Externí odkaz:
https://doaj.org/article/bdd467c30ad140acbe7ccbdc5be68022
Autor:
Caitlin E. Jackson, Iona Doyle, Hamood Khan, Samuel F. Williams, Betül Aldemir Dikici, Edgar Barajas Ledesma, Helen E. Bryant, William R. English, Nicola H. Green, Frederik Claeyssens
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Tumour survival and growth are reliant on angiogenesis, the formation of new blood vessels, to facilitate nutrient and waste exchange and, importantly, provide a route for metastasis from a primary to a secondary site. Whilst current models can ensur
Externí odkaz:
https://doaj.org/article/6e434095490c4230bbdd3443b1e0c64b
Autor:
Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.
Externí odkaz:
https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Photodynamic therapy (PDT) is a treatment which uses light-activated compounds to produce reactive oxygen species, leading to membrane damage and cell death. Multicellular cancer spheroids are a preferable alternative for PDT evaluation in comparison
Externí odkaz:
https://doaj.org/article/6faf31abb00f4d7f9326770db671e41d
Autor:
David King, Harriet E. D. Southgate, Saskia Roetschke, Polly Gravells, Leona Fields, Jessica B. Watson, Lindi Chen, Devon Chapman, Daniel Harrison, Daniel Yeomanson, Nicola J. Curtin, Deborah A. Tweddle, Helen E. Bryant
Publikováno v:
Cancers, Vol 13, Iss 24, p 6215 (2021)
Despite intensive high-dose multimodal therapy, high-risk neuroblastoma (NB) confers a less than 50% survival rate. This study investigates the role of replication stress in sensitivity to inhibition of Ataxia telangiectasia and Rad3-related (ATR) in
Externí odkaz:
https://doaj.org/article/a5f1b96522f9471497b05a2182315205
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins. PARPs are known to function in a large range of cellular processes including DNA r
Externí odkaz:
https://doaj.org/article/04d95c5d2ace4596acecc99477fb1506
Publikováno v:
Cancers, Vol 11, Iss 9, p 1278 (2019)
Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE) is
Externí odkaz:
https://doaj.org/article/ff4b78ecc80f464fa425505d2aa4d92e
Autor:
Salem A. E. Omar, Paul A. Scattergood, Luke K. McKenzie, Helen E. Bryant, Julia A. Weinstein, Paul I. P. Elliott
Publikováno v:
Molecules, Vol 21, Iss 10, p 1382 (2016)
The complex [Os(btzpy)2][PF6]2 (1, btzpy = 2,6-bis(1-phenyl-1,2,3-triazol-4-yl)pyridine) has been prepared and characterised. Complex 1 exhibits phosphorescence (λem = 595 nm, τ = 937 ns, φem = 9.3% in degassed acetonitrile) in contrast to its kno
Externí odkaz:
https://doaj.org/article/9d97af2c6ed44777acbcd32bd4076905
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268300 (2022)
Chemoresistance poses a great barrier to breast cancer treatment and is thought to correlate with increased matrix stiffness. We developed two-dimensional (2D) polyacrylamide (PAA) and three-dimensional (3D) alginate in vitro models of tissue stiffne
Externí odkaz:
https://doaj.org/article/eda66da8f4c74a25a7443d5701b3abd4