Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Helen E Rich"'
Autor:
Helen E Rich, Danielle Antos, Collin C McCourt, Wen Quan Zheng, Louis J Devito, Kevin J McHugh, Radha Gopal, Jieru Wang, John F Alcorn
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0255309 (2021)
BackgroundType III interferon, or interferon lambda (IFNλ) is a crucial antiviral cytokine induced by influenza infection. While IFNλ is important for anti-viral host defense, published data demonstrate that IFNλ is pathogenic during influenza/bac
Externí odkaz:
https://doaj.org/article/164f797b44ad4746969acad593a6ba44
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year. Asthmatics display different phenotypes with distinct genetic components, environmental causes, and immunop
Externí odkaz:
https://doaj.org/article/c6ed1f71163340b8906ff507c432fe6d
Autor:
Radha Gopal, Benjamin Lee, Kevin J. McHugh, Helen E. Rich, Krishnaveni Ramanan, Sivanarayana Mandalapu, Michelle E. Clay, Philip J. Seger, Richard I. Enelow, Michelle L. Manni, Keven M. Robinson, Javier Rangel-Moreno, John F. Alcorn
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. We have previously shown that influenza
Externí odkaz:
https://doaj.org/article/c296759483a54f1c982c9edb7a45130c
Autor:
Radha Gopal, Angelico Mendy, Michael A. Marinelli, Lacee J. Richwalls, Philip J. Seger, Shivani Patel, Kevin J. McHugh, Helen E. Rich, Jennifer A. Grousd, Erick Forno, John F. Alcorn
Publikováno v:
Viruses, Vol 11, Iss 6, p 505 (2019)
Influenza virus is among the most common causes of respiratory illness worldwide and can be complicated by secondary bacterial pneumonia, a frequent cause of mortality. When influenza virus infects the lung, the innate immune response is activated, a
Externí odkaz:
https://doaj.org/article/70bb46a450d244358957415554cf76d4
Autor:
Collin C. McCourt, Jieru Wang, Radha Gopal, John F. Alcorn, Kevin J. McHugh, Louis J Devito, Wen Quan Zheng, Danielle Antos, Helen E. Rich
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0255309 (2021)
PLoS ONE, Vol 16, Iss 10, p e0255309 (2021)
Background Type III interferon, or interferon lambda (IFNλ) is a crucial antiviral cytokine induced by influenza infection. While IFNλ is important for anti-viral host defense, published data demonstrate that IFNλ is pathogenic during influenza/ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db02ad195473398a755dd89f6b22db41
http://europepmc.org/articles/PMC8496871
http://europepmc.org/articles/PMC8496871
Autor:
Marianna A. Ortiz, Keven M. Robinson, Kevin J. McHugh, Robert N. Abood, Derek Pociask, Joshua M. Tobin, John F. Alcorn, Michelle L. Manni, Helen E. Rich, Jay K. Kolls, Jennifer M. Bomberger, Krishnaveni Ramanan
Publikováno v:
Mucosal immunology
Secondary bacterial pneumonia is a significant complication of severe influenza infection and Staphylococcus aureus and Streptococcus pneumoniae are the primary pathogens of interest. IL-22 promotes S. aureus and S. pneumoniae host defense in the lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918643b781c482b0043143d9d5cb69e3
https://doi.org/10.1038/s41385-019-0188-7
https://doi.org/10.1038/s41385-019-0188-7
Autor:
Kevin J. McHugh, Helen E. Rich, Michelle E. Clay, Krishnaveni Ramanan, John F. Alcorn, Keven M. Robinson
Publikováno v:
Mucosal immunology
Influenza A is a highly contagious respiratory virus that causes seasonal epidemics and occasional worldwide pandemics. The primary cause of influenza-related mortality is bacterial superinfection. There are numerous mechanisms by which preceding inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251827f9629ac379b3e2b8303413f1a4
http://europepmc.org/articles/PMC5638662
http://europepmc.org/articles/PMC5638662
Publikováno v:
Clin Microbiol Rev
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Despite broad literature including basic and translational scientific studies, many gaps in our understanding of host-pathogen interactions remain. In this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6590e21b105872e160096427df99c700
https://pubmed.ncbi.nlm.nih.gov/31142498
https://pubmed.ncbi.nlm.nih.gov/31142498
Publikováno v:
C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a27e83f601909cbcf67ec8d2f4e182
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5599
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5599
Autor:
Kevin J. McHugh, Helen E. Rich, Collin C. McCourt, Keven M. Robinson, John F. Alcorn, Wen Quan Zheng, Jieru Wang
Publikováno v:
Infection and immunity. 87(5)
Influenza kills 30,000 to 40,000 people each year in the United States and causes 10 times as many hospitalizations. A common complication of influenza is bacterial superinfection, which exacerbates morbidity and mortality from the viral illness. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935ec68af5200b0892ad04b5cf7d3c60
https://pubmed.ncbi.nlm.nih.gov/30804099
https://pubmed.ncbi.nlm.nih.gov/30804099