Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Helen E Thomas"'
Autor:
Prerak Trivedi, Gaurang Jhala, David J. De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W. Kay, Helen E. Thomas, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibitin
Externí odkaz:
https://doaj.org/article/0e2a9e262b5049768e050d08ba434b1c
Autor:
Kay K. Myo Min, Darling Rojas-Canales, Daniella Penko, Mark DeNichilo, Michaelia P. Cockshell, Charlie B. Ffrench, Emma J. Thompson, Olof Asplund, Christopher J. Drogemuller, Rashmi B. Prasad, Leif Groop, Shane T. Grey, Helen E. Thomas, Thomas Loudovaris, Thomas W. Kay, My G. Mahoney, Claire F. Jessup, P. Toby Coates, Claudine S. Bonder
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-15 (2022)
Abstract Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune processes and β-cell dysfunction are known to occur in type 1 diabetes, a compl
Externí odkaz:
https://doaj.org/article/afcc41530a1443548bde1470cff8d8ab
Autor:
Balasubramanian Krishnamurthy, Matthew Lacorcia, Thomas W. H. Kay, Helen E. Thomas, Stuart I. Mannering
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease. Short-term treatment with agents targeting T cells, B cells and inflammatory cytokines to modify the disease course resulted in a short-term pause in disease activity. Lessons learnt from
Externí odkaz:
https://doaj.org/article/0e1b8fe12e0848439e27932c9bce2a87
Autor:
David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is challenging to study mechanistically in humans because it is not possible to
Externí odkaz:
https://doaj.org/article/6fda57144c434ff1bfc7c70a1820ea51
Autor:
Jacqueline V. Schiesser, Thomas Loudovaris, Helen E. Thomas, Andrew G. Elefanty, Edouard G. Stanley
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The identification of cell surface markers specific to pancreatic beta cells is important for both the study of islet biology and for investigating the pathophysiology of diseases in which this cell type is lost or damaged. Following analysi
Externí odkaz:
https://doaj.org/article/dcab1ff3fe334cd4b5b2b617cf023918
Autor:
Reena Singh, Louise Cottle, Thomas Loudovaris, Di Xiao, Pengyi Yang, Helen E. Thomas, Melkam A. Kebede, Peter Thorn
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 492-505 (2021)
Abstract The differentiation of human stem cells into insulin secreting beta‐like cells holds great promise to treat diabetes. Current protocols drive stem cells through stages of directed differentiation and maturation and produce cells that secre
Externí odkaz:
https://doaj.org/article/cfa6e3d4150c4d1cb7c754e68272f765
Autor:
Anojian Koneshamoorthy, Dilan Seniveratne-Epa, Genevieve Calder, Matthew Sawyer, Thomas W. H. Kay, Stephen Farrell, Thomas Loudovaris, Lina Mariana, Davis McCarthy, Ruqian Lyu, Xin Liu, Peter Thorn, Jason Tong, Lit Kim Chin, Margaret Zacharin, Alison Trainer, Shelby Taylor, Richard J. MacIsaac, Nirupa Sachithanandan, Helen E. Thomas, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
We present a case of an obese 22-year-old man with activating GCK variant who had neonatal hypoglycemia, re-emerging with hypoglycemia later in life. We investigated him for asymptomatic hypoglycemia with a family history of hypoglycemia. Genetic tes
Externí odkaz:
https://doaj.org/article/4a69cf2b5644469b9f635ac9052ea7b7
Autor:
Tingting Ge, Amber‐Lee Phung, Gaurang Jhala, Prerak Trivedi, Nicola Principe, David J De George, Evan G Pappas, Sara Litwak, Laura Sanz‐Villanueva, Tara Catterall, Stacey Fynch, Louis Boon, Thomas W Kay, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Objectives Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune‐related adverse events, including type 1 diabetes (T1D). Our aim was to test whether a JAK1/JAK2 inhibitor, effect
Externí odkaz:
https://doaj.org/article/2f238a260da54aefb12d7ef799742c6b
Autor:
Sarah K. Popp, Federica Vecchio, Debra J. Brown, Riho Fukuda, Yuri Suzuki, Yuma Takeda, Rikako Wakamatsu, Mahalakshmi A. Sarma, Jessica Garrett, Anna Giovenzana, Emanuele Bosi, Antony R.A. Lafferty, Karen J. Brown, Elizabeth E. Gardiner, Lucy A. Coupland, Helen E. Thomas, Beng H. Chong, Christopher R. Parish, Manuela Battaglia, Alessandra Petrelli, Charmaine J. Simeonovic
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Platelet-neutrophil aggregates (PNAs) facilitate neutrophil activation and migration and could underpin the recruitment of neutrophils to the pancreas during type 1 diabetes (T1D) pathogenesis. PNAs, measured by flow cytometry, were significantly ele
Externí odkaz:
https://doaj.org/article/6ed7806b9e764fde908116c406bf2ddb
Autor:
Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G. Pappas, Xin Liu, John W. Scott, Jonathan S. Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L. Eizirik, D. Ross Laybutt, Herbert Herzog, Helen E. Thomas, Kim Loh
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101413- (2022)
Objectives: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D). We have previously reported that the inhibition of the neuropeptide Y1 receptor improves the islet transplantation ou
Externí odkaz:
https://doaj.org/article/02909523106a409cb9dc517663f1220c