Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Helen E, Jolin"'
Autor:
Paula A. Clark, Mayuri Gogoi, Noe Rodriguez-Rodriguez, Ana C. F. Ferreira, Jane E. Murphy, Jennifer A. Walker, Alastair Crisp, Helen E. Jolin, Jacqueline D. Shields, Andrew N. J. McKenzie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Innate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during infection and inflammation. Here we identify, by using combinatorial reporter mice, a rare ILC progenitor (ILCP) population, resident to the small intest
Externí odkaz:
https://doaj.org/article/c71615789fe8474da7ea50ebd878945a
Autor:
Laurence S. C. Lok, Jennifer A. Walker, Helen E. Jolin, Seth T. Scanlon, Masaru Ishii, Padraic G. Fallon, Andrew N. J. McKenzie, Menna R. Clatworthy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s are also present in lymph nodes
Externí odkaz:
https://doaj.org/article/2c7b2790aff8439283a064b67e45a006
Autor:
Aydan C. H. Szeto, Ana C. F. Ferreira, Jonathan Mannion, Paula A. Clark, Meera Sivasubramaniam, Morgan W. D. Heycock, Alastair Crisp, Helen E. Jolin, Patrycja Kozik, Martin D. Knolle, Andrew N. J. McKenzie
Publikováno v:
Nature Immunology. 24:123-135
Naive CD4+ T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression profiles shaped by intercellular microenvironmental cues, resulting in pathogen-focused modular cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ca346888af10ae90e6e3c4740b1495
https://doi.org/10.1038/s41590-022-01378-w
https://doi.org/10.1038/s41590-022-01378-w
Autor:
Bernhard Kerscher, Jillian L. Barlow, Batika M. Rana, Helen E. Jolin, Mayuri Gogoi, Michelle A. Bartholomew, Deepali Jhamb, Ashutosh Pandey, David F. Tough, Antoon J. M. van Oosterhout, Andrew N. J. McKenzie
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Group 2 innate lymphoid cells (ILC2) increase in frequency in eczema and allergic asthma patients, and thus represent a new therapeutic target cell for type-2 immune-mediated disease. The bromodomain and extra-terminal (BET) protein family of epigene
Externí odkaz:
https://doaj.org/article/cf45591004b94bc9b5c1e9eac52d646f
Autor:
Noe Rodriguez-Rodriguez, Paula A. Clark, Mayuri Gogoi, Ana C. F. Ferreira, Bernhard Kerscher, Alastair Crisp, Helen E. Jolin, Jane E. Murphy, Meera Sivasubramaniam, Luisa Pedro, Jennifer A. Walker, Morgan W. D. Heycock, Jacqueline D. Shields, Jillian L. Barlow, Andrew N. J. McKenzie
Peer reviewed: True
The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have
The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9abacda08a781806bece8f560aff401
Autor:
Padraic G. Fallon, Betania Mahler-Araujo, Martin Dale, Anne-Claire Guénantin, Guillaume Bidault, Aurelien Dugourd, Marcella Ma, Arthur Kaser, Stefania Carobbio, Jennifer Leggat, Julio Saez-Rodriguez, Helen E. Jolin, Andrew N J McKenzie, Kasparas Petkevicius, Brian Y H Lam, Samuel Virtue, Antonio Vidal-Puig
Publikováno v:
Nature Metabolism. 3:1150-1162
Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation1. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites2, improving insulin se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d369c0919c8e33d03fb561a2b2d7fe26
https://doi.org/10.1038/s42255-021-00440-5
https://doi.org/10.1038/s42255-021-00440-5
Autor:
Mark Wing, Morgan W. D. Heycock, Caroline A. Oedekoven, Jennifer A. Walker, Meera Sivasubramaniam, David G. Kent, Richard Pannell, Mayuri Gogoi, Gareth King, Lesley F Drynan, Noé Rodríguez-Rodríguez, Andrew J. Easton, Andrew N. J. McKenzie, Jillian L. Barlow, Padraic G. Fallon, Helen E. Jolin, Michael R. G. Hodskinson, Batika M. J. Rana, Veera Panova
Publikováno v:
Mucosal Immunology
Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM). However, despite the lack of neutrophil chemoattractants such as CXCL1, neutrophils, a feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6056ae64d6790cc546acf03aa95e39
https://doi.org/10.1038/s41385-020-0298-2
https://doi.org/10.1038/s41385-020-0298-2
Autor:
Susan E. Davies, Rune Busk Damgaard, David Komander, Helen E. Jolin, Andrew N J McKenzie, Michael Allison, Hannah Titheradge
Publikováno v:
Damgaard, R B, Jolin, H E, Allison, M E D, Davies, S E, Titheradge, H L, McKenzie, A N J & Komander, D 2020, ' OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer ', Cell Death and Differentiation, vol. 27, pp. 1457-1474 . https://doi.org/10.1038/s41418-020-0532-1
Cell Death and Differentiation
Cell Death and Differentiation
Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-κB activation, immune homoeostasis, and prevents tumour necrosis factor (TNF)-induced cell death. The deubiquitinase OTULIN ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e192858f14645fd06b7d632d7e73ebdc
https://doi.org/10.1038/s41418-020-0532-1
https://doi.org/10.1038/s41418-020-0532-1
Autor:
Emilie J. Cosway, Andrea J. White, Sonia M. Parnell, Edina Schweighoffer, Helen E. Jolin, Andrea Bacon, Hans-Reimer Rodewald, Victor Tybulewicz, Andrew N. J. McKenzie, William E. Jenkinson, Graham Anderson
Publikováno v:
Science immunology. 7(69)
Therapeutic interventions used for cancer treatment provoke thymus damage and limit the recovery of protective immunity. Here, we show that eosinophils are an essential part of an intrathymic type 2 immune network that enables thymus recovery after a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8297804b6b50ac594eda43d133d9ec0
https://pubmed.ncbi.nlm.nih.gov/35275754
https://pubmed.ncbi.nlm.nih.gov/35275754
Autor:
Eric Jou, Noe Rodriguez-Rodriguez, Ana-Carolina F. Ferreira, Helen E. Jolin, Paula A. Clark, Kovilen Sawmynaden, Michelle Ko, Jane E. Murphy, Jonathan Mannion, Christopher Ward, David J. Matthews, Simon J. A. Buczacki, Andrew N. J. McKenzie
Publikováno v:
Science Immunology
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33–activated ILC2s were previously found to augment protective tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd5ab02a6b517faea2d58da77c6a5e7