Výsledky vyhledávání - "Helen Donners"

Akademický článek

International network for comparison of HIV neutralization assays: the NeutNet report.

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4505 (2009)

Neutralizing antibody assessments play a central role in human immunodeficiency virus type-1 (HIV-1) vaccine development but it is unclear which assay, or combination of assays, will provide reliable measures of correlates of protection. To address t

Externí odkaz: https://doaj.org/article/fac6af32cdf44af3997336dd753f82d2

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The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection

Autor: Peter Vanlandschoot, Sophia Steyaert, Els Beirnaert, Geert Leroux-Roels, Lieven Verhoye, Katrien Fransen, Helen Donners, Guido Vanham, Leo Heyndrickx

Publikováno v: Journal of immunological methods
Journal of Immunological Methods

The intrasplenic injection of human peripheral blood mononuclear cells (PBMCs) into severely immune deficient NOD/SCID mice, causes a massive and transient dominant expansion of human B cells in the spleen. This permits the easy isolation of human mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dd1f48548b5e09ebf850449aa64bf7
https://doi.org/10.1016/j.jim.2006.12.003

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The first generation of candidate HIV-1 vaccines can induce antibodies able to neutralize primary isolates in assays with extended incubation phases

Autor: Tine Vermoesen, B. Willems, Guido van der Groen, David Davis, Helen Donners

Publikováno v: Vaccine. 22:104-111

Quantification of human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies is considered to be an important parameter in evaluating candidate vaccines. Most previous studies have failed to detect vaccine-induced antibodies against primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb27f347067f63038ec21e39dd85e4a
https://doi.org/10.1016/s0264-410x(03)00530-9

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International network for comparison of HIV neutralization assays: the NeutNet report II

Publikováno v: PLoS ONE
PLoS ONE; 7(5) (2012)
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS ONE, Vol 7, Iss 5, p e36438 (2012)
PLoS ONE; Vol 7
PLoS ONE, 7(5). Public Library of Science

BACKGROUND: Neutralizing antibodies provide markers for vaccine-induced protective immunity in many viral infections. By analogy, HIV-1 neutralizing antibodies induced by immunization may well predict vaccine effectiveness. Assessment of neutralizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc97e4b0b814d52019898d662ae73c9a
https://hdl.handle.net/20.500.12105/6808

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Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected Donors▿

Autor: Julie M. Decker, Fang-Hua Lee, Amandeep K. Dhillon, Welkin E. Johnson, Robert W. Doms, T. Helen Donners, Douglas D. Richman, Guido Vanham, Dennis R. Burton, Ralph Pantophlet, George M. Shaw

Publikováno v: Journal of virology

Attempts to elicit broadly neutralizing antibody responses by human immunodeficiency virus type 1 (HIV-1) vaccine antigens have been met with limited success. To better understand the requirements for cross-neutralization of HIV-1, we have characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d564bca8c76a31a8627ac5f8fb019f4
https://europepmc.org/articles/PMC1900098/

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Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients

Autor: Katrien Fransen, Guido Vanham, Leo Heyndrickx, Tine Vermoesen, Helen Donners, Filip Van Wanzeele, Beatrijs Vandergucht, Peter Vanlandschoot, Sophia Steyaert, Lieven Verhoye, Geert Leroux-Roels

Publikováno v: Antiviral research

Although a limited number of HIV-infected patients have broadly neutralizing antibodies, it has not been examined whether these antibodies can protect against infection with primary virus in vivo. Here we screened the plasma of 23 HIV-1-infected pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e00f937df26d93e3d87e29c9bc2ef30
https://hdl.handle.net/10067/689640151162165141

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Neutralization of primary HIV-1 SF13 can be detected in extended incubation phase assays with sera from monkeys immunized with recombinant HIV-1 SF2 gp120

Autor: B. Willems, Guido Vanham, Guido van der Groen, Helen Donners, Susan W. Barnett, Lennart Åkerblom, Karin Lovgren-Bengtsson, Bror Morein, David Davis, Jonathan L. Heeney

Publikováno v: Vaccine

Phase III efficacy trials of recombinant human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins were postponed. In Phase I and II trials these candidate vaccines had failed to induce neutralizing antibodies against virus which had been is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f40a748d881af1ae15eb31a6d8b63a
https://hdl.handle.net/10067/455070151162165141

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Inter-subtype cross-neutralizing antibodies recognize epitopes on cell-associated HIV-1 virions

Autor: B. Willems, David Davis, Helen Donners, Guido van der Groen

Publikováno v: Journal of medical virology. 69(2)

HIV-1 infected individuals with cross-neutralizing antibodies against primary HIV-1 isolates belonging to Group M (envA-H) and O, are identified. To investigate the neutralization-kinetics of primary isolates with these antibodies, different neutrali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1879defd9480a550672947f13d1e71
https://pubmed.ncbi.nlm.nih.gov/12683404

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Epitopes corresponding to the envelope genetic subtype are present on the surface of free virions of HIV-1 group M primary isolates and can be detected in neutralization assays with extended incubation phases

Autor: Guido van der Groen, Helen Donners, Leo Heyndrickx, David Davis, Robert Colebunders, Tine Vermoesen, B. Willems

Publikováno v: Journal of medical virology

The hypothesis is that there are neutralizing epitopes on the surface of free virions of human immunodeficiency virus type 1 (HIV-1) that correspond to the genetic subtype of the envelope glycoprotein. Assays with extended incubation and reduced abso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c635c5bc603fc029b79a83a40b682e7f
https://hdl.handle.net/10067/431960151162165141

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Cross-neutralizing antibodies against primary isolates in African women infected with HIV-1

Autor: Helen Donners, Robert Colebunders, Guido van der Groen, David Davis, B. Willems, Els Beirnaert

Publikováno v: AIDS

Our results show that there is a difference in neutralization patterns between African and European plasma especially in African women. An attempt to generate human monoclonal antibodies from African women with broad cross-neutralizing capacity is on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c83a96df56b1e1b09775c62ddf77a0b
https://hdl.handle.net/10067/368330151162165141

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