Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Helen Creedon"'
Autor:
Robert L. Hollis, John P. Thomson, Juliette van Baal, Narthana Ilenkovan, Michael Churchman, Koen van de Vijver, Frederike Dijk, Alison M. Meynert, Clare Bartos, Tzyvia Rye, Ian Croy, Patricia Diana, Mignon van Gent, Helen Creedon, Rachel Nirsimloo, Christianne Lok, Charlie Gourley, C. Simon Herrington
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Low grade serous ovarian carcinoma (LGSOC) demonstrates unique clinical and molecular features compared to other ovarian cancer types. The relationship between common histological features of LGSOC and molecular events, such as hormone recep
Externí odkaz:
https://doaj.org/article/8acb6378ec15437ba487763df432313d
Autor:
Helen Creedon, Lucy A. Balderstone, Morwenna Muir, Jozef Balla, Laura Gomez-Cuadrado, Natasha Tracey, Joseph Loane, Teresa Klinowska, William J. Muller, Valerie G. Brunton
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 2, Pp 131-140 (2016)
Resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapies presents a major clinical problem. Although preclinical studies have identified a number of possible mechanisms, clinical validation has been difficult. This is most lik
Externí odkaz:
https://doaj.org/article/9bca2b31eade465094c52acd2b44fcc0
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Donald M. Salter, Jayne Culley, Martin Lee, John C. Dawson, Jocelyn Ward, Morwenna Muir, Helen Creedon, Georgia L. Dodd, Jun Li, Hitesh Patel, Sana Sarvi
Figure S3 shows generation of Kindlin-1 deficient Met-1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c800512ee2ce22305e7d69174dcc5
https://doi.org/10.1158/0008-5472.22417580.v1
https://doi.org/10.1158/0008-5472.22417580.v1
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Donald M. Salter, Jayne Culley, Martin Lee, John C. Dawson, Jocelyn Ward, Morwenna Muir, Helen Creedon, Georgia L. Dodd, Jun Li, Hitesh Patel, Sana Sarvi
In breast cancer, increased expression of the cytoskeletal adaptor protein Kindlin-1 has been linked to increased risks of lung metastasis, but the functional basis is unknown. Here, we show that in a mouse model of polyomavirus middle T antigen–in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113c507323ff7a9adeaa4e555a5bc4f9
https://doi.org/10.1158/0008-5472.c.6509879.v1
https://doi.org/10.1158/0008-5472.c.6509879.v1
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Donald M. Salter, Jayne Culley, Martin Lee, John C. Dawson, Jocelyn Ward, Morwenna Muir, Helen Creedon, Georgia L. Dodd, Jun Li, Hitesh Patel, Sana Sarvi
Table S1 provides annotation of the Kindlin-1 dependent secretome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e634c59bce5ebea8845730a6281ca8
https://doi.org/10.1158/0008-5472.22417565
https://doi.org/10.1158/0008-5472.22417565
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Donald M. Salter, Jayne Culley, Martin Lee, John C. Dawson, Jocelyn Ward, Morwenna Muir, Helen Creedon, Georgia L. Dodd, Jun Li, Hitesh Patel, Sana Sarvi
Additional methods for experiments shown in the supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d799c9bf93588089ceb9969667df72e
https://doi.org/10.1158/0008-5472.22417568.v1
https://doi.org/10.1158/0008-5472.22417568.v1
Autor:
John P Thomson, Robert L Hollis, Juliette van Baal, Narthana Ilenkovan, Michael Churchman, Koen van de Vijver, Frederike Dijk, Alison M Meynert, Clare Bartos, Tzyvia Rye, Ian Croy, Patricia Diana, Mignon van Gent, Helen Creedon, Rachel Nirsimloo, Fiona Nussey, Christianne Lok, C. Simon Herrington, Charlie Gourley
BackgroundLow-grade serous ovarian carcinoma (LGSOC) is a distinct, under-investigated and relatively chemotherapy-resistant ovarian cancer type. Understanding the molecular landscape is crucial to maximise the impact of molecularly-targeted therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7f686af19779e08fd30513b492b11d
https://doi.org/10.1101/2022.02.01.22270258
https://doi.org/10.1101/2022.02.01.22270258
Autor:
Helen Creedon, Valerie G. Brunton, Teresa Klinowska, Jayne Culley, Natasha Tracey, Alain J. Kemp, Morwenna Muir
Publikováno v:
Tracey, N, Creedon, H, Kemp, A J, Culley, J, Muir, M, Klinowska, T & Brunton, V 2019, ' HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies ', Breast cancer research and treatment . https://doi.org/10.1007/s10549-019-05489-1
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment
Purpose Targeted therapies have resulted in major advances in the treatment of HER2-positive breast cancers. Despite this, up to 70% of patients will develop resistance to treatment within 2 years and new strategies for targeting resistant disease ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9157763451fa3d16151c43643e3949e2
https://www.pure.ed.ac.uk/ws/files/120283126/Tracey2019_Article_HO_1DrivesAutophagyAsAMechanis.pdf
https://www.pure.ed.ac.uk/ws/files/120283126/Tracey2019_Article_HO_1DrivesAutophagyAsAMechanis.pdf
Autor:
Hitesh Patel, Jun Li, Donald Salter, Martin Lee, Georgia L. Dodd, Morwenna Muir, Valerie G. Brunton, John C. Dawson, Andrew H. Sims, Sana Sarvi, Jocelyn Ward, Jayne Culley, Adam Byron, Helen Creedon
Publikováno v:
Sarvi, S, Patel, H, Li, J, Dodd, G L, Creedon, H, Muir, M, Ward, J, Dawson, J C, Lee, M, Culley, J, Salter, D M, Sims, A H, Byron, A & Brunton, V G 2018, ' Kindlin-1 promotes pulmonary breast cancer metastasis ', Cancer Research, vol. 78, no. 6, pp. 1484-1496 . https://doi.org/10.1158/0008-5472.CAN-17-1518
In breast cancer, increased expression of the cytoskeletal adaptor protein Kindlin-1 has been linked to increased risks of lung metastasis, but the functional basis is unknown. Here, we show that in a mouse model of polyomavirus middle T antigen–in
Publikováno v:
Breast Cancer Research and Treatment