Zobrazeno 1 - 10
of 468
pro vyhledávání: '"Helen Cox"'
Autor:
Chacha Mangu, Marta Cossa, Robert Ndege, Celso Khosa, Vinzeigh Leukes, Laura de la Torre-Pérez, Antonio Machiana, Bernard Kivuma, Dorcas Mnzava, Craysophy Zachariah, Patricia Manjate, Elisa Tagliani, Claudia Schacht, Julia Buech, Sunita Singh, Joanna Ehrlich, Friedrich Riess, Sergi Sanz, Katharina Kranzer, Helen Cox, Issa Sabi, Dinis Nguenha, Bindiya Meggi, Maja Weisser, Nyanda Ntinginya, Samuel Schumacher, Morten Ruhwald, Adam Penn-Nicholson, Alberto L. Garcia-Basteiro, TB-CAPT Consortium
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Introduction Tuberculosis (TB) is an important cause of morbidity and mortality among people living with HIV (PLHIV). Current WHO-recommended strategies for diagnosing TB among hospitalized PLHIV rely on symptom screening and disease severit
Externí odkaz:
https://doaj.org/article/e8ff71986d5249bd86e48add2cf630d4
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Multi-drug or rifamycin-resistant tuberculosis (MDR/RR-TB) is an important public health concern, including in settings with high HIV prevalence. TB drug resistance can be directly transmitted or arise through resistance acquisiti
Externí odkaz:
https://doaj.org/article/8e1cb6f54ca74d67bb8e6543231c6797
Autor:
Lee Tatham, Anja Kipar, Jo Sharp, Edyta Kijak, Joanne Herriott, Megan Neary, Helen Box, Eduardo Gallardo Toledo, Anthony Valentijn, Helen Cox, Henry Pertinez, Paul Curley, Usman Arshad, Rajith Kumar Reddy Rajoli, Steve Rannard, James P. Stewart, Andrew Owen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT With some exceptions, global policymakers have recommended against the use of existing monoclonal antibodies in COVID-19 due to loss of neutralization of newer variants. The purpose of this study was to investigate the impact of Ronapreve on
Externí odkaz:
https://doaj.org/article/f7da676fb57b4ce9b203c40c216624a1
Autor:
Etthel M Windels, Eddie M Wampande, Moses L Joloba, W Henry Boom, Galo A Goig, Helen Cox, Jerry Hella, Sonia Borrell, Sebastien Gagneux, Daniela Brites, Tanja Stadler
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1011675 (2024)
Persons living with HIV are known to be at increased risk of developing tuberculosis (TB) disease upon infection with Mycobacterium tuberculosis (Mtb). However, it has remained unclear how HIV co-infection affects subsequent Mtb transmission from the
Externí odkaz:
https://doaj.org/article/e1114ebdf0ff4fb09f88e313280d9faa
Autor:
Koleka Mlisana, John Black, Alison Grant, Marian Loveday, Karina Kielmann, Mosa Moshabela, Helen Cox, Jeremy Hill, Norbert Ndjeka, Mark Nicol, Waasila Jassat, Sacha Roxanne Le Roux, Lindy Dickson, Leila Mitrani
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Objectives Treatment for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) is increasingly transitioning from hospital-centred to community-based care. A national policy for decentralised programmatic MDR/RR-TB care was adopted in Sou
Externí odkaz:
https://doaj.org/article/7c0368a329e44527ab2ed612db73f620
Autor:
Matthias Merker, Jean-Philippe Rasigade, Maxime Barbier, Helen Cox, Silke Feuerriegel, Thomas A. Kohl, Egor Shitikov, Kadri Klaos, Cyril Gaudin, Rudy Antoine, Roland Diel, Sonia Borrell, Sebastien Gagneux, Vladyslav Nikolayevskyy, Sönke Andres, Valeriu Crudu, Philip Supply, Stefan Niemann, Thierry Wirth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
An outbreak of the multidrug-resistant Mycobacterium tuberculosis lineage W148 has spread widely across Russia, Central Asia and Europe. Here, the authors use whole genome sequences of ~700 isolates of this lineage collected over ~20 years to analyze
Externí odkaz:
https://doaj.org/article/c70c19b7a3c948aeb23e2752cc5b39e1
Autor:
Michaela Zwyer, Liliana K Rutaihwa, Etthel Windels, Jerry Hella, Fabrizio Menardo, Mohamed Sasamalo, Gregor Sommer, Lena Schmülling, Sonia Borrell, Miriam Reinhard, Anna Dötsch, Hellen Hiza, Christoph Stritt, George Sikalengo, Lukas Fenner, Bouke C De Jong, Midori Kato-Maeda, Levan Jugheli, Joel D Ernst, Stefan Niemann, Leila Jeljeli, Marie Ballif, Matthias Egger, Niaina Rakotosamimanana, Dorothy Yeboah-Manu, Prince Asare, Bijaya Malla, Horng Yunn Dou, Nicolas Zetola, Robert J Wilkinson, Helen Cox, E Jane Carter, Joachim Gnokoro, Marcel Yotebieng, Eduardo Gotuzzo, Alash'le Abimiku, Anchalee Avihingsanon, Zhi Ming Xu, Jacques Fellay, Damien Portevin, Klaus Reither, Tanja Stadler, Sebastien Gagneux, Daniela Brites
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1010893 (2023)
In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC p
Externí odkaz:
https://doaj.org/article/ba4d547f4bca4dfbb5d867e96b99308e
Autor:
Eduardo Gallardo-Toledo, Megan Neary, Joanne Sharp, Joanne Herriott, Edyta Kijak, Chloe Bramwell, Paul Curley, Usman Arshad, Henry Pertinez, Rajith K. R. Rajoli, Anthony Valentijn, Helen Cox, Lee Tatham, Anja Kipar, James P. Stewart, Andrew Owen
Publikováno v:
Viruses, Vol 15, Iss 11, p 2161 (2023)
Pibrentasvir (PIB) has been demonstrated to block exonuclease activity of the SARS-CoV-2 polymerase, protecting favipiravir (FVP) and remdesivir (RDV) from post-incorporation excision and eliciting antiviral synergy in vitro. The present study invest
Externí odkaz:
https://doaj.org/article/2abae7604c2149b0bf1d2616a2ba6281
Autor:
Megan Neary, Joanne Sharp, Eduardo Gallardo-Toledo, Joanne Herriott, Edyta Kijak, Chloe Bramwell, Helen Cox, Lee Tatham, Helen Box, Paul Curley, Usman Arshad, Rajith K. R. Rajoli, Henry Pertinez, Anthony Valentijn, Kevin Dhaliwal, Frank Mc Caughan, James Hobson, Steve Rannard, Anja Kipar, James P. Stewart, Andrew Owen
Publikováno v:
Viruses, Vol 15, Iss 8, p 1744 (2023)
The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2 entry in vitr
Externí odkaz:
https://doaj.org/article/24438ca2f944447a88cab0056c860073
Autor:
Elize Pietersen, Kim Anderson, Helen Cox, Keertan Dheda, Aihua Bian, Bryan E Shepherd, Timothy R Sterling, Robin M Warren, Yuri F van der Heijden
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281097 (2023)
BackgroundUpdated World Health Organization (WHO) treatment guidelines prioritize all-oral drug-resistant tuberculosis (DR-TB) regimens. Several poorly tolerated drugs, such as amikacin and para-aminosalicylic acid (PAS), remain treatment options for
Externí odkaz:
https://doaj.org/article/6aec9fada719453c84cab465a0218067