Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Helen Colquhoun"'
Autor:
Jeffrey Wald, Anja Henningsson, Eva Hanze, Ethan Hoffmann, Haihong Li, Helen Colquhoun, Kristina M. Deligiannidis
Publikováno v:
Clinical pharmacokinetics. 61(9)
Women with postpartum depression (PPD) may expose their infants to antidepressants via breast milk. Brexanolone is the only FDA-approved antidepressant specifically indicated for the treatment of PPD. This open-label, phase Ib study of healthy lactat
Autor:
James J. Doherty, George G. Nomikos, Stephen Kanes, Shane Raines, Inder Kaul, Abdul J. Sankoh, Helen Colquhoun, Jeff Wald, Amy Bullock, Ethan Hoffmann
Publikováno v:
Clinical Pharmacokinetics
Background SAGE-217, a novel γ-aminobutyric acid A (GABAA) receptor positive allosteric modulator, was evaluated in phase I, double-blind, placebo-controlled, single ascending dose (SAD) and multiple ascending dose (MAD) studies to assess the safety
Autor:
Stephen Kanes, James J. Doherty, Aatif M. Husain, Ethan Hoffmann, Helen Colquhoun, Henrikas Vaitkevicius, Mark S. Wainwright, Jan Claassen, Shane Raines, Eric Rosenthal
Publikováno v:
Annals of Neurology. 82:342-352
Objective Super-refractory status epilepticus (SRSE) is a life-threatening form of status epilepticus that continues or recurs despite 24 hours or more of anesthetic treatment. We conducted a multicenter, phase 1/2 study in SRSE patients to evaluate
Autor:
Jeffrey Jonas, Kristina M. Deligiannidis, C. Neill Epperson, Ryan Arnold, David R. Rubinow, Amy Schacterle, Steven M. Paul, Helen Colquhoun, Stephen Kanes, H. Gunduz-Bruce, James J. Doherty, Robert Riesenberg, Shane Raines, Ethan Hoffmann, Samantha Meltzer-Brody
Publikováno v:
The Lancet. 390:480-489
Summary Background Post-partum depression is a serious mood disorder in women that might be triggered by peripartum fluctuations in reproductive hormones. This phase 2 study investigated brexanolone (USAN; formerly SAGE-547 injection), an intravenous
Autor:
Stephen J. Kanes, Adi Eldar-Lissai, Helen Colquhoun, Robert Lasser, Handan Gunduz-Bruce, Kristina M. Deligiannidis, Samantha Meltzer-Brody, Abdul J. Sankoh, Nathan Weedin
Publikováno v:
American Journal of Obstetrics and Gynecology. 222:S659-S660
Autor:
Brian Werneburg, K.M. Deligiannidis, Abdul J. Sankoh, Helen Colquhoun, Samantha Meltzer-Brody, Robert Lasser, S. Kanes, H. Gunduz-Bruce, F. Gressier
Publikováno v:
French Journal of Psychiatry. 1:S185-S186
La brexanolone (BRX) et SAGE-217 sont des steroides neuroactifs modulateurs allosteriques positifs du recepteur GABAA, evalues dans des essais randomises, en double aveugle versus placebo (RCT) dans la depression du post-partum (PPD) et le trouble de
Autor:
Abdul J. Sankoh, H Junker, C Zorumski, James J. Doherty, S Meltzer-Brody, Haihong Li, Jeffrey Jonas, Helen Colquhoun, H. Gunduz-Bruce, S. Kanes, D.R. Rubinow
Publikováno v:
Abstracts of the 1st Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP).
Autor:
Samantha Meltzer-Brody, Stephen J. Kanes, Danielle Dray, Helen Colquhoun, Kristina M. Deligiannidis, Handan Gunduz-Bruce
Publikováno v:
Obstetrics & Gynecology. 135:54S
Autor:
Jeffrey Jonas, Amy Schacterle, Stephen Kanes, Helen Colquhoun, Samantha Meltzer-Brody, C. Neill Epperson, David R. Rubinow, Abdul J. Sankoh, Christine Clemson, Robert Riesenberg, Kristina M. Deligiannidis, Haihong Li
Publikováno v:
Lancet (London, England). 392(10152)
Summary Background Post-partum depression is associated with substantial morbidity, and improved pharmacological treatment options are urgently needed. We assessed brexanolone injection (formerly SAGE-547 injection), a positive allosteric modulator o
Autor:
Robert Riesenberg, D.R. Rubinow, A. Schacterle, C.N. Epperson, Samantha Meltzer-Brody, Abdul J. Sankoh, S. Kanes, Haihong Li, Helen Colquhoun, Jeffrey Jonas, C. Clemson, Kristina M. Deligiannidis
Publikováno v:
Obstetric Anesthesia Digest. 39:87-88