Výsledky vyhledávání - "Helen Chin Sinex"

Supplementary Figures 1 - 10 from Combining Hedgehog Signaling Inhibition with Focal Irradiation on Reduction of Pancreatic Cancer Metastasis

Autor: Jingwu Xie, E. Gabriela Chiorean, Harlan E. Shannon, Marc S. Mendonca, Helmut Hanenberg, Helen Chin-Sinex, Xiaoli Zhang, Gloria H. Su, Hailan Liu, Dongsheng Gu

PDF file - 372K, Supplementary Figure 1 (Fig.S1)- Detection of CD24 transcript in AsPC1 cells, Supplementary Figure 2 (Fig.S2) Detection of Hh target genes in orthotopic pancreatic cancer models, Supplementary Figure 3 (Fig.S3) Expression of SHH and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf5c1591b2102ea48c026d3134b63de
https://doi.org/10.1158/1535-7163.22499871

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Data from Combining Hedgehog Signaling Inhibition with Focal Irradiation on Reduction of Pancreatic Cancer Metastasis

Autor: Jingwu Xie, E. Gabriela Chiorean, Harlan E. Shannon, Marc S. Mendonca, Helmut Hanenberg, Helen Chin-Sinex, Xiaoli Zhang, Gloria H. Su, Hailan Liu, Dongsheng Gu

Pancreatic cancer often presents in advanced stages and is unresponsive to conventional treatments. Thus, the need to develop novel treatment strategies for pancreatic cancer has never been greater. Here, we report that combination of focal irradiati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff204e13a9f781050f93f9e5c9037c5c
https://doi.org/10.1158/1535-7163.c.6536292

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Irradiation of

Autor: Danny, Laurent, Abbi E, Smith, Waylan K, Bessler, Marc, Mendonca, Helen, Chin-Sinex, Martina, Descovich, Andrew E, Horvai, D Wade, Clapp, Jean L, Nakamura

Publikováno v: Neuro-oncology Advances

Background Genetically susceptible individuals can develop malignancies after irradiation of normal tissues. In the context of therapeutic irradiation, it is not known whether irradiating benign neoplasms in susceptible individuals promotes neoplasti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62fff86e8578c653df3a95a43194ad53
https://pubmed.ncbi.nlm.nih.gov/34131650

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Irradiation of Nf1 mutant mouse models of spinal plexiform neurofibromas drives pathologic progression and decreases survival

Autor: Jean L. Nakamura, Marc S. Mendonca, D. Wade Clapp, Waylan K. Bessler, Martina Descovich, Andrew E. Horvai, Danny Laurent, Abbi Smith, Helen Chin-Sinex

Publikováno v: Neuro-Oncology Advances. 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76bc46748ae754c448114827a8093d39
https://doi.org/10.1093/noajnl/vdab063

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DMAPT inhibits NF-κB activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo

Autor: Christopher Watson, Nazmul Huda, Melanie E. Alpuche, David Gilley, Jeremy B. Shapiro, Peter A. Crooks, Ronald H. Shapiro, Helen Chin-Sinex, Marc S. Mendonca, Imade E. Imasuen-Williams, William T. Turchan, Neil C. Estabrook, Gabriel Rangel

Publikováno v: Free Radical Biology and Medicine. 112:318-326

Constitutive activation of the pro-survival transcription factor NF-κB has been associated with resistance to both chemotherapy and radiation therapy in many human cancers, including prostate cancer. Our lab and others have demonstrated that the nat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9ed7d208b5adfe4cb05ea3da0a9d20
https://doi.org/10.1016/j.freeradbiomed.2017.08.001

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Inhibition of P65 and PDK2 Increases Cytotoxicity and Radiation Sensitivity of Pancreatic Cancer Cells

Autor: Helen Chin-Sinex, Joshua A. Streveler, Marc S. Mendonca

Publikováno v: Proceedings of IMPRS. 2

Background: Pancreatic ductal adenocarcinoma (PDAC) is currently the 4th leading cause of cancer death in the US because of late detection and resistance to chemotherapy and radiation. This tumor resistance is partially due to high activity of the tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a69a1904c87a4e266754923f2f097978
https://doi.org/10.18060/23589

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Radiation therapy generates platelet-activating factor agonists

Autor: Dan F. Spandau, Kevin P. McMullen, Robert C. Murphy, Helen Chin-Sinex, Joseph R. Dynlacht, Jeffrey B. Travers, Marc S. Mendonca, Kathleen A. Harrison, Gengxin Li, Raymond L. Konger, Jonathan Weyerbacher, Michael Edward Johnston, Joy Garrett, Ravi P. Sahu

Publikováno v: Oncotarget

Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R). As radiation therapy also induces reactive oxygen species, the present studies were design

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dd11c156adff379a2b9c26cf6e1a28
https://doi.org/10.18632/oncotarget.7878

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